| Summary: | Purpose: To assess the present landscape and future research
directions, a bibliometric analysis was performed to identify the characteristics
of the 100 most-cited articles (T100 articles) on CRPC research.
Methods: A list of the T100 articles investigating CRPC was generated
by searching the Web of Science (WoS) Core Collection database. Different
characteristics of the T100 articles, including the countries/territories,
journals, authors, and research areas, were analyzed.
Results: The number of citations of T100 articles published between
1992 and 2017 ranged from 282 to 3594, with an average of 654.9 citations.
According to the topic of the article, “Mechanisms related to tumor progression
or metastasis” ranked first with 41 T100 articles, while immunotherapy ranked
fourth with 7 T100 articles. The T100 articles originated from 31 countries, with
more than half originating from the USA (n = 89). Professor Scher HI published
the most T100 articles as the first author (4) and as the corresponding author
(5), while Pro De Bono JS from the Institute of Cancer Research published 3
articles as the first author and 8 articles as the corresponding author. The
journal Cancer Research published 20 T100 articles with a total of 8946
citations. The number of T100 articles (r = 0.485, P = 0.01) and the
total number of citations (r = 0.626, P < 0.001) were all positively
correlated with the IF of the journal.
Conclusions: This analysis offers a historical perspective on the
progress and attempts to reveal future trends in CRPC research using bibliometric
analysis. This study’s results suggest that immunotherapy and the study of
androgen receptors as well as their signaling axes will possibly be hot topics
and trends in CRPC research.
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