N-Substituted 5-Amino-6-methylpyrazine-2,3-dicarbonitriles: Microwave-Assisted Synthesis and Biological Properties

N-Substituted 5-Amino-6-methylpyrazine-2,3-dicarbonitriles: Microwave-Assisted Synthesis and Biological Properties

In this work a series of 15 N-benzylamine substituted 5-amino-6-methyl-pyrazine-2,3-dicarbonitriles was prepared by the aminodehalogenation reactions using microwave assisted synthesis with experimentally set and proven conditions. This approach for the aminodehalogenation reaction was chosen due to...

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Bibliographic Details
Main Authors: Ondrej Jandourek, Martin Dolezal, Pavla Paterova, Vladimir Kubicek, Matus Pesko, Jiri Kunes, Aidan Coffey, Jiahui Guo, Katarina Kralova
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:Molecules
Subjects:
pyrazinamide derivatives
in vitro biological evaluation
microwave-assisted synthesis
tuberculosis
lipophilicity
Online Access:http://www.mdpi.com/1420-3049/19/1/651

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