NexGen regen? Challenges and opportunities for growth factors and signaling agents in periodontal regeneration at intrabony defects
Regeneration of periodontal tissues that have been destroyed by inflammatory periodontitis involves the initiation of tissue engineering and wound healing of multiple tissues involved in the function of the teeth, including the periodontal ligament, cementum, and alveolar bone. Such regeneration is...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Dental Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fdmed.2023.1239149/full |
| _version_ | 1797663332054859776 |
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| author | Maria L. Geisinger |
| author_facet | Maria L. Geisinger |
| author_sort | Maria L. Geisinger |
| collection | DOAJ |
| description | Regeneration of periodontal tissues that have been destroyed by inflammatory periodontitis involves the initiation of tissue engineering and wound healing of multiple tissues involved in the function of the teeth, including the periodontal ligament, cementum, and alveolar bone. Such regeneration is termed guided tissue regeneration and the unique challenges to reconstruct these tissues involves a complex interplay of cells, signaling molecules, and scaffolds. While traditional guided tissue regeneration treatments have involved cell occlusive membranes, bone replacement graft scaffolds, and endogenous multipotent mesenchymal stem cells, the use of adjunctive materials to enhance healing outcomes has been studied and many such adjunctive factors are in common current clinical use. This report will focus on the current and emerging adjunctive growth factors and signaling molecules that can be used to optimize periodontal regeneration in periodontal intrabony defects, their mechanisms of action, the challenges associated with periodontal regeneration, and future avenues for research. |
| first_indexed | 2024-03-11T19:12:58Z |
| format | Article |
| id | doaj.art-4da7c20eb7584b29bfb35fa68316a134 |
| institution | Directory Open Access Journal |
| issn | 2673-4915 |
| language | English |
| last_indexed | 2024-03-11T19:12:58Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Dental Medicine |
| spelling | doaj.art-4da7c20eb7584b29bfb35fa68316a1342023-10-09T10:01:36ZengFrontiers Media S.A.Frontiers in Dental Medicine2673-49152023-10-01410.3389/fdmed.2023.12391491239149NexGen regen? Challenges and opportunities for growth factors and signaling agents in periodontal regeneration at intrabony defectsMaria L. GeisingerRegeneration of periodontal tissues that have been destroyed by inflammatory periodontitis involves the initiation of tissue engineering and wound healing of multiple tissues involved in the function of the teeth, including the periodontal ligament, cementum, and alveolar bone. Such regeneration is termed guided tissue regeneration and the unique challenges to reconstruct these tissues involves a complex interplay of cells, signaling molecules, and scaffolds. While traditional guided tissue regeneration treatments have involved cell occlusive membranes, bone replacement graft scaffolds, and endogenous multipotent mesenchymal stem cells, the use of adjunctive materials to enhance healing outcomes has been studied and many such adjunctive factors are in common current clinical use. This report will focus on the current and emerging adjunctive growth factors and signaling molecules that can be used to optimize periodontal regeneration in periodontal intrabony defects, their mechanisms of action, the challenges associated with periodontal regeneration, and future avenues for research.https://www.frontiersin.org/articles/10.3389/fdmed.2023.1239149/fullperiodontal regenerationperiodontitiswound healingregenerative medicinegrowth factorssignaling molecules |
| spellingShingle | Maria L. Geisinger NexGen regen? Challenges and opportunities for growth factors and signaling agents in periodontal regeneration at intrabony defects Frontiers in Dental Medicine periodontal regeneration periodontitis wound healing regenerative medicine growth factors signaling molecules |
| title | NexGen regen? Challenges and opportunities for growth factors and signaling agents in periodontal regeneration at intrabony defects |
| title_full | NexGen regen? Challenges and opportunities for growth factors and signaling agents in periodontal regeneration at intrabony defects |
| title_fullStr | NexGen regen? Challenges and opportunities for growth factors and signaling agents in periodontal regeneration at intrabony defects |
| title_full_unstemmed | NexGen regen? Challenges and opportunities for growth factors and signaling agents in periodontal regeneration at intrabony defects |
| title_short | NexGen regen? Challenges and opportunities for growth factors and signaling agents in periodontal regeneration at intrabony defects |
| title_sort | nexgen regen challenges and opportunities for growth factors and signaling agents in periodontal regeneration at intrabony defects |
| topic | periodontal regeneration periodontitis wound healing regenerative medicine growth factors signaling molecules |
| url | https://www.frontiersin.org/articles/10.3389/fdmed.2023.1239149/full |
| work_keys_str_mv | AT marialgeisinger nexgenregenchallengesandopportunitiesforgrowthfactorsandsignalingagentsinperiodontalregenerationatintrabonydefects |