Survival and medical costs of non‐small cell lung cancer patients according to the first‐line treatment: An observational study using the Kyoto City Integrated Database
Abstract Background Lung cancer is the primary cause of cancer mortality and non‐small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases. New drug treatments have been developed since 2010 but there are concerns about the increase in medical costs. This study aimed to compare s...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.14900 |
| _version_ | 1797805883212693504 |
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| author | Tomonari Shimamoto Yukiko Tateyama Daisuke Kobayashi Keiichi Yamamoto Yoshimitsu Takahashi Hiroaki Ueshima Kosuke Sasaki Takeo Nakayama Taku Iwami |
| author_facet | Tomonari Shimamoto Yukiko Tateyama Daisuke Kobayashi Keiichi Yamamoto Yoshimitsu Takahashi Hiroaki Ueshima Kosuke Sasaki Takeo Nakayama Taku Iwami |
| author_sort | Tomonari Shimamoto |
| collection | DOAJ |
| description | Abstract Background Lung cancer is the primary cause of cancer mortality and non‐small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases. New drug treatments have been developed since 2010 but there are concerns about the increase in medical costs. This study aimed to compare survival and medical costs among patients with NSCLC according to their initial treatment to estimate the impact of early NSCLC detection. Methods Patients with primary NSCLC who filed insurance claims between April 2013 and March 2019 were identified using the Kyoto City Integrated Database. Patients were divided into two groups depending on their initial treatment: the resection group and drug or radiation group. The survival and medical costs were calculated. Results A total of 2609 patients with primary NSCLC were identified. Among them, 1035 patients underwent resection. The 5‐year survival was 75% for the resection group while below 25% for the drug or radiation group. At 6 months of survival, the median cumulative total cost was 2409 thousand yen (interquartile range [IQR] 1947–4012 thousand yen) in the resection group and 2951 thousand yen (IQR 1600–4706 thousand yen) in the drug or radiation group. At 4 years of survival, the cumulative median total cost was 5257 thousand yen (IQR 3808–8243 thousand yen) in the resection group and 10 202 thousand yen (IQR 4845–20 450 thousand yen) in the drug or radiation group. Conclusions As a first‐line therapy in newly diagnosed patients with NSCLC, surgical resection is associated with longer survival and lower medical costs than pharmacotherapy or radiotherapy. |
| first_indexed | 2024-03-13T05:58:51Z |
| format | Article |
| id | doaj.art-4da51b3b934644838dfcc8d33817d7a1 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-03-13T05:58:51Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-4da51b3b934644838dfcc8d33817d7a12023-06-13T02:31:19ZengWileyThoracic Cancer1759-77061759-77142023-06-0114171574158010.1111/1759-7714.14900Survival and medical costs of non‐small cell lung cancer patients according to the first‐line treatment: An observational study using the Kyoto City Integrated DatabaseTomonari Shimamoto0Yukiko Tateyama1Daisuke Kobayashi2Keiichi Yamamoto3Yoshimitsu Takahashi4Hiroaki Ueshima5Kosuke Sasaki6Takeo Nakayama7Taku Iwami8Department of Preventive Services Kyoto University School of Public Health Kyoto JapanDepartment of Preventive Services Kyoto University School of Public Health Kyoto JapanAgency for Health, Safety and Environment Kyoto University Kyoto JapanTranslational Research Institute for Medical Innovation Osaka Dental University Osaka JapanDepartment of Health Informatics Kyoto University School of Public Health Kyoto JapanCenter for Innovative Research and Education in Data Science, Institute for Liberal Arts and Sciences Kyoto University Kyoto JapanDepartment of Health Informatics Kyoto University School of Public Health Kyoto JapanDepartment of Health Informatics Kyoto University School of Public Health Kyoto JapanDepartment of Preventive Services Kyoto University School of Public Health Kyoto JapanAbstract Background Lung cancer is the primary cause of cancer mortality and non‐small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases. New drug treatments have been developed since 2010 but there are concerns about the increase in medical costs. This study aimed to compare survival and medical costs among patients with NSCLC according to their initial treatment to estimate the impact of early NSCLC detection. Methods Patients with primary NSCLC who filed insurance claims between April 2013 and March 2019 were identified using the Kyoto City Integrated Database. Patients were divided into two groups depending on their initial treatment: the resection group and drug or radiation group. The survival and medical costs were calculated. Results A total of 2609 patients with primary NSCLC were identified. Among them, 1035 patients underwent resection. The 5‐year survival was 75% for the resection group while below 25% for the drug or radiation group. At 6 months of survival, the median cumulative total cost was 2409 thousand yen (interquartile range [IQR] 1947–4012 thousand yen) in the resection group and 2951 thousand yen (IQR 1600–4706 thousand yen) in the drug or radiation group. At 4 years of survival, the cumulative median total cost was 5257 thousand yen (IQR 3808–8243 thousand yen) in the resection group and 10 202 thousand yen (IQR 4845–20 450 thousand yen) in the drug or radiation group. Conclusions As a first‐line therapy in newly diagnosed patients with NSCLC, surgical resection is associated with longer survival and lower medical costs than pharmacotherapy or radiotherapy.https://doi.org/10.1111/1759-7714.14900administrative datalung cancermedical expensesnon‐small cell |
| spellingShingle | Tomonari Shimamoto Yukiko Tateyama Daisuke Kobayashi Keiichi Yamamoto Yoshimitsu Takahashi Hiroaki Ueshima Kosuke Sasaki Takeo Nakayama Taku Iwami Survival and medical costs of non‐small cell lung cancer patients according to the first‐line treatment: An observational study using the Kyoto City Integrated Database Thoracic Cancer administrative data lung cancer medical expenses non‐small cell |
| title | Survival and medical costs of non‐small cell lung cancer patients according to the first‐line treatment: An observational study using the Kyoto City Integrated Database |
| title_full | Survival and medical costs of non‐small cell lung cancer patients according to the first‐line treatment: An observational study using the Kyoto City Integrated Database |
| title_fullStr | Survival and medical costs of non‐small cell lung cancer patients according to the first‐line treatment: An observational study using the Kyoto City Integrated Database |
| title_full_unstemmed | Survival and medical costs of non‐small cell lung cancer patients according to the first‐line treatment: An observational study using the Kyoto City Integrated Database |
| title_short | Survival and medical costs of non‐small cell lung cancer patients according to the first‐line treatment: An observational study using the Kyoto City Integrated Database |
| title_sort | survival and medical costs of non small cell lung cancer patients according to the first line treatment an observational study using the kyoto city integrated database |
| topic | administrative data lung cancer medical expenses non‐small cell |
| url | https://doi.org/10.1111/1759-7714.14900 |
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