Distinct characteristics of the DNA damage response in mammalian oocytes
Abstract DNA damage is a critical threat that poses significant challenges to all cells. To address this issue, cells have evolved a sophisticated molecular and cellular process known as the DNA damage response (DDR). Among the various cell types, mammalian oocytes, which remain dormant in the ovary...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2024-02-01
|
| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-024-01178-2 |
| _version_ | 1797275749702434816 |
|---|---|
| author | Jiyeon Leem Crystal Lee Da Yi Choi Jeong Su Oh |
| author_facet | Jiyeon Leem Crystal Lee Da Yi Choi Jeong Su Oh |
| author_sort | Jiyeon Leem |
| collection | DOAJ |
| description | Abstract DNA damage is a critical threat that poses significant challenges to all cells. To address this issue, cells have evolved a sophisticated molecular and cellular process known as the DNA damage response (DDR). Among the various cell types, mammalian oocytes, which remain dormant in the ovary for extended periods, are particularly susceptible to DNA damage. The occurrence of DNA damage in oocytes can result in genetic abnormalities, potentially leading to infertility, birth defects, and even abortion. Therefore, understanding how oocytes detect and repair DNA damage is of paramount importance in maintaining oocyte quality and preserving fertility. Although the fundamental concept of the DDR is conserved across various cell types, an emerging body of evidence reveals striking distinctions in the DDR between mammalian oocytes and somatic cells. In this review, we highlight the distinctive characteristics of the DDR in oocytes and discuss the clinical implications of DNA damage in oocytes. |
| first_indexed | 2024-03-07T15:17:57Z |
| format | Article |
| id | doaj.art-4da5548b101748c3897732840ca5c6e1 |
| institution | Directory Open Access Journal |
| issn | 2092-6413 |
| language | English |
| last_indexed | 2024-03-07T15:17:57Z |
| publishDate | 2024-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-4da5548b101748c3897732840ca5c6e12024-03-05T17:48:06ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132024-02-0156231932810.1038/s12276-024-01178-2Distinct characteristics of the DNA damage response in mammalian oocytesJiyeon Leem0Crystal Lee1Da Yi Choi2Jeong Su Oh3Department of Integrative Biotechnology, Sungkyunkwan UniversityDepartment of Integrative Biotechnology, Sungkyunkwan UniversityDepartment of Integrative Biotechnology, Sungkyunkwan UniversityDepartment of Integrative Biotechnology, Sungkyunkwan UniversityAbstract DNA damage is a critical threat that poses significant challenges to all cells. To address this issue, cells have evolved a sophisticated molecular and cellular process known as the DNA damage response (DDR). Among the various cell types, mammalian oocytes, which remain dormant in the ovary for extended periods, are particularly susceptible to DNA damage. The occurrence of DNA damage in oocytes can result in genetic abnormalities, potentially leading to infertility, birth defects, and even abortion. Therefore, understanding how oocytes detect and repair DNA damage is of paramount importance in maintaining oocyte quality and preserving fertility. Although the fundamental concept of the DDR is conserved across various cell types, an emerging body of evidence reveals striking distinctions in the DDR between mammalian oocytes and somatic cells. In this review, we highlight the distinctive characteristics of the DDR in oocytes and discuss the clinical implications of DNA damage in oocytes.https://doi.org/10.1038/s12276-024-01178-2 |
| spellingShingle | Jiyeon Leem Crystal Lee Da Yi Choi Jeong Su Oh Distinct characteristics of the DNA damage response in mammalian oocytes Experimental and Molecular Medicine |
| title | Distinct characteristics of the DNA damage response in mammalian oocytes |
| title_full | Distinct characteristics of the DNA damage response in mammalian oocytes |
| title_fullStr | Distinct characteristics of the DNA damage response in mammalian oocytes |
| title_full_unstemmed | Distinct characteristics of the DNA damage response in mammalian oocytes |
| title_short | Distinct characteristics of the DNA damage response in mammalian oocytes |
| title_sort | distinct characteristics of the dna damage response in mammalian oocytes |
| url | https://doi.org/10.1038/s12276-024-01178-2 |
| work_keys_str_mv | AT jiyeonleem distinctcharacteristicsofthednadamageresponseinmammalianoocytes AT crystallee distinctcharacteristicsofthednadamageresponseinmammalianoocytes AT dayichoi distinctcharacteristicsofthednadamageresponseinmammalianoocytes AT jeongsuoh distinctcharacteristicsofthednadamageresponseinmammalianoocytes |