Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

CTL responses are critical in protection against pathogens. Here, using mass spectrometry and flow cytometry, the authors characterize the kinetics of influenza A virus class I MHC epitopes cross-presented in professional antigen presenting cells and identify new epitopes that elicit T cell response...

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Bibliographic Details
Main Authors: Ting Wu, Jing Guan, Andreas Handel, David C. Tscharke, John Sidney, Alessandro Sette, Linda M. Wakim, Xavier Y. X. Sng, Paul G. Thomas, Nathan P. Croft, Anthony W. Purcell, Nicole L. La Gruta
Format: Article
Language:English
Published: Nature Portfolio 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10661-8

Internet

https://doi.org/10.1038/s41467-019-10661-8

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