The roles of HMGB1 related angiogenesis and lymphangiogenesis in oral cancer

Angiogenesis and lymphangiogenesis are the vital factors in tumor progression and metastasis. In this review, we show that high-mobility group box 1 (HMGB1) is responsible for both angiogenesis and lymphangiogenesis in oral squamous cell carcinoma (OSCC). HMGB1 possesses the dual role as a cytokine...

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Bibliographic Details
Main Authors: Hiroki Kuniyasu, Tomonori Sasahira, Ujjal K. Bhawal, Yoshitomo Chihara, Miyako Kurihara, Kazuhiko Yamamoto, Tadaaki Kirita
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-10-01
Series:Oncology Reviews
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Online Access:http://www.oncologyreviews.org/index.php/or/article/view/16