Understanding the Functional Properties of Neonatal Dendritic Cells: A Doorway to Enhance Vaccine Effectiveness?
Increased susceptibility to infectious diseases is a hallmark of the neonatal period of life that is generally attributed to a relative immaturity of the immune system. Dendritic cells (DCs) are innate immune sentinels with vital roles in the initiation and orchestration of immune responses, thus, c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.03123/full |
| _version_ | 1818961779264323584 |
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| author | Nikos E. Papaioannou Maria Pasztoi Barbara U. Schraml Barbara U. Schraml |
| author_facet | Nikos E. Papaioannou Maria Pasztoi Barbara U. Schraml Barbara U. Schraml |
| author_sort | Nikos E. Papaioannou |
| collection | DOAJ |
| description | Increased susceptibility to infectious diseases is a hallmark of the neonatal period of life that is generally attributed to a relative immaturity of the immune system. Dendritic cells (DCs) are innate immune sentinels with vital roles in the initiation and orchestration of immune responses, thus, constituting a promising target for promoting neonatal immunity. However, as is the case for other immune cells, neonatal DCs have been suggested to be functionally immature compared to their adult counterparts. Here we review some of the unique aspects of neonatal DCs that shape immune responses in early life and speculate whether the functional properties of neonatal DCs could be exploited or manipulated to promote more effective vaccination in early life. |
| first_indexed | 2024-12-20T12:18:51Z |
| format | Article |
| id | doaj.art-4db9c504778a4ecf8e20b39095c27938 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-20T12:18:51Z |
| publishDate | 2019-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-4db9c504778a4ecf8e20b39095c279382022-12-21T19:41:02ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-01-01910.3389/fimmu.2018.03123421591Understanding the Functional Properties of Neonatal Dendritic Cells: A Doorway to Enhance Vaccine Effectiveness?Nikos E. Papaioannou0Maria Pasztoi1Barbara U. Schraml2Barbara U. Schraml3Biomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-University Munich, Munich, GermanyBiomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-University Munich, Munich, GermanyBiomedical Center, Institute for Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-University Munich, Munich, GermanyWalter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig-Maximilians-University Munich, Munich, GermanyIncreased susceptibility to infectious diseases is a hallmark of the neonatal period of life that is generally attributed to a relative immaturity of the immune system. Dendritic cells (DCs) are innate immune sentinels with vital roles in the initiation and orchestration of immune responses, thus, constituting a promising target for promoting neonatal immunity. However, as is the case for other immune cells, neonatal DCs have been suggested to be functionally immature compared to their adult counterparts. Here we review some of the unique aspects of neonatal DCs that shape immune responses in early life and speculate whether the functional properties of neonatal DCs could be exploited or manipulated to promote more effective vaccination in early life.https://www.frontiersin.org/article/10.3389/fimmu.2018.03123/fulldendritic cell (DC)DC subsetsearly life immunityvaccinationimmune system developmentT cell activation |
| spellingShingle | Nikos E. Papaioannou Maria Pasztoi Barbara U. Schraml Barbara U. Schraml Understanding the Functional Properties of Neonatal Dendritic Cells: A Doorway to Enhance Vaccine Effectiveness? Frontiers in Immunology dendritic cell (DC) DC subsets early life immunity vaccination immune system development T cell activation |
| title | Understanding the Functional Properties of Neonatal Dendritic Cells: A Doorway to Enhance Vaccine Effectiveness? |
| title_full | Understanding the Functional Properties of Neonatal Dendritic Cells: A Doorway to Enhance Vaccine Effectiveness? |
| title_fullStr | Understanding the Functional Properties of Neonatal Dendritic Cells: A Doorway to Enhance Vaccine Effectiveness? |
| title_full_unstemmed | Understanding the Functional Properties of Neonatal Dendritic Cells: A Doorway to Enhance Vaccine Effectiveness? |
| title_short | Understanding the Functional Properties of Neonatal Dendritic Cells: A Doorway to Enhance Vaccine Effectiveness? |
| title_sort | understanding the functional properties of neonatal dendritic cells a doorway to enhance vaccine effectiveness |
| topic | dendritic cell (DC) DC subsets early life immunity vaccination immune system development T cell activation |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.03123/full |
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