Understanding recurrent pregnancy loss: recent advances on its etiology, clinical diagnosis, and management
Recurrent pregnancy loss (RPL) has become an important reproductive health issue worldwide. RPL affects about 2%–3% of reproductive-aged women, and makes serious threats to women’s physical and mental health. However, the etiology of approximately 50% of RPL cases remains unknown (unexplained RPL),...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-12-01
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| Series: | Medical Review |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/mr-2022-0030 |
| _version_ | 1797848642612101120 |
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| author | Cao Chunwei Bai Shiyu Zhang Jing Sun Xiaoyue Meng Anming Chen Hui |
| author_facet | Cao Chunwei Bai Shiyu Zhang Jing Sun Xiaoyue Meng Anming Chen Hui |
| author_sort | Cao Chunwei |
| collection | DOAJ |
| description | Recurrent pregnancy loss (RPL) has become an important reproductive health issue worldwide. RPL affects about 2%–3% of reproductive-aged women, and makes serious threats to women’s physical and mental health. However, the etiology of approximately 50% of RPL cases remains unknown (unexplained RPL), which poses a big challenge for clinical management of these patients. RPL has been widely regarded as a complex disease where its etiology has been attributed to numerous factors. Heretofore, various risk factors for RPL have been identified, such as maternal ages, genetic factors, anatomical structural abnormalities, endocrine dysfunction, prethrombotic state, immunological factors, and infection. More importantly, development and applications of next generation sequencing technology have significantly expanded opportunities to discover chromosomal aberrations and single gene variants responsible for RPL, which provides new insight into its pathogenic mechanisms. Furthermore, based upon patients’ diagnostic evaluation and etiologic diagnosis, specific therapeutic recommendations have been established. This review will highlight current understanding and recent advances on RPL, with a special focus on the immunological and genetic etiologies, clinical diagnosis and therapeutic management. |
| first_indexed | 2024-04-09T18:31:51Z |
| format | Article |
| id | doaj.art-4db310d85efe47d69b6930be46c655dc |
| institution | Directory Open Access Journal |
| issn | 2749-9642 |
| language | English |
| last_indexed | 2024-04-09T18:31:51Z |
| publishDate | 2022-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Medical Review |
| spelling | doaj.art-4db310d85efe47d69b6930be46c655dc2023-04-11T17:07:17ZengDe GruyterMedical Review2749-96422022-12-012657058910.1515/mr-2022-0030Understanding recurrent pregnancy loss: recent advances on its etiology, clinical diagnosis, and managementCao Chunwei0Bai Shiyu1Zhang Jing2Sun Xiaoyue3Meng Anming4Chen Hui5Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangdong Province, ChinaReproductive Medicine Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, ChinaMedical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangdong Province, ChinaMedical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangdong Province, ChinaGuangzhou laboratory, Guangzhou, Guangdong Province, ChinaReproductive Medicine Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, ChinaRecurrent pregnancy loss (RPL) has become an important reproductive health issue worldwide. RPL affects about 2%–3% of reproductive-aged women, and makes serious threats to women’s physical and mental health. However, the etiology of approximately 50% of RPL cases remains unknown (unexplained RPL), which poses a big challenge for clinical management of these patients. RPL has been widely regarded as a complex disease where its etiology has been attributed to numerous factors. Heretofore, various risk factors for RPL have been identified, such as maternal ages, genetic factors, anatomical structural abnormalities, endocrine dysfunction, prethrombotic state, immunological factors, and infection. More importantly, development and applications of next generation sequencing technology have significantly expanded opportunities to discover chromosomal aberrations and single gene variants responsible for RPL, which provides new insight into its pathogenic mechanisms. Furthermore, based upon patients’ diagnostic evaluation and etiologic diagnosis, specific therapeutic recommendations have been established. This review will highlight current understanding and recent advances on RPL, with a special focus on the immunological and genetic etiologies, clinical diagnosis and therapeutic management.https://doi.org/10.1515/mr-2022-0030etiologic diagnosisgenetic etiologynext generation sequencingrecurrent pregnancy losstherapeutic recommendations |
| spellingShingle | Cao Chunwei Bai Shiyu Zhang Jing Sun Xiaoyue Meng Anming Chen Hui Understanding recurrent pregnancy loss: recent advances on its etiology, clinical diagnosis, and management Medical Review etiologic diagnosis genetic etiology next generation sequencing recurrent pregnancy loss therapeutic recommendations |
| title | Understanding recurrent pregnancy loss: recent advances on its etiology, clinical diagnosis, and management |
| title_full | Understanding recurrent pregnancy loss: recent advances on its etiology, clinical diagnosis, and management |
| title_fullStr | Understanding recurrent pregnancy loss: recent advances on its etiology, clinical diagnosis, and management |
| title_full_unstemmed | Understanding recurrent pregnancy loss: recent advances on its etiology, clinical diagnosis, and management |
| title_short | Understanding recurrent pregnancy loss: recent advances on its etiology, clinical diagnosis, and management |
| title_sort | understanding recurrent pregnancy loss recent advances on its etiology clinical diagnosis and management |
| topic | etiologic diagnosis genetic etiology next generation sequencing recurrent pregnancy loss therapeutic recommendations |
| url | https://doi.org/10.1515/mr-2022-0030 |
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