Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses
CTL responses are critical in protection against pathogens. Here, using mass spectrometry and flow cytometry, the authors characterize the kinetics of influenza A virus class I MHC epitopes cross-presented in professional antigen presenting cells and identify new epitopes that elicit T cell response...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10661-8 |
| _version_ | 1819202392040669184 |
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| author | Ting Wu Jing Guan Andreas Handel David C. Tscharke John Sidney Alessandro Sette Linda M. Wakim Xavier Y. X. Sng Paul G. Thomas Nathan P. Croft Anthony W. Purcell Nicole L. La Gruta |
| author_facet | Ting Wu Jing Guan Andreas Handel David C. Tscharke John Sidney Alessandro Sette Linda M. Wakim Xavier Y. X. Sng Paul G. Thomas Nathan P. Croft Anthony W. Purcell Nicole L. La Gruta |
| author_sort | Ting Wu |
| collection | DOAJ |
| description | CTL responses are critical in protection against pathogens. Here, using mass spectrometry and flow cytometry, the authors characterize the kinetics of influenza A virus class I MHC epitopes cross-presented in professional antigen presenting cells and identify new epitopes that elicit T cell responses in infected mice. |
| first_indexed | 2024-12-23T04:03:17Z |
| format | Article |
| id | doaj.art-4db3dda319094990b8faec74a9a13815 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T04:03:17Z |
| publishDate | 2019-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4db3dda319094990b8faec74a9a138152022-12-21T18:00:40ZengNature PortfolioNature Communications2041-17232019-06-0110111410.1038/s41467-019-10661-8Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responsesTing Wu0Jing Guan1Andreas Handel2David C. Tscharke3John Sidney4Alessandro Sette5Linda M. Wakim6Xavier Y. X. Sng7Paul G. Thomas8Nathan P. Croft9Anthony W. Purcell10Nicole L. La Gruta11Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash UniversityMonash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash UniversityDepartment of Epidemiology and Biostatistics, Health Informatics Institute and Center for the Ecology of Infectious Diseases, University of GeorgiaJohn Curtin School of Medical Research, The Australian National UniversityDivision of Vaccine Discovery, La Jolla Institute for Allergy and ImmunologyDivision of Vaccine Discovery, La Jolla Institute for Allergy and ImmunologyDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of MelbourneMonash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash UniversityDepartment of Immunology, St Jude Children’s Research HospitalMonash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash UniversityMonash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash UniversityMonash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash UniversityCTL responses are critical in protection against pathogens. Here, using mass spectrometry and flow cytometry, the authors characterize the kinetics of influenza A virus class I MHC epitopes cross-presented in professional antigen presenting cells and identify new epitopes that elicit T cell responses in infected mice.https://doi.org/10.1038/s41467-019-10661-8 |
| spellingShingle | Ting Wu Jing Guan Andreas Handel David C. Tscharke John Sidney Alessandro Sette Linda M. Wakim Xavier Y. X. Sng Paul G. Thomas Nathan P. Croft Anthony W. Purcell Nicole L. La Gruta Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses Nature Communications |
| title | Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses |
| title_full | Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses |
| title_fullStr | Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses |
| title_full_unstemmed | Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses |
| title_short | Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses |
| title_sort | quantification of epitope abundance reveals the effect of direct and cross presentation on influenza ctl responses |
| url | https://doi.org/10.1038/s41467-019-10661-8 |
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