Immune reconstitution inflammatory syndrome in tuberculous pleurisy and ulcerative colitis: a case report
We present the case of a 46-year-old Caucasian male, affected by ulcerative colitis, who developed tuberculous pleurisy during immunosuppressive therapy; despite proper therapy, worsening of the radiological findings was observed. The case was discussed among an online group of Italian physicians an...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2019-09-01
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| Series: | Monaldi Archives for Chest Disease |
| Subjects: | |
| Online Access: | https://www.monaldi-archives.org/index.php/macd/article/view/1103 |
| _version_ | 1828296483999318016 |
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| author | Federico Piffer Guido Levi Giampietro Marchetti Chiara Barbieri |
| author_facet | Federico Piffer Guido Levi Giampietro Marchetti Chiara Barbieri |
| author_sort | Federico Piffer |
| collection | DOAJ |
| description | We present the case of a 46-year-old Caucasian male, affected by ulcerative colitis, who developed tuberculous pleurisy during immunosuppressive therapy; despite proper therapy, worsening of the radiological findings was observed. The case was discussed among an online group of Italian physicians and diagnosis of immune reconstitution inflammatory syndrome (IRIS) tuberculosis was established. Therapy was continued and full recovery was obtained. IRIS is a syndrome initially described during opportunistic infections in HIV infected after being placed in anti-retroviral therapy. It reveals itself through a wide variety of manifestations, including fever, lymphadenopathies, worsening of lung infiltrates, pleural or pericardial effusion, central nervous system involvement. Few data are available regarding the best therapeutic options. IRIS is an insidious and potentially serious complication of opportunistic infections in immunocompromised patients. The always wider diffusion of immunosuppressive therapies increases the number of patients at risk, therefore physicians need to be aware of the issue. |
| first_indexed | 2024-04-13T12:11:26Z |
| format | Article |
| id | doaj.art-4daef91ba73949cd9f5fe6a493063084 |
| institution | Directory Open Access Journal |
| issn | 1122-0643 2532-5264 |
| language | English |
| last_indexed | 2024-04-13T12:11:26Z |
| publishDate | 2019-09-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj.art-4daef91ba73949cd9f5fe6a4930630842022-12-22T02:47:28ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642019-09-0189310.4081/monaldi.2019.1103Immune reconstitution inflammatory syndrome in tuberculous pleurisy and ulcerative colitis: a case reportFederico Piffer0Guido Levi1Giampietro Marchetti2Chiara Barbieri3Pulmonology Department, APSS Trento, Hospital of ArcoPulmonology Unit, Spedali Civili, BresciaPulmonology Unit, Spedali Civili, BresciaPulmonology Unit, IRCCS Arcispedale Santa Maria Nuova, Reggio EmiliaWe present the case of a 46-year-old Caucasian male, affected by ulcerative colitis, who developed tuberculous pleurisy during immunosuppressive therapy; despite proper therapy, worsening of the radiological findings was observed. The case was discussed among an online group of Italian physicians and diagnosis of immune reconstitution inflammatory syndrome (IRIS) tuberculosis was established. Therapy was continued and full recovery was obtained. IRIS is a syndrome initially described during opportunistic infections in HIV infected after being placed in anti-retroviral therapy. It reveals itself through a wide variety of manifestations, including fever, lymphadenopathies, worsening of lung infiltrates, pleural or pericardial effusion, central nervous system involvement. Few data are available regarding the best therapeutic options. IRIS is an insidious and potentially serious complication of opportunistic infections in immunocompromised patients. The always wider diffusion of immunosuppressive therapies increases the number of patients at risk, therefore physicians need to be aware of the issue.https://www.monaldi-archives.org/index.php/macd/article/view/1103TuberculosisIRISchest ultrasoundthoracoscopyinfliximab |
| spellingShingle | Federico Piffer Guido Levi Giampietro Marchetti Chiara Barbieri Immune reconstitution inflammatory syndrome in tuberculous pleurisy and ulcerative colitis: a case report Monaldi Archives for Chest Disease Tuberculosis IRIS chest ultrasound thoracoscopy infliximab |
| title | Immune reconstitution inflammatory syndrome in tuberculous pleurisy and ulcerative colitis: a case report |
| title_full | Immune reconstitution inflammatory syndrome in tuberculous pleurisy and ulcerative colitis: a case report |
| title_fullStr | Immune reconstitution inflammatory syndrome in tuberculous pleurisy and ulcerative colitis: a case report |
| title_full_unstemmed | Immune reconstitution inflammatory syndrome in tuberculous pleurisy and ulcerative colitis: a case report |
| title_short | Immune reconstitution inflammatory syndrome in tuberculous pleurisy and ulcerative colitis: a case report |
| title_sort | immune reconstitution inflammatory syndrome in tuberculous pleurisy and ulcerative colitis a case report |
| topic | Tuberculosis IRIS chest ultrasound thoracoscopy infliximab |
| url | https://www.monaldi-archives.org/index.php/macd/article/view/1103 |
| work_keys_str_mv | AT federicopiffer immunereconstitutioninflammatorysyndromeintuberculouspleurisyandulcerativecolitisacasereport AT guidolevi immunereconstitutioninflammatorysyndromeintuberculouspleurisyandulcerativecolitisacasereport AT giampietromarchetti immunereconstitutioninflammatorysyndromeintuberculouspleurisyandulcerativecolitisacasereport AT chiarabarbieri immunereconstitutioninflammatorysyndromeintuberculouspleurisyandulcerativecolitisacasereport |