ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

Cystic Fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in defective CFTR-mediated chloride and bicarbonate transport, with dysregulation of epithelial sodium channels (ENaC). These changes alter fluid and elec...

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Bibliographic Details
Main Authors: Thomas Scambler, Heledd H Jarosz-Griffiths, Samuel Lara-Reyna, Shelly Pathak, Chi Wong, Jonathan Holbrook, Fabio Martinon, Sinisa Savic, Daniel Peckham, Michael F McDermott
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
inflammasome
cystic fibrosis
sodium transport
potassium transport
autoinflammation
NLRP3
Online Access:https://elifesciences.org/articles/49248

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