Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery
Stress-induced mental health disorders are affecting many people around the world. However, effective drug therapy for curing psychiatric diseases does not occur sufficiently. Many neurotransmitters, hormones, and mechanisms are essential in regulating the body's stress response. One of the mos...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1182345/full |
| _version_ | 1797802914382610432 |
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| author | Mahdi Malekpour Mahdi Malekpour Dorsa Shekouh Mohammad Ebrahim Safavinia Shadi Shiralipour Maryam Jalouli Sahar Mortezanejad Negar Azarpira Niloofar Dehdari Ebrahimi |
| author_facet | Mahdi Malekpour Mahdi Malekpour Dorsa Shekouh Mohammad Ebrahim Safavinia Shadi Shiralipour Maryam Jalouli Sahar Mortezanejad Negar Azarpira Niloofar Dehdari Ebrahimi |
| author_sort | Mahdi Malekpour |
| collection | DOAJ |
| description | Stress-induced mental health disorders are affecting many people around the world. However, effective drug therapy for curing psychiatric diseases does not occur sufficiently. Many neurotransmitters, hormones, and mechanisms are essential in regulating the body's stress response. One of the most critical components of the stress response system is the hypothalamus-pituitary-adrenal (HPA) axis. The FKBP prolyl isomerase 51 (FKBP51) protein is one of the main negative regulators of the HPA axis. FKBP51 negatively regulates the cortisol effects (the end product of the HPA axis) by inhibiting the interaction between glucocorticoid receptors (GRs) and cortisol, causing reduced transcription of downstream cortisol molecules. By regulating cortisol effects, the FKBP51 protein can indirectly regulate the sensitivity of the HPA axis to stressors. Previous studies have indicated the influence of FKBP5 gene mutations and epigenetic changes in different psychiatric diseases and drug responses and recommended the FKBP51 protein as a drug target and a biomarker for psychological disorders. In this review, we attempted to discuss the effects of the FKBP5 gene, its mutations on different psychiatric diseases, and drugs affecting the FKBP5 gene. |
| first_indexed | 2024-03-13T05:12:56Z |
| format | Article |
| id | doaj.art-4da40439d4564108b15317b5baa4d214 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-13T05:12:56Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-4da40439d4564108b15317b5baa4d2142023-06-16T04:35:11ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-06-011410.3389/fpsyt.2023.11823451182345Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discoveryMahdi Malekpour0Mahdi Malekpour1Dorsa Shekouh2Mohammad Ebrahim Safavinia3Shadi Shiralipour4Maryam Jalouli5Sahar Mortezanejad6Negar Azarpira7Niloofar Dehdari Ebrahimi8Student Research Committee, Shiraz University of Medical Sciences, Shiraz, IranTransplant Research Center, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranTransplant Research Center, Shiraz University of Medical Sciences, Shiraz, IranTransplant Research Center, Shiraz University of Medical Sciences, Shiraz, IranStress-induced mental health disorders are affecting many people around the world. However, effective drug therapy for curing psychiatric diseases does not occur sufficiently. Many neurotransmitters, hormones, and mechanisms are essential in regulating the body's stress response. One of the most critical components of the stress response system is the hypothalamus-pituitary-adrenal (HPA) axis. The FKBP prolyl isomerase 51 (FKBP51) protein is one of the main negative regulators of the HPA axis. FKBP51 negatively regulates the cortisol effects (the end product of the HPA axis) by inhibiting the interaction between glucocorticoid receptors (GRs) and cortisol, causing reduced transcription of downstream cortisol molecules. By regulating cortisol effects, the FKBP51 protein can indirectly regulate the sensitivity of the HPA axis to stressors. Previous studies have indicated the influence of FKBP5 gene mutations and epigenetic changes in different psychiatric diseases and drug responses and recommended the FKBP51 protein as a drug target and a biomarker for psychological disorders. In this review, we attempted to discuss the effects of the FKBP5 gene, its mutations on different psychiatric diseases, and drugs affecting the FKBP5 gene.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1182345/fullFKBP5psychiatric diseasesstress induced psychiatric disordersFKBP5 geneticdrug discovery |
| spellingShingle | Mahdi Malekpour Mahdi Malekpour Dorsa Shekouh Mohammad Ebrahim Safavinia Shadi Shiralipour Maryam Jalouli Sahar Mortezanejad Negar Azarpira Niloofar Dehdari Ebrahimi Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery Frontiers in Psychiatry FKBP5 psychiatric diseases stress induced psychiatric disorders FKBP5 genetic drug discovery |
| title | Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery |
| title_full | Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery |
| title_fullStr | Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery |
| title_full_unstemmed | Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery |
| title_short | Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery |
| title_sort | role of fkbp5 and its genetic mutations in stress induced psychiatric disorders an opportunity for drug discovery |
| topic | FKBP5 psychiatric diseases stress induced psychiatric disorders FKBP5 genetic drug discovery |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1182345/full |
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