Treatment of Obesity Through Glial Cell-Derived Neurotrophic Factor Lipid Nanoparticle Delivery in Mice

Treatment of Obesity Through Glial Cell-Derived Neurotrophic Factor Lipid Nanoparticle Delivery in Mice

Background and Aims: The overexpression of glial cell-derived neurotrophic factor (GDNF) in the liver and adipose tissues offers strong protection against high-fat diet (HFD)-induced obesity in mice. We hypothesize that sustainably enhancing GDNF expression in the liver may provide a therapeutic eff...

Full description

Bibliographic Details
Main Authors:	Chunhua Yang, Simon Musyoka Mwangi, Arun Balasubramaniam, Ge Li, Olivier Merlin-Zhang, Yunshan Liu, Shanthi Srinivasan
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Series:	Gastro Hep Advances
Subjects:	Fat Gut Microbiota Liver Weight Gain
Online Access:	http://www.sciencedirect.com/science/article/pii/S2772572323001346

Similar Items

Effects of brine- and NaCl- fermented carrots on lipid metabolism and gut microbiota in high-fat diet-fed mice
by: Jichun Zhao, et al.
Published: (2023-06-01)

Asparagus cochinchinensis alleviates disturbances of lipid metabolism and gut microbiota in high-fat diet-induced obesity mice
by: Shiyue Luo, et al.
Published: (2022-10-01)

High-Fat Diets with Differential Fatty Acids Induce Obesity and Perturb Gut Microbiota in Honey Bee
by: Xiaofei Wang, et al.
Published: (2021-01-01)

Research progress of gut microbiota and obesity caused by high-fat diet
by: Shuyi Fan, et al.
Published: (2023-03-01)

Oligofructose improves small intestinal lipid-sensing mechanisms via alterations to the small intestinal microbiota
by: Savanna N. Weninger, et al.
Published: (2023-08-01)

Naringin ameliorates obesity via stimulating adipose thermogenesis and browning, and modulating gut microbiota in diet-induced obese mice
by: Xiaoping Li, et al.
Published: (2024-01-01)

From Gut Microbiota through Low-Grade Inflammation to Obesity: Key Players and Potential Targets
by: Claudia Vetrani, et al.
Published: (2022-05-01)

Theabrownin from Wuniuzao Dark Tea Regulates Hepatic Lipid Metabolism and Gut Microbiota in Mice Fed High-Fat Diet
by: Qianqian Xu, et al.
Published: (2023-11-01)

Pediococcus pentosaceus PR-1 modulates high-fat-died-induced alterations in gut microbiota, inflammation, and lipid metabolism in zebrafish
by: Yue Liu, et al.
Published: (2023-02-01)

Effects of Non-Polar Dietary and Endogenous Lipids on Gut Microbiota Alterations: The Role of Lipidomics
by: Konstantinos Tsiantas, et al.
Published: (2022-04-01)

Tea polyphenols improve lipid deposition via modulation of gut microbiota in rats and Ningxiang pigs
by: Qiye Wang, et al.
Published: (2024-02-01)

Modulation of fat metabolism and gut microbiota by resveratrol on high-fat diet-induced obese mice
by: Campbell CL, et al.
Published: (2019-01-01)

Milk fat globule membrane supplementation to obese rats during pregnancy and lactation promotes neurodevelopment in offspring via modulating gut microbiota
by: Qichen Yuan, et al.
Published: (2022-08-01)

Dihydroquercetin Supplementation Improved Hepatic Lipid Dysmetabolism Mediated by Gut Microbiota in High-Fat Diet (HFD)-Fed Mice
by: Mengyu Wang, et al.
Published: (2022-12-01)

The administration of Enterococcus faecium SF68 counteracts compositional shifts in the gut microbiota of diet-induced obese mice
by: Adelaide Panattoni, et al.
Published: (2022-12-01)

Effects of Bile Acid Modulation by Dietary Fat, Cholecystectomy, and Bile Acid Sequestrant on Energy, Glucose, and Lipid Metabolism and Gut Microbiota in Mice
by: Sunmin Park, et al.
Published: (2022-05-01)

Effect of different doses of Lacticaseibacillus paracasei K56 on body fat and metabolic parameters in adult individuals with obesity: a pilot study
by: Guzailinuer Kadeer, et al.
Published: (2023-03-01)

