Diagnostic value of retinol-binding protein 4 in diabetic nephropathy: a systematic review and meta-analysis
ObjectiveDiabetic nephropathy (DN) is a major microvascular complication of diabetes and the leading cause of end-stage renal disease. Early detection and prevention of DN are important. Retinol-binding protein 4 (RBP4) has been considered as a single diagnostic marker for the detection of renal imp...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1356131/full |
| _version_ | 1797198709615755264 |
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| author | Xiaodan Cao Guanghui Zhong Tinglong Jin Weijiao Hu Jin Wang Bo Shi Renxiong Wei |
| author_facet | Xiaodan Cao Guanghui Zhong Tinglong Jin Weijiao Hu Jin Wang Bo Shi Renxiong Wei |
| author_sort | Xiaodan Cao |
| collection | DOAJ |
| description | ObjectiveDiabetic nephropathy (DN) is a major microvascular complication of diabetes and the leading cause of end-stage renal disease. Early detection and prevention of DN are important. Retinol-binding protein 4 (RBP4) has been considered as a single diagnostic marker for the detection of renal impairment. However, the results have been inconsistent. The present meta-analysis aimed to determine the diagnostic potential of RBP4 in patients in type 2 diabetes mellitus (T2DM) with DN.MethodsWe searched PubMed, Web of Science, Embase, Wanfang and CNKI databases from inception until January 2024. The meta-analysis was performed by Stata version 15.0, and sensitivity, specificity, positive and negative likelihood ratios (PLR and NLR), diagnostic odds ratio (DOR) and area under the curve (AUC) were pooled. The Quality Assessment of Diagnostic Accuracy Studies-2 tool was utilized to assess the quality of each included study. In addition, heterogeneity and publication bias were evaluated.ResultsTwenty-nine studies were included in the meta-analysis. The pooled sensitivity and specificity were 0.76 [95% confidence interval (CI), 0.71–0.80] and 0.81 (95% CI, 0.76–0.85), respectively. The results showed a pooled PLR of 4.06 (95% CI, 3.16–5.21), NLR of 0.29 (95% CI, 0.24–0.36) and DOR of 13.76 (95% CI, 9.29–20.37). The area under the summarized receiver operating characteristic curve was given a value of 0.85 (95% CI, 0.82–0.88). No obvious publication bias existed in the Deeks’ funnel plot asymmetry test.ConclusionOur findings suggest that RBP4 has a promising diagnostic value with good sensitivity and specificity for patients with T2DM with DN. |
| first_indexed | 2024-04-24T07:04:10Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-24T07:04:10Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-4db4f15a0e3c450b8219a4d37be650c82024-04-22T05:04:06ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-04-011510.3389/fendo.2024.13561311356131Diagnostic value of retinol-binding protein 4 in diabetic nephropathy: a systematic review and meta-analysisXiaodan Cao0Guanghui Zhong1Tinglong Jin2Weijiao Hu3Jin Wang4Bo Shi5Renxiong Wei6Department of Clinical Laboratory, Ningbo Municipal Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang Chinese Medical University, Ningbo, ChinaDepartment of Nephrology, Ningbo Municipal Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang Chinese Medical University, Ningbo, ChinaDepartment of Endocrinology, Ningbo Municipal Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang Chinese Medical University, Ningbo, ChinaDepartment of Clinical Laboratory, Ningbo Municipal Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang Chinese Medical University, Ningbo, ChinaDepartment of Endocrinology, Ningbo Municipal Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang Chinese Medical University, Ningbo, ChinaDepartment of Clinical Laboratory, Ningbo Municipal Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang Chinese Medical University, Ningbo, ChinaDepartment of Clinical Laboratory, Ningbo Municipal Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang Chinese Medical University, Ningbo, ChinaObjectiveDiabetic nephropathy (DN) is a major microvascular complication of diabetes and the leading cause of end-stage renal disease. Early detection and prevention of DN are important. Retinol-binding protein 4 (RBP4) has been considered as a single diagnostic marker for the detection of renal impairment. However, the results have been inconsistent. The present meta-analysis aimed to determine the diagnostic potential of RBP4 in patients in type 2 diabetes mellitus (T2DM) with DN.MethodsWe searched PubMed, Web of Science, Embase, Wanfang and CNKI databases from inception until January 2024. The meta-analysis was performed by Stata version 15.0, and sensitivity, specificity, positive and negative likelihood ratios (PLR and NLR), diagnostic odds ratio (DOR) and area under the curve (AUC) were pooled. The Quality Assessment of Diagnostic Accuracy Studies-2 tool was utilized to assess the quality of each included study. In addition, heterogeneity and publication bias were evaluated.ResultsTwenty-nine studies were included in the meta-analysis. The pooled sensitivity and specificity were 0.76 [95% confidence interval (CI), 0.71–0.80] and 0.81 (95% CI, 0.76–0.85), respectively. The results showed a pooled PLR of 4.06 (95% CI, 3.16–5.21), NLR of 0.29 (95% CI, 0.24–0.36) and DOR of 13.76 (95% CI, 9.29–20.37). The area under the summarized receiver operating characteristic curve was given a value of 0.85 (95% CI, 0.82–0.88). No obvious publication bias existed in the Deeks’ funnel plot asymmetry test.ConclusionOur findings suggest that RBP4 has a promising diagnostic value with good sensitivity and specificity for patients with T2DM with DN.https://www.frontiersin.org/articles/10.3389/fendo.2024.1356131/fullretinol-binding protein 4diabetic nephropathydiagnosisbiomarkersmeta-analysis |
| spellingShingle | Xiaodan Cao Guanghui Zhong Tinglong Jin Weijiao Hu Jin Wang Bo Shi Renxiong Wei Diagnostic value of retinol-binding protein 4 in diabetic nephropathy: a systematic review and meta-analysis Frontiers in Endocrinology retinol-binding protein 4 diabetic nephropathy diagnosis biomarkers meta-analysis |
| title | Diagnostic value of retinol-binding protein 4 in diabetic nephropathy: a systematic review and meta-analysis |
| title_full | Diagnostic value of retinol-binding protein 4 in diabetic nephropathy: a systematic review and meta-analysis |
| title_fullStr | Diagnostic value of retinol-binding protein 4 in diabetic nephropathy: a systematic review and meta-analysis |
| title_full_unstemmed | Diagnostic value of retinol-binding protein 4 in diabetic nephropathy: a systematic review and meta-analysis |
| title_short | Diagnostic value of retinol-binding protein 4 in diabetic nephropathy: a systematic review and meta-analysis |
| title_sort | diagnostic value of retinol binding protein 4 in diabetic nephropathy a systematic review and meta analysis |
| topic | retinol-binding protein 4 diabetic nephropathy diagnosis biomarkers meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1356131/full |
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