Which Definition of Upper Rectal Cancer Is Optimal in Selecting Stage II or III Rectal Cancer Patients to Avoid Postoperative Adjuvant Radiation?
BackgroundIn most guidelines, upper rectal cancers (URC) are not recommended to take neoadjuvant or adjuvant radiation. However, the definitions of URC vary greatly. Five definitions had been commonly used to define URC: 1) >10 cm from the anal verge by MRI; 2) >12 cm from the anal ver...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.625459/full |
| _version_ | 1818416913006460928 |
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| author | Xian Hua Gao Xian Hua Gao Bai Zhi Zhai Bai Zhi Zhai Juan Li Jean Luc Tshibangu Kabemba Jean Luc Tshibangu Kabemba Hai Feng Gong Hai Feng Gong Chen Guang Bai Ming Lu Liu Shao Ting Zhang Fu Shen Lian Jie Liu Wei Zhang Wei Zhang |
| author_facet | Xian Hua Gao Xian Hua Gao Bai Zhi Zhai Bai Zhi Zhai Juan Li Jean Luc Tshibangu Kabemba Jean Luc Tshibangu Kabemba Hai Feng Gong Hai Feng Gong Chen Guang Bai Ming Lu Liu Shao Ting Zhang Fu Shen Lian Jie Liu Wei Zhang Wei Zhang |
| author_sort | Xian Hua Gao |
| collection | DOAJ |
| description | BackgroundIn most guidelines, upper rectal cancers (URC) are not recommended to take neoadjuvant or adjuvant radiation. However, the definitions of URC vary greatly. Five definitions had been commonly used to define URC: 1) >10 cm from the anal verge by MRI; 2) >12 cm from the anal verge by MRI; 3) >10 cm from the anal verge by colonoscopy; 4) >12 cm from the anal verge by colonoscopy; 5) above the anterior peritoneal reflection (APR). We hypothesized that the fifth definition is optimal to identify patients with rectal cancer to avoid adjuvant radiation.MethodsThe data of stage II/III rectal cancer patients who underwent radical surgery without preoperative chemoradiotherapy were retrospectively reviewed. The height of the APR was measured, and compared with the tumor height measured by digital rectal examination (DRE), MRI and colonoscopy. The five definitions were compared in terms of prediction of local recurrence, survival, and percentages of patients requiring radiation.ResultsA total of 576 patients were included, with the intraoperative location of 222 and 354 tumors being above and straddle/below the APR, respectively. The median distance of the APR from anal verge (height of APR) as measured by MRI was 8.7 (range: 4.5–14.3) cm. The height of APR positively correlated with body height (r=0.862, P<0.001). The accuracy of the MRI in determining the tumor location with respect to the APR was 92.1%. Rectal cancer above the APR had a significantly lower incidence of local recurrence than those straddle/below the APR (P=0.042). For those above the APR, there was no significant difference in local recurrence between the radiation and no-radiation group. Multivariate analyses showed that tumor location regarding APR was an independent risk factor for LRFS. Tumor height as measured by DRE, MRI and colonoscopy were not related with survival outcomes. Fewer rectal cancer patients required adjuvant radiation using the definition by the APR, compared with other four definitions based on a numerical tumor height measured by MRI and colonoscopy.ConclusionsThe definition of URC as rectal tumor above the APR, might be the optimal definition to select patients with stage II/III rectal cancer to avoid postoperative adjuvant radiation. |
| first_indexed | 2024-12-14T11:58:26Z |
| format | Article |
| id | doaj.art-4d9fbc7e0ba64d8f92ffa5316a167ce8 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T11:58:26Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4d9fbc7e0ba64d8f92ffa5316a167ce82022-12-21T23:02:03ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-02-011010.3389/fonc.2020.625459625459Which Definition of Upper Rectal Cancer Is Optimal in Selecting Stage II or III Rectal Cancer Patients to Avoid Postoperative Adjuvant Radiation?Xian Hua Gao0Xian Hua Gao1Bai Zhi Zhai2Bai Zhi Zhai3Juan Li4Jean Luc Tshibangu Kabemba5Jean Luc Tshibangu Kabemba6Hai Feng Gong7Hai Feng Gong8Chen Guang Bai9Ming Lu Liu10Shao Ting Zhang11Fu Shen12Lian Jie Liu13Wei Zhang14Wei Zhang15Department of Colorectal Surgery, Changhai Hospital, Shanghai, ChinaHereditary Colorectal Cancer Center and Genetic Block Center of Familial Cancer, Changhai Hospital, Shanghai, ChinaDepartment of Colorectal Surgery, Changhai Hospital, Shanghai, ChinaDepartment of Colorectal Surgery, The 6th People’s Hospital of Kunshan, Suzhou, ChinaDepartment of Nephrology, Changhai Hospital, Shanghai, ChinaDepartment of Colorectal Surgery, Changhai Hospital, Shanghai, ChinaDepartment of General Surgery, Central Military Hospital, Kinshasa, Democratic Republic of CongoDepartment of Colorectal Surgery, Changhai