Association between handgrip strength and depressive symptoms in patients undergoing hemodialysis: a cross-sectional study from a single Chinese center
Abstract Background The relationship between handgrip strength (HGS) and depression in patients undergoing hemodialysis (HD) was unknown. Therefore, we aimed to clarify this association in a cohort of patients. Methods HGS was used as a representative indicator of muscle strength and was measured wi...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Psychiatry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12888-024-05576-8 |
| _version_ | 1797273662268637184 |
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| author | Shuang Zhang Shu-Xin Liu Qi-Jun Wu Zhi-Hong Wang Hong Liu Ping Xiao Yan Lu Cui Dong Qing-Mei Meng |
| author_facet | Shuang Zhang Shu-Xin Liu Qi-Jun Wu Zhi-Hong Wang Hong Liu Ping Xiao Yan Lu Cui Dong Qing-Mei Meng |
| author_sort | Shuang Zhang |
| collection | DOAJ |
| description | Abstract Background The relationship between handgrip strength (HGS) and depression in patients undergoing hemodialysis (HD) was unknown. Therefore, we aimed to clarify this association in a cohort of patients. Methods HGS was used as a representative indicator of muscle strength and was measured with a handheld dynamometer. Depressive symptoms were assessed with the self-reported Patient Health Questionnaire-9. A multivariable logistic regression model and restricted cubic spline analysis were used to assess the relationship between HGS and depression. Results The prevalence of depression in our study was 34% in 568 Chinese patients undergoing HD. Compared with patients in the lowest tertiles of absolute and weighted HGS, patients in the highest tertiles of HGS had an approximately 59% lower [odds ratio (OR) = 0.41, 95% confidence interval (CI) = 0.24–0.68; OR = 0.41, 95%CI = (0.24–0.69)] prevalence of depressive symptoms after multivariate adjustments. Besides, the risk of depression in hemodialysis patients decreased by 33% (OR = 0.67, 95%CI = 0.53–0.85) and 32% (OR = 0.68, 95%CI = 0.54–0.85) for each standard deviation increase in absolute HGS and weighted HGS, respectively. The prevalence of depressive symptoms decreased with both increasing absolute HGS and weighted HGS after multivariate adjustments (p for trend < 0.05). Furthermore, a linear dose-response relationship was observed between absolute HGS and weighted HGS and the prevalence of depressive symptoms (p nonlinearity>0.05). Conclusions This study suggests that lower handgrip strength, a simple and modifiable parameter, is associated with a higher prevalence of depression in Chinese patients undergoing HD. Considering that depression is often unrecognized or underdiagnosed in HD patients, lowered muscle strength should be an important indicator and incentive for medical staff to screen for depression. |
| first_indexed | 2024-03-07T14:47:32Z |
| format | Article |
| id | doaj.art-4dbebf8137f6404ab4f08cd9926a93dd |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-03-07T14:47:32Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-4dbebf8137f6404ab4f08cd9926a93dd2024-03-05T19:54:24ZengBMCBMC Psychiatry1471-244X2024-03-0124111110.1186/s12888-024-05576-8Association between handgrip strength and depressive symptoms in patients undergoing hemodialysis: a cross-sectional study from a single Chinese centerShuang Zhang0Shu-Xin Liu1Qi-Jun Wu2Zhi-Hong Wang3Hong Liu4Ping Xiao5Yan Lu6Cui Dong7Qing-Mei Meng8Department of Nephrology, Dalian Municipal Central HospitalDepartment of Nephrology, Dalian Municipal Central HospitalDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical UniversityDepartment of Nephrology, Dalian Municipal Central HospitalDepartment of Nephrology, Dalian Municipal Central HospitalDepartment of Nephrology, Dalian Municipal Central HospitalDepartment of Nephrology, Dalian Municipal Central HospitalDepartment of Nephrology, Dalian Municipal Central HospitalDepartment of Nephrology, Dalian Municipal Central HospitalAbstract Background The relationship between handgrip strength (HGS) and depression in patients undergoing hemodialysis (HD) was unknown. Therefore, we aimed to clarify this association in a cohort of patients. Methods HGS was used as a representative indicator of muscle strength and was measured with a handheld dynamometer. Depressive symptoms were assessed with the self-reported Patient Health Questionnaire-9. A multivariable logistic regression model and restricted cubic spline analysis were used to assess the relationship between HGS and depression. Results The prevalence of depression in our study was 34% in 568 Chinese patients undergoing HD. Compared with patients in the lowest tertiles of absolute and weighted HGS, patients in the highest tertiles of HGS had an approximately 59% lower [odds ratio (OR) = 0.41, 95% confidence interval (CI) = 0.24–0.68; OR = 0.41, 95%CI = (0.24–0.69)] prevalence of depressive symptoms after multivariate adjustments. Besides, the risk of depression in hemodialysis patients decreased by 33% (OR = 0.67, 95%CI = 0.53–0.85) and 32% (OR = 0.68, 95%CI = 0.54–0.85) for each standard deviation increase in absolute HGS and weighted HGS, respectively. The prevalence of depressive symptoms decreased with both increasing absolute HGS and weighted HGS after multivariate adjustments (p for trend < 0.05). Furthermore, a linear dose-response relationship was observed between absolute HGS and weighted HGS and the prevalence of depressive symptoms (p nonlinearity>0.05). Conclusions This study suggests that lower handgrip strength, a simple and modifiable parameter, is associated with a higher prevalence of depression in Chinese patients undergoing HD. Considering that depression is often unrecognized or underdiagnosed in HD patients, lowered muscle strength should be an important indicator and incentive for medical staff to screen for depression.https://doi.org/10.1186/s12888-024-05576-8Cross-sectional studyDepressive symptomsHandgrip strengthHemodialysis |
| spellingShingle | Shuang Zhang Shu-Xin Liu Qi-Jun Wu Zhi-Hong Wang Hong Liu Ping Xiao Yan Lu Cui Dong Qing-Mei Meng Association between handgrip strength and depressive symptoms in patients undergoing hemodialysis: a cross-sectional study from a single Chinese center BMC Psychiatry Cross-sectional study Depressive symptoms Handgrip strength Hemodialysis |
| title | Association between handgrip strength and depressive symptoms in patients undergoing hemodialysis: a cross-sectional study from a single Chinese center |
| title_full | Association between handgrip strength and depressive symptoms in patients undergoing hemodialysis: a cross-sectional study from a single Chinese center |
| title_fullStr | Association between handgrip strength and depressive symptoms in patients undergoing hemodialysis: a cross-sectional study from a single Chinese center |
| title_full_unstemmed | Association between handgrip strength and depressive symptoms in patients undergoing hemodialysis: a cross-sectional study from a single Chinese center |
| title_short | Association between handgrip strength and depressive symptoms in patients undergoing hemodialysis: a cross-sectional study from a single Chinese center |
| title_sort | association between handgrip strength and depressive symptoms in patients undergoing hemodialysis a cross sectional study from a single chinese center |
| topic | Cross-sectional study Depressive symptoms Handgrip strength Hemodialysis |
| url | https://doi.org/10.1186/s12888-024-05576-8 |
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