Prevalence of rheumatoid arthritis in low– and middle–income countries: A systematic review and analysis
Background: Rheumatoid arthritis (RA) is an autoimmune disorder that affects the small joints of the body. It is one of the leading causes of chronic morbidity in high–income countries, but little is known about the burden of this disease in low– and middle–income countries (LMIC). Methods: Th...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Edinburgh University Global Health Society
2015-06-01
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| Series: | Journal of Global Health |
| Subjects: | |
| Online Access: | http://jogh.org/documents/issue201501/jogh-05-010409.XML |
| _version_ | 1818943736530337792 |
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| author | Igor Rudan Simrita Sidhu Angeliki Papana Shi–Jiao Meng Yu Xin–Wei Wei Wang Ruth M. Campbell–Page Alessandro Rhyll Demaio Harish Nair Devi Sridhar Evropi Theodoratou Ben Dowman Davies Adeloye Azeem Majeed Josip Car Harry Campbell Wei Wang |
| author_facet | Igor Rudan Simrita Sidhu Angeliki Papana Shi–Jiao Meng Yu Xin–Wei Wei Wang Ruth M. Campbell–Page Alessandro Rhyll Demaio Harish Nair Devi Sridhar Evropi Theodoratou Ben Dowman Davies Adeloye Azeem Majeed Josip Car Harry Campbell Wei Wang |
| author_sort | Igor Rudan |
| collection | DOAJ |
| description | Background:
Rheumatoid arthritis (RA) is an autoimmune disorder that affects the small joints of the body. It is one of the leading causes of chronic morbidity in high–income countries, but little is known
about the burden of this disease in low– and middle–income countries (LMIC).
Methods:
The aim of this study was to estimate the prevalence of RA in six of the World Health Organization's (WHO) regions that harbour LMIC by identifying all relevant studies in those regions. To accomplish this aim various bibliographic databases were searched: PubMed, EMBASE, Global Health, LILACS and the Chinese databases CNKI and WanFang. Studies were selected based on pre–defined inclusion criteria, including a definition of RA based on the 1987 revision of the American College of Rheumatology (ACR) definition.
Results:
Meta–estimates of regional RA prevalence rates for countries
of low or middle income were 0.40% (95% CI: 0.23–0.57%) for
Southeast Asian, 0.37% (95% CI: 0.23–0.51%) for Eastern Mediterranean, 0.62% (95% CI: 0.47–0.77%) for European, 1.25% (95% CI: 0.64–1.86%) for American and 0.42% (95% CI: 0.30–0.53%) for Western Pacific regions. A formal meta–analysis could not be performed for the sub–Saharan African region due to limited data. Male prevalence of RA in LMIC was 0.16% (95% CI: 0.11–0.20%) while the prevalence in women reached 0.75% (95% CI: 0.60–0.90%). This difference between males and females was statistically signifcant (P<0.0001). The prevalence of RA did not differ significantly between urban and rural settings (P=0.353). These prevalence estimates represent 2.60 (95% CI: 1.85–3.34%) million male sufferers and 12.21 (95% CI: 9.78–14.67%) million female sufferers in LMIC in the year 2000, and 3.16 (95% CI: 2.25–4.05%) million affected males and 14.87 (95% CI: 11.91–17.86%) million affected females in LMIC in the year 2010.
Conclusion:
Given that majority of the world’s population resides in LMIC, the number of affected people is substantial, with a projection
to increase in the coming years. Therefore, policy makers and health–care providers need to plan to address a significant disease burden both socially and economically. |
| first_indexed | 2024-12-20T07:32:04Z |
| format | Article |
| id | doaj.art-4dabc94cb4834bb79fd7b0191ec9f74f |
| institution | Directory Open Access Journal |
| issn | 2047-2978 2047-2986 |
| language | English |
| last_indexed | 2024-12-20T07:32:04Z |
| publishDate | 2015-06-01 |
| publisher | Edinburgh University Global Health Society |
| record_format | Article |
| series | Journal of Global Health |
| spelling | doaj.art-4dabc94cb4834bb79fd7b0191ec9f74f2022-12-21T19:48:24ZengEdinburgh University Global Health SocietyJournal of Global Health2047-29782047-29862015-06-0151Prevalence of rheumatoid arthritis in low– and middle–income countries: A systematic review and analysisIgor Rudan0Simrita Sidhu1Angeliki Papana 2 Shi–Jiao Meng3 Yu Xin–Wei4Wei Wang 5Ruth M. Campbell–Page6Alessandro Rhyll Demaio7Harish Nair8Devi Sridhar 9Evropi Theodoratou10Ben Dowman11Davies Adeloye 12Azeem Majeed13Josip Car14Harry Campbell15Wei Wang16The University of Edinburgh Medical School, Edinburgh, Scotland, UK The University of Edinburgh Medical School, Edinburgh, Scotland, UK University of Macedonia, Thessaloniki, GreeceSchool of Public Health, Capital Medical University, Beijing, ChinaSchool of Public Health, Capital Medical University, Beijing, ChinaSchool of Public Health, Capital