Hypouricemia and Urate Transporters
Hypouricemia is recognized as a rare disorder, defined as a serum uric acid level of 2.0 mg/dL or less. Hypouricemia is divided into an overexcretion type and an underproduction type. The former typical disease is xanthinuria, and the latter is renal hypouricemia (RHUC). The frequency of nephrogenic...
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MDPI AG
2022-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/3/652 |
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| author | Naoyuki Otani Motoshi Ouchi Kazuharu Misawa Ichiro Hisatome Naohiko Anzai |
| author_facet | Naoyuki Otani Motoshi Ouchi Kazuharu Misawa Ichiro Hisatome Naohiko Anzai |
| author_sort | Naoyuki Otani |
| collection | DOAJ |
| description | Hypouricemia is recognized as a rare disorder, defined as a serum uric acid level of 2.0 mg/dL or less. Hypouricemia is divided into an overexcretion type and an underproduction type. The former typical disease is xanthinuria, and the latter is renal hypouricemia (RHUC). The frequency of nephrogenic hypouricemia due to a deficiency of URAT1 is high in Japan, accounting for most asymptomatic and persistent cases of hypouricemia. RHUC results in a high risk of exercise-induced acute kidney injury and urolithiasis. It is vital to promote research on RHUC, as this will lead not only to the elucidation of its pathophysiology but also to the development of new treatments for gout and hyperuricemia. |
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| format | Article |
| id | doaj.art-4d9c3ab2b92440e9a2e2371d3884526f |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:04:41Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-4d9c3ab2b92440e9a2e2371d3884526f2023-11-24T00:33:21ZengMDPI AGBiomedicines2227-90592022-03-0110365210.3390/biomedicines10030652Hypouricemia and Urate TransportersNaoyuki Otani0Motoshi Ouchi1Kazuharu Misawa2Ichiro Hisatome3Naohiko Anzai4Department of Clinical Pharmacology and Therapeutics, Faculty of Medicine, Oita University, Yufu 879-5593, Oita, JapanDepartment of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Mibu 321-0293, Tochigi, JapanDepartment of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Kanagawa, JapanYonago Medical Center, National Hospital Organization, Yonago 683-0006, Tottori, JapanDepartment of Pharmacology, Chiba University Graduate School of Medicine, Chiba 260-8670, Chiba, JapanHypouricemia is recognized as a rare disorder, defined as a serum uric acid level of 2.0 mg/dL or less. Hypouricemia is divided into an overexcretion type and an underproduction type. The former typical disease is xanthinuria, and the latter is renal hypouricemia (RHUC). The frequency of nephrogenic hypouricemia due to a deficiency of URAT1 is high in Japan, accounting for most asymptomatic and persistent cases of hypouricemia. RHUC results in a high risk of exercise-induced acute kidney injury and urolithiasis. It is vital to promote research on RHUC, as this will lead not only to the elucidation of its pathophysiology but also to the development of new treatments for gout and hyperuricemia.https://www.mdpi.com/2227-9059/10/3/652hypouricemiarenal hypouricemiaurate transporterURAT1xanthinuria |
| spellingShingle | Naoyuki Otani Motoshi Ouchi Kazuharu Misawa Ichiro Hisatome Naohiko Anzai Hypouricemia and Urate Transporters Biomedicines hypouricemia renal hypouricemia urate transporter URAT1 xanthinuria |
| title | Hypouricemia and Urate Transporters |
| title_full | Hypouricemia and Urate Transporters |
| title_fullStr | Hypouricemia and Urate Transporters |
| title_full_unstemmed | Hypouricemia and Urate Transporters |
| title_short | Hypouricemia and Urate Transporters |
| title_sort | hypouricemia and urate transporters |
| topic | hypouricemia renal hypouricemia urate transporter URAT1 xanthinuria |
| url | https://www.mdpi.com/2227-9059/10/3/652 |
| work_keys_str_mv | AT naoyukiotani hypouricemiaanduratetransporters AT motoshiouchi hypouricemiaanduratetransporters AT kazuharumisawa hypouricemiaanduratetransporters AT ichirohisatome hypouricemiaanduratetransporters AT naohikoanzai hypouricemiaanduratetransporters |