Modification Strategies for Ionic Complementary Self-Assembling Peptides: Taking RADA16-I as an Example
Ion-complementary self-assembling peptides have been studied in many fields for their distinct advantages, mainly due to their self-assembly properties. However, their shortcomings, such as insufficient specific activity and poor mechanical properties, also limited their application. For the better...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/23/5221 |
| _version_ | 1797462242294235136 |
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| author | Weiwei Guo Yinping Ma Lei Hu Yujie Feng Yanmiao Liu Xuedong Yi Wenzhi Zhang Fushan Tang |
| author_facet | Weiwei Guo Yinping Ma Lei Hu Yujie Feng Yanmiao Liu Xuedong Yi Wenzhi Zhang Fushan Tang |
| author_sort | Weiwei Guo |
| collection | DOAJ |
| description | Ion-complementary self-assembling peptides have been studied in many fields for their distinct advantages, mainly due to their self-assembly properties. However, their shortcomings, such as insufficient specific activity and poor mechanical properties, also limited their application. For the better and wider application of these promising biomaterials, ion-complementary self-assembling peptides can be modified with their self-assembly properties not being destroyed to the greatest extent. The modification strategies were reviewed by taking RADA16-I as an example. For insufficient specific activity, RADA16-I can be structurally modified with active motifs derived from the active domain of the extracellular matrix or other related active factors. For weak mechanical properties, materials with strong mechanical properties or that can undergo chemical crosslinking were used to mix with RADA16-I to enhance the mechanical properties of RADA16-I. To improve the performance of RADA16-I as drug carriers, appropriate adjustment of the RADA16-I sequence and/or modification of the RADA16-I-related delivery system with polymer materials or specific molecules can be considered to achieve sustained and controlled release of specific drugs or active factors. The modification strategies reviewed in this paper may provide some references for further basic research and clinical application of ion-complementary self-assembling peptides and their derivatives. |
| first_indexed | 2024-03-09T17:34:44Z |
| format | Article |
| id | doaj.art-4d945d3b88564269abe241e810eb7b8d |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T17:34:44Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-4d945d3b88564269abe241e810eb7b8d2023-11-24T12:00:25ZengMDPI AGPolymers2073-43602022-11-011423522110.3390/polym14235221Modification Strategies for Ionic Complementary Self-Assembling Peptides: Taking RADA16-I as an ExampleWeiwei Guo0Yinping Ma1Lei Hu2Yujie Feng3Yanmiao Liu4Xuedong Yi5Wenzhi Zhang6Fushan Tang7Department of Clinical Pharmacy, Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi 563006, ChinaDepartment of Clinical Pharmacy, Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi 563006, ChinaDepartment of Clinical Pharmacy, Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi 563006, ChinaDepartment of Clinical Pharmacy, Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi 563006, ChinaThe Key Laboratory of Clinical Pharmacy of Zuni City, Zunyi Medical University, Zunyi 563006, ChinaDepartment of Pharmacy, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, ChinaDepartment of Pharmacy, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, ChinaDepartment of Clinical Pharmacy, Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi 563006, ChinaIon-complementary self-assembling peptides have been studied in many fields for their distinct advantages, mainly due to their self-assembly properties. However, their shortcomings, such as insufficient specific activity and poor mechanical properties, also limited their application. For the better and wider application of these promising biomaterials, ion-complementary self-assembling peptides can be modified with their self-assembly properties not being destroyed to the greatest extent. The modification strategies were reviewed by taking RADA16-I as an example. For insufficient specific activity, RADA16-I can be structurally modified with active motifs derived from the active domain of the extracellular matrix or other related active factors. For weak mechanical properties, materials with strong mechanical properties or that can undergo chemical crosslinking were used to mix with RADA16-I to enhance the mechanical properties of RADA16-I. To improve the performance of RADA16-I as drug carriers, appropriate adjustment of the RADA16-I sequence and/or modification of the RADA16-I-related delivery system with polymer materials or specific molecules can be considered to achieve sustained and controlled release of specific drugs or active factors. The modification strategies reviewed in this paper may provide some references for further basic research and clinical application of ion-complementary self-assembling peptides and their derivatives.https://www.mdpi.com/2073-4360/14/23/5221hydrogelactive motifs modificationregenerative medicineself-assembling peptide |
| spellingShingle | Weiwei Guo Yinping Ma Lei Hu Yujie Feng Yanmiao Liu Xuedong Yi Wenzhi Zhang Fushan Tang Modification Strategies for Ionic Complementary Self-Assembling Peptides: Taking RADA16-I as an Example Polymers hydrogel active motifs modification regenerative medicine self-assembling peptide |
| title | Modification Strategies for Ionic Complementary Self-Assembling Peptides: Taking RADA16-I as an Example |
| title_full | Modification Strategies for Ionic Complementary Self-Assembling Peptides: Taking RADA16-I as an Example |
| title_fullStr | Modification Strategies for Ionic Complementary Self-Assembling Peptides: Taking RADA16-I as an Example |
| title_full_unstemmed | Modification Strategies for Ionic Complementary Self-Assembling Peptides: Taking RADA16-I as an Example |
| title_short | Modification Strategies for Ionic Complementary Self-Assembling Peptides: Taking RADA16-I as an Example |
| title_sort | modification strategies for ionic complementary self assembling peptides taking rada16 i as an example |
| topic | hydrogel active motifs modification regenerative medicine self-assembling peptide |
| url | https://www.mdpi.com/2073-4360/14/23/5221 |
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