Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents
Porphyrins and analogous macrocycles exhibit interesting photochemical, catalytic, and luminescence properties demonstrating high potential in the treatment of several diseases. Among them can be highlighted the possibility of application in photodynamic therapy and antimicrobial/antiparasitic PDT,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/9/2080 |
| _version_ | 1797569259602182144 |
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| author | Daiana K. Deda Bernardo A. Iglesias Eduardo Alves Koiti Araki Celia R. S. Garcia |
| author_facet | Daiana K. Deda Bernardo A. Iglesias Eduardo Alves Koiti Araki Celia R. S. Garcia |
| author_sort | Daiana K. Deda |
| collection | DOAJ |
| description | Porphyrins and analogous macrocycles exhibit interesting photochemical, catalytic, and luminescence properties demonstrating high potential in the treatment of several diseases. Among them can be highlighted the possibility of application in photodynamic therapy and antimicrobial/antiparasitic PDT, for example, of malaria parasite. However, the low efficiency generally associated with their low solubility in water and bioavailability have precluded biomedical applications. Nanotechnology can provide efficient strategies to enhance bioavailability and incorporate targeted delivery properties to conventional pharmaceuticals, enhancing the effectiveness and reducing the toxicity, thus improving the adhesion to the treatment. In this way, those limitations can be overcome by using two main strategies: (1) Incorporation of hydrophilic substituents into the macrocycle ring while controlling the interaction with biological systems and (2) by including them in nanocarriers and delivery nanosystems. This review will focus on antiparasitic drugs based on porphyrin derivatives developed according to these two strategies, considering their vast and increasing applications befitting the multiple roles of these compounds in nature. |
| first_indexed | 2024-03-10T20:09:22Z |
| format | Article |
| id | doaj.art-4da10cc6f5134766ad4ede73a58e3bf2 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T20:09:22Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4da10cc6f5134766ad4ede73a58e3bf22023-11-19T23:03:51ZengMDPI AGMolecules1420-30492020-04-01259208010.3390/molecules25092080Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic AgentsDaiana K. Deda0Bernardo A. Iglesias1Eduardo Alves2Koiti Araki3Celia R. S. Garcia4Department of Fundamental Chemistry, Institute of Chemistry, University of Sao Paulo, Av. Prof. Lineu Prestes 748, Butanta, Sao Paulo, SP 05508-000, BrazilBioinorganic and Porphyrinoid Materials Laboratory, Department of Chemistry, Federal University of Santa Maria, Av. Roraima 1000, Camobi, Santa Maria, RS 97105-900, BrazilDepartment of Life Science, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UKDepartment of Fundamental Chemistry, Institute of Chemistry, University of Sao Paulo, Av. Prof. Lineu Prestes 748, Butanta, Sao Paulo, SP 05508-000, BrazilDepartment of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 580, Sao Paulo, SP 05508-900, BrazilPorphyrins and analogous macrocycles exhibit interesting photochemical, catalytic, and luminescence properties demonstrating high potential in the treatment of several diseases. Among them can be highlighted the possibility of application in photodynamic therapy and antimicrobial/antiparasitic PDT, for example, of malaria parasite. However, the low efficiency generally associated with their low solubility in water and bioavailability have precluded biomedical applications. Nanotechnology can provide efficient strategies to enhance bioavailability and incorporate targeted delivery properties to conventional pharmaceuticals, enhancing the effectiveness and reducing the toxicity, thus improving the adhesion to the treatment. In this way, those limitations can be overcome by using two main strategies: (1) Incorporation of hydrophilic substituents into the macrocycle ring while controlling the interaction with biological systems and (2) by including them in nanocarriers and delivery nanosystems. This review will focus on antiparasitic drugs based on porphyrin derivatives developed according to these two strategies, considering their vast and increasing applications befitting the multiple roles of these compounds in nature.https://www.mdpi.com/1420-3049/25/9/2080porphyrinsnanoformulationnanocapsulesmicellesmalaria |
| spellingShingle | Daiana K. Deda Bernardo A. Iglesias Eduardo Alves Koiti Araki Celia R. S. Garcia Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents Molecules porphyrins nanoformulation nanocapsules micelles malaria |
| title | Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents |
| title_full | Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents |
| title_fullStr | Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents |
| title_full_unstemmed | Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents |
| title_short | Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents |
| title_sort | porphyrin derivative nanoformulations for therapy and antiparasitic agents |
| topic | porphyrins nanoformulation nanocapsules micelles malaria |
| url | https://www.mdpi.com/1420-3049/25/9/2080 |
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