Transdermal Drug Delivery: Determining Permeation Parameters Using Tape Stripping and Numerical Modeling
The function of transdermal drug delivery (TDD) systems is complex due to the multiple layers necessary for controlling the rate of drug release and the interaction with the patient’s skin. In this work, we study a particular aspect of a TDD system, that is, the parameters that describe the drug per...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/9/1880 |
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| author | Fjola Jonsdottir Bergthora S. Snorradottir Skuli Gunnarsson Elina Georgsdottir Sven Sigurdsson |
| author_facet | Fjola Jonsdottir Bergthora S. Snorradottir Skuli Gunnarsson Elina Georgsdottir Sven Sigurdsson |
| author_sort | Fjola Jonsdottir |
| collection | DOAJ |
| description | The function of transdermal drug delivery (TDD) systems is complex due to the multiple layers necessary for controlling the rate of drug release and the interaction with the patient’s skin. In this work, we study a particular aspect of a TDD system, that is, the parameters that describe the drug permeation through the skin layers. Studies of the diffusion of two compounds were carried out and supported by tape stripping and numerical modeling. The experimental studies are carried out for porcine skin in a Franz diffusion cell and tape stripping is used to quantify the concentration of drug in the stratum corneum. A multi-layered numerical model, based on Fickian diffusion, is used to determine the unknown parameters that define the skin’s permeability, such as the partition between layers and the mass transfer coefficients due to the surface barrier. A significant correlation was found between the numerical modeling and experimental results, indicating that the partition and mass transfer effects at the interlayer boundary are accurately represented in the numerical model. We find that numerical modeling is essential to fully describe the diffusion characteristics. |
| first_indexed | 2024-03-09T22:50:13Z |
| format | Article |
| id | doaj.art-4da4be8532584768ae6f74f747b44ae0 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T22:50:13Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-4da4be8532584768ae6f74f747b44ae02023-11-23T18:22:17ZengMDPI AGPharmaceutics1999-49232022-09-01149188010.3390/pharmaceutics14091880Transdermal Drug Delivery: Determining Permeation Parameters Using Tape Stripping and Numerical ModelingFjola Jonsdottir0Bergthora S. Snorradottir1Skuli Gunnarsson2Elina Georgsdottir3Sven Sigurdsson4Faculty of Industrial Engineering, Mechanical Engineering and Computer Science, University of Iceland, 107 Reykjavik, IcelandFaculty of Pharmaceutical Sciences, University of Iceland, 107 Reykjavik, IcelandFaculty of Industrial Engineering, Mechanical Engineering and Computer Science, University of Iceland, 107 Reykjavik, IcelandFaculty of Pharmaceutical Sciences, University of Iceland, 107 Reykjavik, IcelandFaculty of Industrial Engineering, Mechanical Engineering and Computer Science, University of Iceland, 107 Reykjavik, IcelandThe function of transdermal drug delivery (TDD) systems is complex due to the multiple layers necessary for controlling the rate of drug release and the interaction with the patient’s skin. In this work, we study a particular aspect of a TDD system, that is, the parameters that describe the drug permeation through the skin layers. Studies of the diffusion of two compounds were carried out and supported by tape stripping and numerical modeling. The experimental studies are carried out for porcine skin in a Franz diffusion cell and tape stripping is used to quantify the concentration of drug in the stratum corneum. A multi-layered numerical model, based on Fickian diffusion, is used to determine the unknown parameters that define the skin’s permeability, such as the partition between layers and the mass transfer coefficients due to the surface barrier. A significant correlation was found between the numerical modeling and experimental results, indicating that the partition and mass transfer effects at the interlayer boundary are accurately represented in the numerical model. We find that numerical modeling is essential to fully describe the diffusion characteristics.https://www.mdpi.com/1999-4923/14/9/1880transdermaldiffusionnumerical modelpartitionmass transfertape stripping |
| spellingShingle | Fjola Jonsdottir Bergthora S. Snorradottir Skuli Gunnarsson Elina Georgsdottir Sven Sigurdsson Transdermal Drug Delivery: Determining Permeation Parameters Using Tape Stripping and Numerical Modeling Pharmaceutics transdermal diffusion numerical model partition mass transfer tape stripping |
| title | Transdermal Drug Delivery: Determining Permeation Parameters Using Tape Stripping and Numerical Modeling |
| title_full | Transdermal Drug Delivery: Determining Permeation Parameters Using Tape Stripping and Numerical Modeling |
| title_fullStr | Transdermal Drug Delivery: Determining Permeation Parameters Using Tape Stripping and Numerical Modeling |
| title_full_unstemmed | Transdermal Drug Delivery: Determining Permeation Parameters Using Tape Stripping and Numerical Modeling |
| title_short | Transdermal Drug Delivery: Determining Permeation Parameters Using Tape Stripping and Numerical Modeling |
| title_sort | transdermal drug delivery determining permeation parameters using tape stripping and numerical modeling |
| topic | transdermal diffusion numerical model partition mass transfer tape stripping |
| url | https://www.mdpi.com/1999-4923/14/9/1880 |
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