The protective role of ginsenoside Rg3 in heart diseases and mental disorders
Ginsenoside Rg3, a compound derived from Panax ginseng C. A. Mey., is increasingly recognized for its wide range of pharmacological effects. Under the worldwide healthcare challenges posed by heart diseases, Rg3 stands out as a key subject in modern research on Chinese herbal medicine, offering a no...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1327033/full |
| _version_ | 1797294735876947968 |
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| author | Lili Shi Lili Shi Jinlan Luo Jinlan Luo Xiupan Wei Xizhen Xu Xizhen Xu Ling Tu Ling Tu |
| author_facet | Lili Shi Lili Shi Jinlan Luo Jinlan Luo Xiupan Wei Xizhen Xu Xizhen Xu Ling Tu Ling Tu |
| author_sort | Lili Shi |
| collection | DOAJ |
| description | Ginsenoside Rg3, a compound derived from Panax ginseng C. A. Mey., is increasingly recognized for its wide range of pharmacological effects. Under the worldwide healthcare challenges posed by heart diseases, Rg3 stands out as a key subject in modern research on Chinese herbal medicine, offering a novel approach to therapy. Mental illnesses are significant contributors to global disease mortality, and there is a well-established correlation between cardiac and psychiatric conditions. This connection is primarily due to dysfunctions in the sympathetic-adrenomedullary system (SAM), the hypothalamic-pituitary-adrenal axis, inflammation, oxidative stress, and brain-derived neurotrophic factor impairment. This review provides an in-depth analysis of Rg3’s therapeutic benefits and its pharmacological actions in treating cardiac and mental health disorders respectively. Highlighting its potential for the management of these conditions, Rg3 emerges as a promising, multifunctional therapeutic agent. |
| first_indexed | 2024-03-07T21:36:29Z |
| format | Article |
| id | doaj.art-4d96dd74b83e463a9339e3cd58a6ab8e |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-07T21:36:29Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-4d96dd74b83e463a9339e3cd58a6ab8e2024-02-26T13:16:30ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-02-011510.3389/fphar.2024.13270331327033The protective role of ginsenoside Rg3 in heart diseases and mental disordersLili Shi0Lili Shi1Jinlan Luo2Jinlan Luo3Xiupan Wei4Xizhen Xu5Xizhen Xu6Ling Tu7Ling Tu8Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, ChinaDepartment of Geriatric Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, ChinaDepartment of Rehabilitation Medicine, Zhongda Hospital, Southeast University, Nanjing, ChinaHubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, ChinaDivision of Cardiology and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Geriatric Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan, ChinaGinsenoside Rg3, a compound derived from Panax ginseng C. A. Mey., is increasingly recognized for its wide range of pharmacological effects. Under the worldwide healthcare challenges posed by heart diseases, Rg3 stands out as a key subject in modern research on Chinese herbal medicine, offering a novel approach to therapy. Mental illnesses are significant contributors to global disease mortality, and there is a well-established correlation between cardiac and psychiatric conditions. This connection is primarily due to dysfunctions in the sympathetic-adrenomedullary system (SAM), the hypothalamic-pituitary-adrenal axis, inflammation, oxidative stress, and brain-derived neurotrophic factor impairment. This review provides an in-depth analysis of Rg3’s therapeutic benefits and its pharmacological actions in treating cardiac and mental health disorders respectively. Highlighting its potential for the management of these conditions, Rg3 emerges as a promising, multifunctional therapeutic agent.https://www.frontiersin.org/articles/10.3389/fphar.2024.1327033/fullginsenoside Rg3heart diseasesmental disordersheart failuredepression |
| spellingShingle | Lili Shi Lili Shi Jinlan Luo Jinlan Luo Xiupan Wei Xizhen Xu Xizhen Xu Ling Tu Ling Tu The protective role of ginsenoside Rg3 in heart diseases and mental disorders Frontiers in Pharmacology ginsenoside Rg3 heart diseases mental disorders heart failure depression |
| title | The protective role of ginsenoside Rg3 in heart diseases and mental disorders |
| title_full | The protective role of ginsenoside Rg3 in heart diseases and mental disorders |
| title_fullStr | The protective role of ginsenoside Rg3 in heart diseases and mental disorders |
| title_full_unstemmed | The protective role of ginsenoside Rg3 in heart diseases and mental disorders |
| title_short | The protective role of ginsenoside Rg3 in heart diseases and mental disorders |
| title_sort | protective role of ginsenoside rg3 in heart diseases and mental disorders |
| topic | ginsenoside Rg3 heart diseases mental disorders heart failure depression |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1327033/full |
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