Platelet Rich Plasma in Orthopedic Surgical Medicine.
There is a global interest in optimizing post-surgical tissue repair strategies, leading to better patient outcomes and fewer complications, most ideally with reduced overall cost. In this regard, in recent years, the interest in autologous biological treatments in orthopedic surgery and sports medi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-02-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2020.1869717 |
| _version_ | 1797684130215886848 |
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| author | Peter A. Everts Albert van Erp Alfred DeSimone Dan S. Cohen Ronald D. Gardner |
| author_facet | Peter A. Everts Albert van Erp Alfred DeSimone Dan S. Cohen Ronald D. Gardner |
| author_sort | Peter A. Everts |
| collection | DOAJ |
| description | There is a global interest in optimizing post-surgical tissue repair strategies, leading to better patient outcomes and fewer complications, most ideally with reduced overall cost. In this regard, in recent years, the interest in autologous biological treatments in orthopedic surgery and sports medicine has increased greatly, and the addition of platelet-rich plasma (PRP) to the surgical armamentarium is of particular note. Unfortunately, the number of PRP preparation devices has also grown immensely over the recent decades, raising meaningful concern for the considerable variation in the qualities of currently available PRP preparations. The lack of consensus on the standardization of PRP preparation and of agreement on condition specific PRP formulations is largely responsible for the sometimes contradictory outcomes in the literature. Furthermore, the full potential of PRP technology, the concept of individualized treatment protocols based on bioformulation options, and platelet dosing, angiogenesis, and antimicrobial and painkilling effects of PRP relevant to orthopedic surgery have rarely been addressed. In this review, we will discuss recent developments regarding PRP preparations and potential therapeutic effects. Additionally, we present a synopsis of several published data regarding PRP applications in orthopedic surgery for treating tendon injuries, inducing bone repair, strengthening spinal fusion outcomes, and supporting major joint replacements. |
| first_indexed | 2024-03-12T00:25:03Z |
| format | Article |
| id | doaj.art-4da63f65f89d4dcb9f1f6077ea536281 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:25:03Z |
| publishDate | 2021-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-4da63f65f89d4dcb9f1f6077ea5362812023-09-15T10:38:09ZengTaylor & Francis GroupPlatelets0953-71041369-16352021-02-0132216317410.1080/09537104.2020.18697171869717Platelet Rich Plasma in Orthopedic Surgical Medicine.Peter A. Everts0Albert van Erp1Alfred DeSimone2Dan S. Cohen3Ronald D. Gardner4Gulf Coast BiologicsOrthopedic PartnershipOrthopedic-Sports Medicine CenterMt. Sinai Medical CenterGardner OrthopedicsThere is a global interest in optimizing post-surgical tissue repair strategies, leading to better patient outcomes and fewer complications, most ideally with reduced overall cost. In this regard, in recent years, the interest in autologous biological treatments in orthopedic surgery and sports medicine has increased greatly, and the addition of platelet-rich plasma (PRP) to the surgical armamentarium is of particular note. Unfortunately, the number of PRP preparation devices has also grown immensely over the recent decades, raising meaningful concern for the considerable variation in the qualities of currently available PRP preparations. The lack of consensus on the standardization of PRP preparation and of agreement on condition specific PRP formulations is largely responsible for the sometimes contradictory outcomes in the literature. Furthermore, the full potential of PRP technology, the concept of individualized treatment protocols based on bioformulation options, and platelet dosing, angiogenesis, and antimicrobial and painkilling effects of PRP relevant to orthopedic surgery have rarely been addressed. In this review, we will discuss recent developments regarding PRP preparations and potential therapeutic effects. Additionally, we present a synopsis of several published data regarding PRP applications in orthopedic surgery for treating tendon injuries, inducing bone repair, strengthening spinal fusion outcomes, and supporting major joint replacements.http://dx.doi.org/10.1080/09537104.2020.1869717angiogenesisantimicrobialbioformulationbone repairleukocyte poorleukocyte richoorthopedic surgerypainkillingplatelet doseplatelet-rich plasmaspinal bone-fusiontendon reconstruction |
| spellingShingle | Peter A. Everts Albert van Erp Alfred DeSimone Dan S. Cohen Ronald D. Gardner Platelet Rich Plasma in Orthopedic Surgical Medicine. Platelets angiogenesis antimicrobial bioformulation bone repair leukocyte poor leukocyte rich o orthopedic surgery painkilling platelet dose platelet-rich plasma spinal bone-fusion tendon reconstruction |
| title | Platelet Rich Plasma in Orthopedic Surgical Medicine. |
| title_full | Platelet Rich Plasma in Orthopedic Surgical Medicine. |
| title_fullStr | Platelet Rich Plasma in Orthopedic Surgical Medicine. |
| title_full_unstemmed | Platelet Rich Plasma in Orthopedic Surgical Medicine. |
| title_short | Platelet Rich Plasma in Orthopedic Surgical Medicine. |
| title_sort | platelet rich plasma in orthopedic surgical medicine |
| topic | angiogenesis antimicrobial bioformulation bone repair leukocyte poor leukocyte rich o orthopedic surgery painkilling platelet dose platelet-rich plasma spinal bone-fusion tendon reconstruction |
| url | http://dx.doi.org/10.1080/09537104.2020.1869717 |
| work_keys_str_mv | AT peteraeverts plateletrichplasmainorthopedicsurgicalmedicine AT albertvanerp plateletrichplasmainorthopedicsurgicalmedicine AT alfreddesimone plateletrichplasmainorthopedicsurgicalmedicine AT danscohen plateletrichplasmainorthopedicsurgicalmedicine AT ronalddgardner plateletrichplasmainorthopedicsurgicalmedicine |