Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia
Stent implantation impairs local endothelial function and may be associated with subsequent adverse cardiovascular events. Telmisartan, an angiotensin II receptor blocker that has unique peroxisome proliferator-activated-receptor-gamma-mediated effects on cardiovascular disease, has been shown to en...
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MDPI AG
2021-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/11/1756 |
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| author | Chen-Hung Lee Kuo-Sheng Liu Julien George Roth Kuo-Chun Hung Yen-Wei Liu Shin-Huei Wang Chi-Ching Kuo Shih-Jung Liu |
| author_facet | Chen-Hung Lee Kuo-Sheng Liu Julien George Roth Kuo-Chun Hung Yen-Wei Liu Shin-Huei Wang Chi-Ching Kuo Shih-Jung Liu |
| author_sort | Chen-Hung Lee |
| collection | DOAJ |
| description | Stent implantation impairs local endothelial function and may be associated with subsequent adverse cardiovascular events. Telmisartan, an angiotensin II receptor blocker that has unique peroxisome proliferator-activated-receptor-gamma-mediated effects on cardiovascular disease, has been shown to enhance endothelial function and limit neointimal hyperplasia. This study utilized hybrid biodegradable/stent nanofibers to facilitate sustained and local delivery of telmisartan to injured arterial vessels. Telmisartan and poly(<span style="font-variant: small-caps;">d,l</span>)-lactide-<i>co</i>-glycolide (PLGA) (75:25) were dissolved in hexafluoroisopropyl alcohol and electrospun into biodegradable nanofibrous tubes which were coated onto metal stents. By releasing 20% of the loaded telmisartan in 30 days, these hybrid biodegradable/stent telmisartan-loaded nanofibers increased the migration of endothelial progenitor cells in vitro, promoted endothelialization, and reduced intimal hyperplasia. As such, this work provides insights into the use of PLGA nanofibers for treating patients with an increased risk of stent restenosis. |
| first_indexed | 2024-03-10T05:08:51Z |
| format | Article |
| id | doaj.art-4db7564bc9ae48a28ddd05095c219495 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T05:08:51Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-4db7564bc9ae48a28ddd05095c2194952023-11-23T00:57:07ZengMDPI AGPharmaceutics1999-49232021-10-011311175610.3390/pharmaceutics13111756Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal HyperplasiaChen-Hung Lee0Kuo-Sheng Liu1Julien George Roth2Kuo-Chun Hung3Yen-Wei Liu4Shin-Huei Wang5Chi-Ching Kuo6Shih-Jung Liu7Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Chang Gung University College of Medicine, Taoyuan 33305, TaiwanDepartment of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Taoyuan 33305, TaiwanInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USADivision of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Chang Gung University College of Medicine, Taoyuan 33305, TaiwanDivision of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Chang Gung University College of Medicine, Taoyuan 33305, TaiwanDivision of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Chang Gung University College of Medicine, Taoyuan 33305, TaiwanResearch and Development Center of Smart Textile Technology, Institute of Organic and Polymeric Materials, National Taipei University of Technology, Taipei 10608, TaiwanDepartment of Mechanical Engineering, Chang Gung University, Taoyuan 33302, TaiwanStent implantation impairs local endothelial function and may be associated with subsequent adverse cardiovascular events. Telmisartan, an angiotensin II receptor blocker that has unique peroxisome proliferator-activated-receptor-gamma-mediated effects on cardiovascular disease, has been shown to enhance endothelial function and limit neointimal hyperplasia. This study utilized hybrid biodegradable/stent nanofibers to facilitate sustained and local delivery of telmisartan to injured arterial vessels. Telmisartan and poly(<span style="font-variant: small-caps;">d,l</span>)-lactide-<i>co</i>-glycolide (PLGA) (75:25) were dissolved in hexafluoroisopropyl alcohol and electrospun into biodegradable nanofibrous tubes which were coated onto metal stents. By releasing 20% of the loaded telmisartan in 30 days, these hybrid biodegradable/stent telmisartan-loaded nanofibers increased the migration of endothelial progenitor cells in vitro, promoted endothelialization, and reduced intimal hyperplasia. As such, this work provides insights into the use of PLGA nanofibers for treating patients with an increased risk of stent restenosis.https://www.mdpi.com/1999-4923/13/11/1756drug-loaded nanofiberstelmisartanPLGAcontrolled release |
| spellingShingle | Chen-Hung Lee Kuo-Sheng Liu Julien George Roth Kuo-Chun Hung Yen-Wei Liu Shin-Huei Wang Chi-Ching Kuo Shih-Jung Liu Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia Pharmaceutics drug-loaded nanofibers telmisartan PLGA controlled release |
| title | Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia |
| title_full | Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia |
| title_fullStr | Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia |
| title_full_unstemmed | Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia |
| title_short | Telmisartan Loaded Nanofibers Enhance Re-Endothelialization and Inhibit Neointimal Hyperplasia |
| title_sort | telmisartan loaded nanofibers enhance re endothelialization and inhibit neointimal hyperplasia |
| topic | drug-loaded nanofibers telmisartan PLGA controlled release |
| url | https://www.mdpi.com/1999-4923/13/11/1756 |
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