Unsupervised Mining of HLA-I Peptidomes Reveals New Binding Motifs and Potential False Positives in the Community Database

Unsupervised Mining of HLA-I Peptidomes Reveals New Binding Motifs and Potential False Positives in the Community Database

Modern vaccine designs and studies of human leukocyte antigen (HLA)-mediated immune responses rely heavily on the knowledge of HLA allele-specific binding motifs and computational prediction of HLA-peptide binding affinity. Breakthroughs in HLA peptidomics have considerably expanded the databases of...

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Bibliographic Details
Main Authors: Chatchapon Sricharoensuk, Tanupat Boonchalermvichien, Phijitra Muanwien, Poorichaya Somparn, Trairak Pisitkun, Sira Sriswasdi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
HLA class I
De novo peptide sequencing
HLA binding motifs
HLA peptidomics
IEDB
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.847756/full

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