Comparative transcriptome and gut microbiota analysis of Exopalaemon carinicauda with different growth rates from a full-sib family
by: Chaofan Xing, et al.
Published: (2023-06-01)

Fecal virome transplantation is sufficient to alter fecal microbiota and drive lean and obese body phenotypes in mice
by: Joshua M. Borin, et al.
Published: (2023-12-01)

Amaranth Supplementation Improves Hepatic Lipid Dysmetabolism and Modulates Gut Microbiota in Mice Fed a High-Fat Diet
by: Yongshou Yang, et al.
Published: (2021-06-01)

High-Fat Diet-Induced Decreased Circulating Bile Acids Contribute to Obesity Associated with Gut Microbiota in Mice
by: Haiying Cai, et al.
Published: (2024-02-01)

Differential Response of Ileal and Colonic Microbiota in Rats with High-Fat Diet-Induced Atherosclerosis
by: Lingmiao Wen, et al.
Published: (2022-09-01)

Ursolic acid ameliorates obesity of mice fed with high-fat diet via alteration of gut microbiota and amino acid metabolism
by: Chunfeng Tian, et al.
Published: (2023-07-01)

Brevibacillus laterosporus BL1, a promising probiotic, prevents obesity and modulates gut microbiota in mice fed a high-fat diet
by: Guangying Weng, et al.
Published: (2022-11-01)

Gut Microbiome and Metabolome Profiles Associated with High-Fat Diet in Mice
by: Jae-Kwon Jo, et al.
Published: (2021-07-01)

The Role of Gut Microbiota in High-Fat-Diet-Induced Diabetes: Lessons from Animal Models and Humans
by: Yue Qi, et al.
Published: (2023-02-01)

Exploring the Dynamic Relationship between the Gut Microbiome and Body Composition across the Human Lifespan: A Systematic Review
by: Ifigeneia Komodromou, et al.
Published: (2024-02-01)

Characteristics of gut microbiota in middle-aged and elderly overweight/obese women based on body composition data
by: CHEN Mengting, et al.
Published: (2023-08-01)

Effect of Enteromorpha Polysaccharide on Intestinal Bacteria and Short Chain Fatty Acids in Obese Golden Hamsters
by: Shiying HUANG, et al.
Published: (2023-02-01)

Cold-Brewed Jasmine Tea Attenuates High-Fat Diet-Induced Obesity and Gut Microbial Dysbiosis
by: Ang Li, et al.
Published: (2022-12-01)

Inflammatory Signatures of Maternal Obesity as Risk Factors for Neurodevelopmental Disorders: Role of Maternal Microbiota and Nutritional Intervention Strategies
by: Francesca Cirulli, et al.
Published: (2022-07-01)

Effects of Animal and Vegetable Proteins on Gut Microbiota in Subjects with Overweight or Obesity
by: Claudia Di Rosa, et al.
Published: (2023-06-01)

Polysaccharides from Platycodon grandiflorus attenuates high-fat diet induced obesity in mice through targeting gut microbiota
by: Weixin Ke, et al.
Published: (2023-10-01)

Influence of Foods and Nutrition on the Gut Microbiome and Implications for Intestinal Health
by: Ping Zhang
Published: (2022-08-01)

The beneficial effects of Tartary buckwheat (Fagopyrum tataricum Gaertn.) on diet-induced obesity in mice are related to the modulation of gut microbiota composition
by: Yiming Zhou, et al.
Published: (2023-07-01)

An Infancy-Onset 20-Year Dietary Counselling Intervention and Gut Microbiota Composition in Adulthood
by: Anniina Keskitalo, et al.
Published: (2022-06-01)

Tartary Buckwheat (<i>Fagopyrum tataricum</i>) Ameliorates Lipid Metabolism Disorders and Gut Microbiota Dysbiosis in High-Fat Diet-Fed Mice
by: Ang Li, et al.
Published: (2022-09-01)

Depletion of Gut Microbiota Inhibits Hepatic Lipid Accumulation in High-Fat Diet-Fed Mice
by: Hui Han, et al.
Published: (2022-08-01)

Lipo-nutritional quality of pork: The lipid composition, regulation, and molecular mechanisms of fatty acid deposition
by: Wuzhou Yi, et al.
Published: (2023-06-01)

The Role of Gut Microbiota in Obesity
by: Durma Anna Celina, et al.
Published: (2024-03-01)