Delirium Induced by Quetiapine and the Potential Role of Norquetiapine
Quetiapine in an atypical antipsychotic drug that is frequently used for delirium and behavioral and psychological symptoms in dementia. However, its potential anticholinergic effects, mediated primarily through its metabolite norquetiapine, could present as counterproductive adverse effects in thes...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-08-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.00886/full |
| _version_ | 1818594818057568256 |
|---|---|
| author | Filipe Almeida Filipe Almeida Elisabete Albuquerque Ilda Murta |
| author_facet | Filipe Almeida Filipe Almeida Elisabete Albuquerque Ilda Murta |
| author_sort | Filipe Almeida |
| collection | DOAJ |
| description | Quetiapine in an atypical antipsychotic drug that is frequently used for delirium and behavioral and psychological symptoms in dementia. However, its potential anticholinergic effects, mediated primarily through its metabolite norquetiapine, could present as counterproductive adverse effects in these situations. There is little data published discussing this potential negative impact on quetiapine’s safety and tolerability, especially in the elderly. Here, we present what is, to our knowledge, the first published case report of delirium apparently induced by low-dose quetiapine, in a 95-year-old patient with no prior history of mental illness, and the potential role of its metabolite norquetiapine. |
| first_indexed | 2024-12-16T11:06:09Z |
| format | Article |
| id | doaj.art-4dbd29f45b6d468cb197c91d43064ec5 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-16T11:06:09Z |
| publishDate | 2019-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-4dbd29f45b6d468cb197c91d43064ec52022-12-21T22:33:51ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-08-011310.3389/fnins.2019.00886468839Delirium Induced by Quetiapine and the Potential Role of NorquetiapineFilipe Almeida0Filipe Almeida1Elisabete Albuquerque2Ilda Murta3Department of Psychiatry, The Coimbra Hospital and University Centre, Coimbra, PortugalFaculty of Medicine, University of Coimbra, Coimbra, PortugalDepartment of Psychiatry, The Coimbra Hospital and University Centre, Coimbra, PortugalDepartment of Psychiatry, The Coimbra Hospital and University Centre, Coimbra, PortugalQuetiapine in an atypical antipsychotic drug that is frequently used for delirium and behavioral and psychological symptoms in dementia. However, its potential anticholinergic effects, mediated primarily through its metabolite norquetiapine, could present as counterproductive adverse effects in these situations. There is little data published discussing this potential negative impact on quetiapine’s safety and tolerability, especially in the elderly. Here, we present what is, to our knowledge, the first published case report of delirium apparently induced by low-dose quetiapine, in a 95-year-old patient with no prior history of mental illness, and the potential role of its metabolite norquetiapine.https://www.frontiersin.org/article/10.3389/fnins.2019.00886/fulldeliriumquetiapineanticholinergicantipsychoticsadverse effects |
| spellingShingle | Filipe Almeida Filipe Almeida Elisabete Albuquerque Ilda Murta Delirium Induced by Quetiapine and the Potential Role of Norquetiapine Frontiers in Neuroscience delirium quetiapine anticholinergic antipsychotics adverse effects |
| title | Delirium Induced by Quetiapine and the Potential Role of Norquetiapine |
| title_full | Delirium Induced by Quetiapine and the Potential Role of Norquetiapine |
| title_fullStr | Delirium Induced by Quetiapine and the Potential Role of Norquetiapine |
| title_full_unstemmed | Delirium Induced by Quetiapine and the Potential Role of Norquetiapine |
| title_short | Delirium Induced by Quetiapine and the Potential Role of Norquetiapine |
| title_sort | delirium induced by quetiapine and the potential role of norquetiapine |
| topic | delirium quetiapine anticholinergic antipsychotics adverse effects |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.00886/full |
| work_keys_str_mv | AT filipealmeida deliriuminducedbyquetiapineandthepotentialroleofnorquetiapine AT filipealmeida deliriuminducedbyquetiapineandthepotentialroleofnorquetiapine AT elisabetealbuquerque deliriuminducedbyquetiapineandthepotentialroleofnorquetiapine AT ildamurta deliriuminducedbyquetiapineandthepotentialroleofnorquetiapine |