The D-SPECT SH reconstruction protocol: improved quantification of small left ventricle volumes
Abstract Background Due to spatial resolution limitations, conventional NaI-SPECT typically overestimates the left ventricular (LV) ejection fraction (EF) in patients with small LV volumes. The purpose of this study was to explore the clinical application value of the small heart (SH) reconstruction...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-01-01
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| Series: | EJNMMI Physics |
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| Online Access: | https://doi.org/10.1186/s40658-023-00606-y |
| _version_ | 1797355499450007552 |
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| author | Yan Huang Han Zhang Xueping Hu Shanshan Qin Fan Hu Yuchen Li Haidong Cai Kuangyu Shi Fei Yu |
| author_facet | Yan Huang Han Zhang Xueping Hu Shanshan Qin Fan Hu Yuchen Li Haidong Cai Kuangyu Shi Fei Yu |
| author_sort | Yan Huang |
| collection | DOAJ |
| description | Abstract Background Due to spatial resolution limitations, conventional NaI-SPECT typically overestimates the left ventricular (LV) ejection fraction (EF) in patients with small LV volumes. The purpose of this study was to explore the clinical application value of the small heart (SH) reconstruction protocol embedded in the postprocessing procedure of D-SPECT. Methods We retrospectively analyzed patients who undergo both D-SPECT and echocardiography (Echo) within one week. Patients with small LV volume were defined as those with a rest end-systolic volume (rESV) ≤ 25 mL and underwent reconstruction using the standard (SD) reconstruction protocol. The SH protocol was deemed successful in correcting the LVEF value if it decreased by 5% or more compared to the SD protocol. The ROC curve was used to calculate the optimal cutoff value of the SH protocol. LVEF, ESV and EDV were computed with SD and SH, respectively. Echo was performed as a reference, and Echo-LVEF, ESV, and EDV were calculated using the Teichholz formula. One-way ANOVA was used to compare these parameters among the three groups. Results The final study included 209 patients (73.21% female, age 67.34 ± 7.85 years). Compared with the SD protocol, the SH protocol significantly decreased LVEF (67.43 ± 7.38% vs. 71.30 ± 7.61%, p < 0.001). The optimal cutoff value for using the SH protocol was rESV > 17 mL (AUC = 0.651, sensitivity = 78.43%, specificity = 45.57%, p = 0.001). In the subgroup of rESV > 17 mL, there was no significant difference in LVEF (61.84 ± 4.67% vs. 62.83 ± 2.85%, p = 0.481) between the SH protocol and Echo, and no significant difference was observed in rESV (26.92 ± 3.25 mL vs. 27.94 ± 7.96 mL, p = 0.60) between the SH protocol and Echo. Conclusion This pilot study demonstrated that the SH reconstruction protocol was able to effectively correct the overestimation of LVEF in patients with small LV volumes. Particularly, in the rESV > 17 mL subgroup, the time and computing power waste could be reduced while still ensuring the accuracy of the LVEF value and image quality. |
| first_indexed | 2024-03-08T14:12:02Z |
| format | Article |
| id | doaj.art-4db20349413f42669ed5540abe124c64 |
| institution | Directory Open Access Journal |
| issn | 2197-7364 |
| language | English |
| last_indexed | 2024-03-08T14:12:02Z |
| publishDate | 2024-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Physics |
| spelling | doaj.art-4db20349413f42669ed5540abe124c642024-01-14T12:37:02ZengSpringerOpenEJNMMI Physics2197-73642024-01-0111111210.1186/s40658-023-00606-yThe D-SPECT SH reconstruction protocol: improved quantification of small left ventricle volumesYan Huang0Han Zhang1Xueping Hu2Shanshan Qin3Fan Hu4Yuchen Li5Haidong Cai6Kuangyu Shi7Fei Yu8Medical College, Anhui University of Science and TechnologyDepartment of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Informatics, Technical University of MunichDepartment of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of MedicineAbstract Background Due to spatial resolution limitations, conventional NaI-SPECT typically overestimates the left ventricular (LV) ejection fraction (EF) in patients with small LV volumes. The purpose of this study was to explore the clinical application value of the small heart (SH) reconstruction protocol embedded in the postprocessing procedure of D-SPECT. Methods We retrospectively analyzed patients who undergo both D-SPECT and echocardiography (Echo) within one week. Patients with small LV volume were defined as those with a rest end-systolic volume (rESV) ≤ 25 mL and underwent reconstruction using the standard (SD) reconstruction protocol. The SH protocol was deemed successful in correcting the LVEF value if it decreased by 5% or more compared to the SD protocol. The ROC curve was used to calculate the optimal cutoff value of the SH protocol. LVEF, ESV and EDV were computed with SD and SH, respectively. Echo was performed as a reference, and Echo-LVEF, ESV, and EDV were calculated using the Teichholz formula. One-way ANOVA was used to compare these parameters among the three groups. Results The final study included 209 patients (73.21% female, age 67.34 ± 7.85 years). Compared with the SD protocol, the SH protocol significantly decreased LVEF (67.43 ± 7.38% vs. 71.30 ± 7.61%, p < 0.001). The optimal cutoff value for using the SH protocol was rESV > 17 mL (AUC = 0.651, sensitivity = 78.43%, specificity = 45.57%, p = 0.001). In the subgroup of rESV > 17 mL, there was no significant difference in LVEF (61.84 ± 4.67% vs. 62.83 ± 2.85%, p = 0.481) between the SH protocol and Echo, and no significant difference was observed in rESV (26.92 ± 3.25 mL vs. 27.94 ± 7.96 mL, p = 0.60) between the SH protocol and Echo. Conclusion This pilot study demonstrated that the SH reconstruction protocol was able to effectively correct the overestimation of LVEF in patients with small LV volumes. Particularly, in the rESV > 17 mL subgroup, the time and computing power waste could be reduced while still ensuring the accuracy of the LVEF value and image quality.https://doi.org/10.1186/s40658-023-00606-yGate myocardial perfusion single-photon computed tomographySmall left ventricle volumeReconstruction algorithmLeft ventricle ejection fraction |
| spellingShingle | Yan Huang Han Zhang Xueping Hu Shanshan Qin Fan Hu Yuchen Li Haidong Cai Kuangyu Shi Fei Yu The D-SPECT SH reconstruction protocol: improved quantification of small left ventricle volumes EJNMMI Physics Gate myocardial perfusion single-photon computed tomography Small left ventricle volume Reconstruction algorithm Left ventricle ejection fraction |
| title | The D-SPECT SH reconstruction protocol: improved quantification of small left ventricle volumes |
| title_full | The D-SPECT SH reconstruction protocol: improved quantification of small left ventricle volumes |
| title_fullStr | The D-SPECT SH reconstruction protocol: improved quantification of small left ventricle volumes |
| title_full_unstemmed | The D-SPECT SH reconstruction protocol: improved quantification of small left ventricle volumes |
| title_short | The D-SPECT SH reconstruction protocol: improved quantification of small left ventricle volumes |
| title_sort | d spect sh reconstruction protocol improved quantification of small left ventricle volumes |
| topic | Gate myocardial perfusion single-photon computed tomography Small left ventricle volume Reconstruction algorithm Left ventricle ejection fraction |
| url | https://doi.org/10.1186/s40658-023-00606-y |
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