Hospital, Shanghai, ChinaHereditary Colorectal Cancer Center and Genetic Block Center of Familial Cancer, Changhai Hospital, Shanghai, ChinaDepartment of Pathology, Changhai Hospital, Shanghai, ChinaDepartment of Radiology, Changhai Hospital, Shanghai, ChinaDepartment of Radiology, Changhai Hospital, Shanghai, ChinaDepartment of Radiology, Changhai Hospital, Shanghai, ChinaDepartment of Colorectal Surgery, Changhai Hospital, Shanghai, ChinaDepartment of Colorectal Surgery, Changhai Hospital, Shanghai, ChinaHereditary Colorectal Cancer Center and Genetic Block Center of Familial Cancer, Changhai Hospital, Shanghai, ChinaBackgroundIn most guidelines, upper rectal cancers (URC) are not recommended to take neoadjuvant or adjuvant radiation. However, the definitions of URC vary greatly. Five definitions had been commonly used to define URC: 1) >10 cm from the anal verge by MRI; 2) >12 cm from the anal verge by MRI; 3) >10 cm from the anal verge by colonoscopy; 4) >12 cm from the anal verge by colonoscopy; 5) above the anterior peritoneal reflection (APR). We hypothesized that the fifth definition is optimal to identify patients with rectal cancer to avoid adjuvant radiation.MethodsThe data of stage II/III rectal cancer patients who underwent radical surgery without preoperative chemoradiotherapy were retrospectively reviewed. The height of the APR was measured, and compared with the tumor height measured by digital rectal examination (DRE), MRI and colonoscopy. The five definitions were compared in terms of prediction of local recurrence, survival, and percentages of patients requiring radiation.ResultsA total of 576 patients were included, with the intraoperative location of 222 and 354 tumors being above and straddle/below the APR, respectively. The median distance of the APR from anal verge (height of APR) as measured by MRI was 8.7 (range: 4.5–14.3) cm. The height of APR positively correlated with body height (r=0.862, P<0.001). The accuracy of the MRI in determining the tumor location with respect to the APR was 92.1%. Rectal cancer above the APR had a significantly lower incidence of local recurrence than those straddle/below the APR (P=0.042). For those above the APR, there was no significant difference in local recurrence between the radiation and no-radiation group. Multivariate analyses showed that tumor location regarding APR was an independent risk factor for LRFS. Tumor height as measured by DRE, MRI and colonoscopy were not related with survival outcomes. Fewer rectal cancer patients required adjuvant radiation using the definition by the APR, compared with other four definitions based on a numerical tumor height measured by MRI and colonoscopy.ConclusionsThe definition of URC as rectal tumor above the APR, might be the optimal definition to select patients with stage II/III rectal cancer to avoid postoperative adjuvant radiation.https://www.frontiersin.org/articles/10.3389/fonc.2020.625459/fullupper rectal canceranterior peritoneal reflectionintraoperative findingMRIradiotherapy |
| spellingShingle | Xian Hua Gao Xian Hua Gao Bai Zhi Zhai Bai Zhi Zhai Juan Li Jean Luc Tshibangu Kabemba Jean Luc Tshibangu Kabemba Hai Feng Gong Hai Feng Gong Chen Guang Bai Ming Lu Liu Shao Ting Zhang Fu Shen Lian Jie Liu Wei Zhang Wei Zhang Which Definition of Upper Rectal Cancer Is Optimal in Selecting Stage II or III Rectal Cancer Patients to Avoid Postoperative Adjuvant Radiation? Frontiers in Oncology upper rectal cancer anterior peritoneal reflection intraoperative finding MRI radiotherapy |
| title | Which Definition of Upper Rectal Cancer Is Optimal in Selecting Stage II or III Rectal Cancer Patients to Avoid Postoperative Adjuvant Radiation? |
| title_full | Which Definition of Upper Rectal Cancer Is Optimal in Selecting Stage II or III Rectal Cancer Patients to Avoid Postoperative Adjuvant Radiation? |
| title_fullStr | Which Definition of Upper Rectal Cancer Is Optimal in Selecting Stage II or III Rectal Cancer Patients to Avoid Postoperative Adjuvant Radiation? |
| title_full_unstemmed | Which Definition of Upper Rectal Cancer Is Optimal in Selecting Stage II or III Rectal Cancer Patients to Avoid Postoperative Adjuvant Radiation? |
| title_short | Which Definition of Upper Rectal Cancer Is Optimal in Selecting Stage II or III Rectal Cancer Patients to Avoid Postoperative Adjuvant Radiation? |
| title_sort | which definition of upper rectal cancer is optimal in selecting stage ii or iii rectal cancer patients to avoid postoperative adjuvant radiation |
| topic | upper rectal cancer anterior peritoneal reflection intraoperative finding MRI radiotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.625459/full |
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