Peripheral eosinophilia as an indicator of meningitic angiostrongyliasis in exposed individuals
The diagnosis of meningitic angiostrongyliasis (MA) is based on clinical criteria. A lumbar puncture is used as a diagnostic tool, but it is an invasive procedure. The blood eosinophil levels are also assessed and used in the diagnosis of this disease. We enrolled 47 patients with serologically prov...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
2010-11-01
|
| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000700020 |
| _version_ | 1797756701040967680 |
|---|---|
| author | Kittisak Sawanyawisuth Kanlayanee Sawanyawisuth Vichai Senthong Panita Limpawattana Pewpan M Intapan Somsak Tiamkao Suthipun Jitpimolmard Verajit Chotmongkol Elizabeth Barrett-Connor |
| author_facet | Kittisak Sawanyawisuth Kanlayanee Sawanyawisuth Vichai Senthong Panita Limpawattana Pewpan M Intapan Somsak Tiamkao Suthipun Jitpimolmard Verajit Chotmongkol Elizabeth Barrett-Connor |
| author_sort | Kittisak Sawanyawisuth |
| collection | DOAJ |
| description | The diagnosis of meningitic angiostrongyliasis (MA) is based on clinical criteria. A lumbar puncture is used as a diagnostic tool, but it is an invasive procedure. The blood eosinophil levels are also assessed and used in the diagnosis of this disease. We enrolled 47 patients with serologically proven MA and 131 controls with intestinal parasite infections. An absolute eosinophil count model was found to be the best marker for MA. An eosinophil count of more than 798 cells led to sensitivity, specificity, positive predictive and negative predictive values of 76.6%, 80.2%, 58.1% and 90.5%, respectively. These data support the use of testing for high blood eosinophil levels as a diagnostic tool for MA in individuals that are at risk for this disease. |
| first_indexed | 2024-03-12T18:05:18Z |
| format | Article |
| id | doaj.art-4dac1df4e60f47e087b4ace2986334c7 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:05:18Z |
| publishDate | 2010-11-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-4dac1df4e60f47e087b4ace2986334c72023-08-02T09:28:35ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602010-11-01105794294410.1590/S0074-02762010000700020Peripheral eosinophilia as an indicator of meningitic angiostrongyliasis in exposed individualsKittisak SawanyawisuthKanlayanee SawanyawisuthVichai SenthongPanita LimpawattanaPewpan M IntapanSomsak TiamkaoSuthipun JitpimolmardVerajit ChotmongkolElizabeth Barrett-ConnorThe diagnosis of meningitic angiostrongyliasis (MA) is based on clinical criteria. A lumbar puncture is used as a diagnostic tool, but it is an invasive procedure. The blood eosinophil levels are also assessed and used in the diagnosis of this disease. We enrolled 47 patients with serologically proven MA and 131 controls with intestinal parasite infections. An absolute eosinophil count model was found to be the best marker for MA. An eosinophil count of more than 798 cells led to sensitivity, specificity, positive predictive and negative predictive values of 76.6%, 80.2%, 58.1% and 90.5%, respectively. These data support the use of testing for high blood eosinophil levels as a diagnostic tool for MA in individuals that are at risk for this disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000700020eosinophiliadiagnosismeningitisangiostrongyliasisAngiostrongylus cantonensis |
| spellingShingle | Kittisak Sawanyawisuth Kanlayanee Sawanyawisuth Vichai Senthong Panita Limpawattana Pewpan M Intapan Somsak Tiamkao Suthipun Jitpimolmard Verajit Chotmongkol Elizabeth Barrett-Connor Peripheral eosinophilia as an indicator of meningitic angiostrongyliasis in exposed individuals Memorias do Instituto Oswaldo Cruz eosinophilia diagnosis meningitis angiostrongyliasis Angiostrongylus cantonensis |
| title | Peripheral eosinophilia as an indicator of meningitic angiostrongyliasis in exposed individuals |
| title_full | Peripheral eosinophilia as an indicator of meningitic angiostrongyliasis in exposed individuals |
| title_fullStr | Peripheral eosinophilia as an indicator of meningitic angiostrongyliasis in exposed individuals |
| title_full_unstemmed | Peripheral eosinophilia as an indicator of meningitic angiostrongyliasis in exposed individuals |
| title_short | Peripheral eosinophilia as an indicator of meningitic angiostrongyliasis in exposed individuals |
| title_sort | peripheral eosinophilia as an indicator of meningitic angiostrongyliasis in exposed individuals |
| topic | eosinophilia diagnosis meningitis angiostrongyliasis Angiostrongylus cantonensis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000700020 |
| work_keys_str_mv | AT kittisaksawanyawisuth peripheraleosinophiliaasanindicatorofmeningiticangiostrongyliasisinexposedindividuals AT kanlayaneesawanyawisuth peripheraleosinophiliaasanindicatorofmeningiticangiostrongyliasisinexposedindividuals AT vichaisenthong peripheraleosinophiliaasanindicatorofmeningiticangiostrongyliasisinexposedindividuals AT panitalimpawattana peripheraleosinophiliaasanindicatorofmeningiticangiostrongyliasisinexposedindividuals AT pewpanmintapan peripheraleosinophiliaasanindicatorofmeningiticangiostrongyliasisinexposedindividuals AT somsaktiamkao peripheraleosinophiliaasanindicatorofmeningiticangiostrongyliasisinexposedindividuals AT suthipunjitpimolmard peripheraleosinophiliaasanindicatorofmeningiticangiostrongyliasisinexposedindividuals AT verajitchotmongkol peripheraleosinophiliaasanindicatorofmeningiticangiostrongyliasisinexposedindividuals AT elizabethbarrettconnor peripheraleosinophiliaasanindicatorofmeningiticangiostrongyliasisinexposedindividuals |