Medical University, Beijing, China; Department of Integrated Early Childhood and Development, Capital Institute of Paediatrics, Beijing, ChinaThe University of Toronto, Toronto, CanadaCopenhagen School of Global Health, University of Copenhagen, Denmark; Harvard Global Equity Initiative, Harvard Medical School, Cambridge, USAThe University of Edinburgh Medical School, Edinburgh, Scotland, UKThe University of Edinburgh Medical School, Edinburgh, Scotland, UKThe University of Edinburgh Medical School, Edinburgh, Scotland, UKThe University of Edinburgh Medical School, Edinburgh, Scotland, UKThe University of Edinburgh Medical School, Edinburgh, Scotland, UKSchool of Public Health, Imperial College London, London, UKSchool of Public Health, Imperial College London, London, UK; Lee Kong Chian School of Medicine, Nanyang Technological University, SingaporeThe University of Edinburgh Medical School, Edinburgh, Scotland, UKSchool of Public Health, Capital Medical University, Beijing, China; Edith Cowan University, Perth, AustraliaBackground: Rheumatoid arthritis (RA) is an autoimmune disorder that affects the small joints of the body. It is one of the leading causes of chronic morbidity in high–income countries, but little is known about the burden of this disease in low– and middle–income countries (LMIC). Methods: The aim of this study was to estimate the prevalence of RA in six of the World Health Organization's (WHO) regions that harbour LMIC by identifying all relevant studies in those regions. To accomplish this aim various bibliographic databases were searched: PubMed, EMBASE, Global Health, LILACS and the Chinese databases CNKI and WanFang. Studies were selected based on pre–defined inclusion criteria, including a definition of RA based on the 1987 revision of the American College of Rheumatology (ACR) definition. Results: Meta–estimates of regional RA prevalence rates for countries of low or middle income were 0.40% (95% CI: 0.23–0.57%) for Southeast Asian, 0.37% (95% CI: 0.23–0.51%) for Eastern Mediterranean, 0.62% (95% CI: 0.47–0.77%) for European, 1.25% (95% CI: 0.64–1.86%) for American and 0.42% (95% CI: 0.30–0.53%) for Western Pacific regions. A formal meta–analysis could not be performed for the sub–Saharan African region due to limited data. Male prevalence of RA in LMIC was 0.16% (95% CI: 0.11–0.20%) while the prevalence in women reached 0.75% (95% CI: 0.60–0.90%). This difference between males and females was statistically signifcant (P<0.0001). The prevalence of RA did not differ significantly between urban and rural settings (P=0.353). These prevalence estimates represent 2.60 (95% CI: 1.85–3.34%) million male sufferers and 12.21 (95% CI: 9.78–14.67%) million female sufferers in LMIC in the year 2000, and 3.16 (95% CI: 2.25–4.05%) million affected males and 14.87 (95% CI: 11.91–17.86%) million affected females in LMIC in the year 2010. Conclusion: Given that majority of the world’s population resides in LMIC, the number of affected people is substantial, with a projection to increase in the coming years. Therefore, policy makers and health–care providers need to plan to address a significant disease burden both socially and economically.http://jogh.org/documents/issue201501/jogh-05-010409.XMLglobal healthrheumatoid arthritislow and middle income countriesLMICsystematic reviewanalysis |
| spellingShingle | Igor Rudan Simrita Sidhu Angeliki Papana Shi–Jiao Meng Yu Xin–Wei Wei Wang Ruth M. Campbell–Page Alessandro Rhyll Demaio Harish Nair Devi Sridhar Evropi Theodoratou Ben Dowman Davies Adeloye Azeem Majeed Josip Car Harry Campbell Wei Wang Prevalence of rheumatoid arthritis in low– and middle–income countries: A systematic review and analysis Journal of Global Health global health rheumatoid arthritis low and middle income countries LMIC systematic review analysis |
| title | Prevalence of rheumatoid arthritis in low– and middle–income countries: A systematic review and analysis |
| title_full | Prevalence of rheumatoid arthritis in low– and middle–income countries: A systematic review and analysis |
| title_fullStr | Prevalence of rheumatoid arthritis in low– and middle–income countries: A systematic review and analysis |
| title_full_unstemmed | Prevalence of rheumatoid arthritis in low– and middle–income countries: A systematic review and analysis |
| title_short | Prevalence of rheumatoid arthritis in low– and middle–income countries: A systematic review and analysis |
| title_sort | prevalence of rheumatoid arthritis in low and middle income countries a systematic review and analysis |
| topic | global health rheumatoid arthritis low and middle income countries LMIC systematic review analysis |
| url | http://jogh.org/documents/issue201501/jogh-05-010409.XML |
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