<i>Enterovirus D</i>: A Small but Versatile Species
Enteroviruses (EVs) from the D species are the causative agents of a diverse range of infectious diseases in spite of comprising only five known members. This small clade has a diverse host range and tissue tropism. It contains types infecting non-human primates and/or humans, and for the latter, th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/9/8/1758 |
| _version_ | 1797522770988367872 |
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| author | Ines Cordeiro Filipe Mariana Soares Guedes Evgeny M. Zdobnov Caroline Tapparel |
| author_facet | Ines Cordeiro Filipe Mariana Soares Guedes Evgeny M. Zdobnov Caroline Tapparel |
| author_sort | Ines Cordeiro Filipe |
| collection | DOAJ |
| description | Enteroviruses (EVs) from the D species are the causative agents of a diverse range of infectious diseases in spite of comprising only five known members. This small clade has a diverse host range and tissue tropism. It contains types infecting non-human primates and/or humans, and for the latter, they preferentially infect the eye, respiratory tract, gastrointestinal tract, and nervous system. Although several <i>Enterovirus D</i> members, in particular EV-D68, have been associated with neurological complications, including acute myelitis, there is currently no effective treatment or vaccine against any of them. This review highlights the peculiarities of this viral species, focusing on genome organization, functional elements, receptor usage, and pathogenesis. |
| first_indexed | 2024-03-10T08:34:04Z |
| format | Article |
| id | doaj.art-4db654d6a8524b20832b391df7d413b7 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T08:34:04Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-4db654d6a8524b20832b391df7d413b72023-11-22T08:48:26ZengMDPI AGMicroorganisms2076-26072021-08-0198175810.3390/microorganisms9081758<i>Enterovirus D</i>: A Small but Versatile SpeciesInes Cordeiro Filipe0Mariana Soares Guedes1Evgeny M. Zdobnov2Caroline Tapparel3Department of Microbiology and Molecular Medicine, University of Geneva, 1206 Geneva, SwitzerlandDepartment of Microbiology and Molecular Medicine, University of Geneva, 1206 Geneva, SwitzerlandDepartment of Genetic Medicine and Development, Switzerland and Swiss Institute of Bioinformatics, University of Geneva, 1206 Geneva, SwitzerlandDepartment of Microbiology and Molecular Medicine, University of Geneva, 1206 Geneva, SwitzerlandEnteroviruses (EVs) from the D species are the causative agents of a diverse range of infectious diseases in spite of comprising only five known members. This small clade has a diverse host range and tissue tropism. It contains types infecting non-human primates and/or humans, and for the latter, they preferentially infect the eye, respiratory tract, gastrointestinal tract, and nervous system. Although several <i>Enterovirus D</i> members, in particular EV-D68, have been associated with neurological complications, including acute myelitis, there is currently no effective treatment or vaccine against any of them. This review highlights the peculiarities of this viral species, focusing on genome organization, functional elements, receptor usage, and pathogenesis.https://www.mdpi.com/2076-2607/9/8/1758<i>Enterovirus</i><i>Enterovirus D</i>EV-D68EV-D70EV-D94EV-D111 |
| spellingShingle | Ines Cordeiro Filipe Mariana Soares Guedes Evgeny M. Zdobnov Caroline Tapparel <i>Enterovirus D</i>: A Small but Versatile Species Microorganisms <i>Enterovirus</i> <i>Enterovirus D</i> EV-D68 EV-D70 EV-D94 EV-D111 |
| title | <i>Enterovirus D</i>: A Small but Versatile Species |
| title_full | <i>Enterovirus D</i>: A Small but Versatile Species |
| title_fullStr | <i>Enterovirus D</i>: A Small but Versatile Species |
| title_full_unstemmed | <i>Enterovirus D</i>: A Small but Versatile Species |
| title_short | <i>Enterovirus D</i>: A Small but Versatile Species |
| title_sort | i enterovirus d i a small but versatile species |
| topic | <i>Enterovirus</i> <i>Enterovirus D</i> EV-D68 EV-D70 EV-D94 EV-D111 |
| url | https://www.mdpi.com/2076-2607/9/8/1758 |
| work_keys_str_mv | AT inescordeirofilipe ienterovirusdiasmallbutversatilespecies AT marianasoaresguedes ienterovirusdiasmallbutversatilespecies AT evgenymzdobnov ienterovirusdiasmallbutversatilespecies AT carolinetapparel ienterovirusdiasmallbutversatilespecies |