The Regulatory Effect of Phytochemicals on Chronic Diseases by Targeting Nrf2-ARE Signaling Pathway
Redox balance is essential to maintain the body’s normal metabolism. Once disrupted, it may lead to various chronic diseases, such as diabetes, neurodegenerative diseases, cardiovascular diseases, inflammatory diseases, cancer, aging, etc. Oxidative stress can cause or aggravate a series of patholog...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/2/236 |
| _version_ | 1797622697170042880 |
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| author | Wen-Jiang He Cheng-Hao Lv Zhong Chen Meng Shi Chao-Xi Zeng De-Xing Hou Si Qin |
| author_facet | Wen-Jiang He Cheng-Hao Lv Zhong Chen Meng Shi Chao-Xi Zeng De-Xing Hou Si Qin |
| author_sort | Wen-Jiang He |
| collection | DOAJ |
| description | Redox balance is essential to maintain the body’s normal metabolism. Once disrupted, it may lead to various chronic diseases, such as diabetes, neurodegenerative diseases, cardiovascular diseases, inflammatory diseases, cancer, aging, etc. Oxidative stress can cause or aggravate a series of pathological processes. Inhibition of oxidative stress and related pathological processes can help to ameliorate these chronic diseases, which have been found to be associated with Nrf2 activation. Nrf2 activation can not only regulate the expression of a series of antioxidant genes that reduce oxidative stress and its damage, but also directly regulate genes related to the above-mentioned pathological processes to counter the corresponding changes. Therefore, targeting Nrf2 has great potential for the prevention or treatment of chronic diseases, and many natural phytochemicals have been reported as Nrf2 activators although the defined mechanisms remain to be elucidated. This review article focuses on the possible mechanism of Nrf2 activation by natural phytochemicals in the prevention or treatment of chronic diseases and the regulation of oxidative stress. Moreover, the current clinical trials of phytochemical-originated drug discovery by targeting the Nrf2-ARE pathway were also summarized; the outcomes or the relationship between phytochemicals and chronic diseases prevention are finally analyzed to propose the future research strategies and prospective. |
| first_indexed | 2024-03-11T09:14:56Z |
| format | Article |
| id | doaj.art-4db1c555253e4724b6b95b25767f6b96 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T09:14:56Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-4db1c555253e4724b6b95b25767f6b962023-11-16T18:45:17ZengMDPI AGAntioxidants2076-39212023-01-0112223610.3390/antiox12020236The Regulatory Effect of Phytochemicals on Chronic Diseases by Targeting Nrf2-ARE Signaling PathwayWen-Jiang He0Cheng-Hao Lv1Zhong Chen2Meng Shi3Chao-Xi Zeng4De-Xing Hou5Si Qin6College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaCollege of Biological Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaCollege of Food Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaThe United Graduate School of Agricultural Sciences, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, JapanCollege of Food Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaRedox balance is essential to maintain the body’s normal metabolism. Once disrupted, it may lead to various chronic diseases, such as diabetes, neurodegenerative diseases, cardiovascular diseases, inflammatory diseases, cancer, aging, etc. Oxidative stress can cause or aggravate a series of pathological processes. Inhibition of oxidative stress and related pathological processes can help to ameliorate these chronic diseases, which have been found to be associated with Nrf2 activation. Nrf2 activation can not only regulate the expression of a series of antioxidant genes that reduce oxidative stress and its damage, but also directly regulate genes related to the above-mentioned pathological processes to counter the corresponding changes. Therefore, targeting Nrf2 has great potential for the prevention or treatment of chronic diseases, and many natural phytochemicals have been reported as Nrf2 activators although the defined mechanisms remain to be elucidated. This review article focuses on the possible mechanism of Nrf2 activation by natural phytochemicals in the prevention or treatment of chronic diseases and the regulation of oxidative stress. Moreover, the current clinical trials of phytochemical-originated drug discovery by targeting the Nrf2-ARE pathway were also summarized; the outcomes or the relationship between phytochemicals and chronic diseases prevention are finally analyzed to propose the future research strategies and prospective.https://www.mdpi.com/2076-3921/12/2/236phytochemicalschronic diseaseNrf2-ARE pathwaychemoprevention |
| spellingShingle | Wen-Jiang He Cheng-Hao Lv Zhong Chen Meng Shi Chao-Xi Zeng De-Xing Hou Si Qin The Regulatory Effect of Phytochemicals on Chronic Diseases by Targeting Nrf2-ARE Signaling Pathway Antioxidants phytochemicals chronic disease Nrf2-ARE pathway chemoprevention |
| title | The Regulatory Effect of Phytochemicals on Chronic Diseases by Targeting Nrf2-ARE Signaling Pathway |
| title_full | The Regulatory Effect of Phytochemicals on Chronic Diseases by Targeting Nrf2-ARE Signaling Pathway |
| title_fullStr | The Regulatory Effect of Phytochemicals on Chronic Diseases by Targeting Nrf2-ARE Signaling Pathway |
| title_full_unstemmed | The Regulatory Effect of Phytochemicals on Chronic Diseases by Targeting Nrf2-ARE Signaling Pathway |
| title_short | The Regulatory Effect of Phytochemicals on Chronic Diseases by Targeting Nrf2-ARE Signaling Pathway |
| title_sort | regulatory effect of phytochemicals on chronic diseases by targeting nrf2 are signaling pathway |
| topic | phytochemicals chronic disease Nrf2-ARE pathway chemoprevention |
| url | https://www.mdpi.com/2076-3921/12/2/236 |
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