Amino Acid Profiles in the Biological Fluids and Tumor Tissue of CRC Patients
Amino acids are the building blocks of proteins and essential players in pathways such as the citric acid and urea cycle, purine and pyrimidine biosynthesis, and redox cell signaling. Therefore, it is unsurprising that these molecules have a significant role in cancer metabolism and its metabolic pl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/16/1/69 |
| _version_ | 1797359067283324928 |
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| author | Marisa Domingues Santos Ivo Barros Pedro Brandão Lúcia Lacerda |
| author_facet | Marisa Domingues Santos Ivo Barros Pedro Brandão Lúcia Lacerda |
| author_sort | Marisa Domingues Santos |
| collection | DOAJ |
| description | Amino acids are the building blocks of proteins and essential players in pathways such as the citric acid and urea cycle, purine and pyrimidine biosynthesis, and redox cell signaling. Therefore, it is unsurprising that these molecules have a significant role in cancer metabolism and its metabolic plasticity. As one of the most prevalent malign diseases, colorectal cancer needs biomarkers for its early detection, prognostic, and prediction of response to therapy. However, the available biomarkers for this disease must be more powerful and present several drawbacks, such as high costs and complex laboratory procedures. Metabolomics has gathered substantial attention in the past two decades as a screening platform to study new metabolites, partly due to the development of techniques, such as mass spectrometry or liquid chromatography, which have become standard practice in diagnostic procedures for other diseases. Extensive metabolomic studies have been performed in colorectal cancer (CRC) patients in the past years, and several exciting results concerning amino acid metabolism have been found. This review aims to gather and present findings concerning alterations in the amino acid plasma pool of colorectal cancer patients. |
| first_indexed | 2024-03-08T15:10:18Z |
| format | Article |
| id | doaj.art-4dbd323c5f2c4ef99a56b3e07b0516a4 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-08T15:10:18Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4dbd323c5f2c4ef99a56b3e07b0516a42024-01-10T14:52:29ZengMDPI AGCancers2072-66942023-12-011616910.3390/cancers16010069Amino Acid Profiles in the Biological Fluids and Tumor Tissue of CRC PatientsMarisa Domingues Santos0Ivo Barros1Pedro Brandão2Lúcia Lacerda3Colorectal Unit, Hospital de Santo António, Centro Hospitalar Universitário de Santo António, 4050-651 Porto, PortugalUMIB—Unit for Multidisciplinary Research in Biomedicine, ICBAS—School of Medicine and Biomedical Sciences, University of Porto, 4050-313 Porto, PortugalColorectal Unit, Hospital de Santo António, Centro Hospitalar Universitário de Santo António, 4050-651 Porto, PortugalUMIB—Unit for Multidisciplinary Research in Biomedicine, ICBAS—School of Medicine and Biomedical Sciences, University of Porto, 4050-313 Porto, PortugalAmino acids are the building blocks of proteins and essential players in pathways such as the citric acid and urea cycle, purine and pyrimidine biosynthesis, and redox cell signaling. Therefore, it is unsurprising that these molecules have a significant role in cancer metabolism and its metabolic plasticity. As one of the most prevalent malign diseases, colorectal cancer needs biomarkers for its early detection, prognostic, and prediction of response to therapy. However, the available biomarkers for this disease must be more powerful and present several drawbacks, such as high costs and complex laboratory procedures. Metabolomics has gathered substantial attention in the past two decades as a screening platform to study new metabolites, partly due to the development of techniques, such as mass spectrometry or liquid chromatography, which have become standard practice in diagnostic procedures for other diseases. Extensive metabolomic studies have been performed in colorectal cancer (CRC) patients in the past years, and several exciting results concerning amino acid metabolism have been found. This review aims to gather and present findings concerning alterations in the amino acid plasma pool of colorectal cancer patients.https://www.mdpi.com/2072-6694/16/1/69colorectal cancerbiomarkersamino acidsmetabolomicsdiagnosisprognosis |
| spellingShingle | Marisa Domingues Santos Ivo Barros Pedro Brandão Lúcia Lacerda Amino Acid Profiles in the Biological Fluids and Tumor Tissue of CRC Patients Cancers colorectal cancer biomarkers amino acids metabolomics diagnosis prognosis |
| title | Amino Acid Profiles in the Biological Fluids and Tumor Tissue of CRC Patients |
| title_full | Amino Acid Profiles in the Biological Fluids and Tumor Tissue of CRC Patients |
| title_fullStr | Amino Acid Profiles in the Biological Fluids and Tumor Tissue of CRC Patients |
| title_full_unstemmed | Amino Acid Profiles in the Biological Fluids and Tumor Tissue of CRC Patients |
| title_short | Amino Acid Profiles in the Biological Fluids and Tumor Tissue of CRC Patients |
| title_sort | amino acid profiles in the biological fluids and tumor tissue of crc patients |
| topic | colorectal cancer biomarkers amino acids metabolomics diagnosis prognosis |
| url | https://www.mdpi.com/2072-6694/16/1/69 |
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