Oxidative DNA Damage from Nanoparticle Exposure and Its Application to Workers' Health: A Literature Review
The use of nanoparticles (NPs) in industry is increasing, bringing with it a number of adverse health effects on workers. Like other chemical carcinogens, NPs can cause cancer via oxidative DNA damage. Of all the molecules vulnerable to oxidative modification by NPs, DNA has received the greatest at...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2013-12-01
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| Series: | Safety and Health at Work |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2093791113000310 |
| _version_ | 1797764786794004480 |
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| author | Kyung-Taek Rim Se-Wook Song Hyeon-Yeong Kim |
| author_facet | Kyung-Taek Rim Se-Wook Song Hyeon-Yeong Kim |
| author_sort | Kyung-Taek Rim |
| collection | DOAJ |
| description | The use of nanoparticles (NPs) in industry is increasing, bringing with it a number of adverse health effects on workers. Like other chemical carcinogens, NPs can cause cancer via oxidative DNA damage. Of all the molecules vulnerable to oxidative modification by NPs, DNA has received the greatest attention, and biomarkers of exposure and effect are nearing validation. This review concentrates on studies published between 2000 and 2012 that attempted to detect oxidative DNA damage in humans, laboratory animals, and cell lines. It is important to review these studies to improve the current understanding of the oxidative DNA damage caused by NP exposure in the workplace. In addition to examining studies on oxidative damage, this review briefly describes NPs, giving some examples of their adverse effects, and reviews occupational exposure assessments and approaches to minimizing exposure (e.g., personal protective equipment and engineering controls such as fume hoods). Current recommendations to minimize exposure are largely based on common sense, analogy to ultrafine material toxicity, and general health and safety recommendations. |
| first_indexed | 2024-03-12T20:01:48Z |
| format | Article |
| id | doaj.art-4db624e5ced24a53bcd9a2772d37a8cb |
| institution | Directory Open Access Journal |
| issn | 2093-7911 |
| language | English |
| last_indexed | 2024-03-12T20:01:48Z |
| publishDate | 2013-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Safety and Health at Work |
| spelling | doaj.art-4db624e5ced24a53bcd9a2772d37a8cb2023-08-02T02:22:24ZengElsevierSafety and Health at Work2093-79112013-12-014417718610.1016/j.shaw.2013.07.006Oxidative DNA Damage from Nanoparticle Exposure and Its Application to Workers' Health: A Literature ReviewKyung-Taek RimSe-Wook SongHyeon-Yeong KimThe use of nanoparticles (NPs) in industry is increasing, bringing with it a number of adverse health effects on workers. Like other chemical carcinogens, NPs can cause cancer via oxidative DNA damage. Of all the molecules vulnerable to oxidative modification by NPs, DNA has received the greatest attention, and biomarkers of exposure and effect are nearing validation. This review concentrates on studies published between 2000 and 2012 that attempted to detect oxidative DNA damage in humans, laboratory animals, and cell lines. It is important to review these studies to improve the current understanding of the oxidative DNA damage caused by NP exposure in the workplace. In addition to examining studies on oxidative damage, this review briefly describes NPs, giving some examples of their adverse effects, and reviews occupational exposure assessments and approaches to minimizing exposure (e.g., personal protective equipment and engineering controls such as fume hoods). Current recommendations to minimize exposure are largely based on common sense, analogy to ultrafine material toxicity, and general health and safety recommendations.http://www.sciencedirect.com/science/article/pii/S2093791113000310DNA damagehealthnanoparticle exposureoccupational safetyworkers |
| spellingShingle | Kyung-Taek Rim Se-Wook Song Hyeon-Yeong Kim Oxidative DNA Damage from Nanoparticle Exposure and Its Application to Workers' Health: A Literature Review Safety and Health at Work DNA damage health nanoparticle exposure occupational safety workers |
| title | Oxidative DNA Damage from Nanoparticle Exposure and Its Application to Workers' Health: A Literature Review |
| title_full | Oxidative DNA Damage from Nanoparticle Exposure and Its Application to Workers' Health: A Literature Review |
| title_fullStr | Oxidative DNA Damage from Nanoparticle Exposure and Its Application to Workers' Health: A Literature Review |
| title_full_unstemmed | Oxidative DNA Damage from Nanoparticle Exposure and Its Application to Workers' Health: A Literature Review |
| title_short | Oxidative DNA Damage from Nanoparticle Exposure and Its Application to Workers' Health: A Literature Review |
| title_sort | oxidative dna damage from nanoparticle exposure and its application to workers health a literature review |
| topic | DNA damage health nanoparticle exposure occupational safety workers |
| url | http://www.sciencedirect.com/science/article/pii/S2093791113000310 |
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