Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A distinct clinicopathologic entity
Objective: The objective of this study is to retrospectively evaluate follicular variant of papillary thyroid carcinoma (FVPTC) and reclassify encapsulated FVPTC as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) according to the criteria proposed by The Endocrin...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2018-01-01
|
| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=3;spage=380;epage=382;aulast=Fonseca |
| _version_ | 1818241749863104512 |
|---|---|
| author | Daphne Fonseca Srutimala Bhuyan Sudha S Murthy Vishal Rao Chandrasekhara Rao K V. V N. Raju Challa Sundaram |
| author_facet | Daphne Fonseca Srutimala Bhuyan Sudha S Murthy Vishal Rao Chandrasekhara Rao K V. V N. Raju Challa Sundaram |
| author_sort | Daphne Fonseca |
| collection | DOAJ |
| description | Objective: The objective of this study is to retrospectively evaluate follicular variant of papillary thyroid carcinoma (FVPTC) and reclassify encapsulated FVPTC as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) according to the criteria proposed by The Endocrine Pathology Society working group in 2015 to correlate with outcome. Materials and Methods: Retrospective review of case records of all patients diagnosed as carcinoma of thyroid between 2015 and 2016 was done for the histologic subtype. Gross and microscopic features on resected specimens of FVPTC were reviewed and subtyped as invasive and encapsulated based on capsular/vascular invasion; the encapsulated forms were further studied for size, number, follicular architecture, nuclear features, presence of psammoma bodies, stromal fibrosis, necrosis, mitoses, and lymph node status. Results: Out of the 383 patients with thyroid carcinomas in the study period, 349 were PTC which included 106 FVPTC. Thirty-three patients fulfilled the criteria to be labeled as NIFTP. Total thyroidectomy was performed in 8 patients and hemithyroidectomy in 25 patients. Lymph node dissection along with total thyroidectomy was done in 3 and completion thyroidectomy following hemithyroidectomy was done in 9. There were 29 single and 4 multiple lesions with size varying from 0.2 to 7 cm including 5 lesions measuring <1 cm. The involvement was confined to one lobe in 31 and both lobes in 2 specimens. Patients are on follow-up with no recurrence till date. Conclusion: Thyroid carcinomas currently diagnosed as FVPTC should be evaluated for criteria of NIFTP to avoid overtreatment as they have an indolent behavior. |
| first_indexed | 2024-12-12T13:34:17Z |
| format | Article |
| id | doaj.art-4dacddb21c8443e68f5d7fd4a5d5a0be |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-12-12T13:34:17Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-4dacddb21c8443e68f5d7fd4a5d5a0be2022-12-22T00:22:59ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292018-01-0161338038210.4103/IJPM.IJPM_185_17Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A distinct clinicopathologic entityDaphne FonsecaSrutimala BhuyanSudha S MurthyVishal RaoChandrasekhara RaoK V. V N. RajuChalla SundaramObjective: The objective of this study is to retrospectively evaluate follicular variant of papillary thyroid carcinoma (FVPTC) and reclassify encapsulated FVPTC as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) according to the criteria proposed by The Endocrine Pathology Society working group in 2015 to correlate with outcome. Materials and Methods: Retrospective review of case records of all patients diagnosed as carcinoma of thyroid between 2015 and 2016 was done for the histologic subtype. Gross and microscopic features on resected specimens of FVPTC were reviewed and subtyped as invasive and encapsulated based on capsular/vascular invasion; the encapsulated forms were further studied for size, number, follicular architecture, nuclear features, presence of psammoma bodies, stromal fibrosis, necrosis, mitoses, and lymph node status. Results: Out of the 383 patients with thyroid carcinomas in the study period, 349 were PTC which included 106 FVPTC. Thirty-three patients fulfilled the criteria to be labeled as NIFTP. Total thyroidectomy was performed in 8 patients and hemithyroidectomy in 25 patients. Lymph node dissection along with total thyroidectomy was done in 3 and completion thyroidectomy following hemithyroidectomy was done in 9. There were 29 single and 4 multiple lesions with size varying from 0.2 to 7 cm including 5 lesions measuring <1 cm. The involvement was confined to one lobe in 31 and both lobes in 2 specimens. Patients are on follow-up with no recurrence till date. Conclusion: Thyroid carcinomas currently diagnosed as FVPTC should be evaluated for criteria of NIFTP to avoid overtreatment as they have an indolent behavior.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=3;spage=380;epage=382;aulast=FonsecaEncapsulated follicular variant of papillary thyroid carcinomaindolent behaviornoninvasive follicular thyroid tumor with papillary-like nuclear featuresrevised nomenclature |
| spellingShingle | Daphne Fonseca Srutimala Bhuyan Sudha S Murthy Vishal Rao Chandrasekhara Rao K V. V N. Raju Challa Sundaram Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A distinct clinicopathologic entity Indian Journal of Pathology and Microbiology Encapsulated follicular variant of papillary thyroid carcinoma indolent behavior noninvasive follicular thyroid tumor with papillary-like nuclear features revised nomenclature |
| title | Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A distinct clinicopathologic entity |
| title_full | Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A distinct clinicopathologic entity |
| title_fullStr | Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A distinct clinicopathologic entity |
| title_full_unstemmed | Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A distinct clinicopathologic entity |
| title_short | Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: A distinct clinicopathologic entity |
| title_sort | noninvasive follicular thyroid neoplasm with papillary like nuclear features a distinct clinicopathologic entity |
| topic | Encapsulated follicular variant of papillary thyroid carcinoma indolent behavior noninvasive follicular thyroid tumor with papillary-like nuclear features revised nomenclature |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=3;spage=380;epage=382;aulast=Fonseca |
| work_keys_str_mv | AT daphnefonseca noninvasivefollicularthyroidneoplasmwithpapillarylikenuclearfeaturesadistinctclinicopathologicentity AT srutimalabhuyan noninvasivefollicularthyroidneoplasmwithpapillarylikenuclearfeaturesadistinctclinicopathologicentity AT sudhasmurthy noninvasivefollicularthyroidneoplasmwithpapillarylikenuclearfeaturesadistinctclinicopathologicentity AT vishalrao noninvasivefollicularthyroidneoplasmwithpapillarylikenuclearfeaturesadistinctclinicopathologicentity AT chandrasekhararao noninvasivefollicularthyroidneoplasmwithpapillarylikenuclearfeaturesadistinctclinicopathologicentity AT kvvnraju noninvasivefollicularthyroidneoplasmwithpapillarylikenuclearfeaturesadistinctclinicopathologicentity AT challasundaram noninvasivefollicularthyroidneoplasmwithpapillarylikenuclearfeaturesadistinctclinicopathologicentity |