Synthesis, characterization and biological evaluation of novel ruthenium(II)-polypyridine mixed ligand complexes bearing 1,2,4- triazole-thiol moiety
The novel mixed ligand complexes [Ru(bpy)2(pytrzSH)2](PF6)2 (complex A) and [Ru(phen)2(pytrzSH)2](PF6)2 (complex B) (bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline and pytrzSH = 5-(3-pyridyl)-4H-1,2,4-triazole-3-thiol) has been synthesized and characterized by elemental analysis, UV, FTIR, 1H NMR...
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Elsevier
2024-06-01
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| Series: | Chemical Physics Impact |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667022423002633 |
| _version_ | 1797391711075303424 |
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| author | Santhiya S Arul Mary S Sheeba Daniel |
| author_facet | Santhiya S Arul Mary S Sheeba Daniel |
| author_sort | Santhiya S |
| collection | DOAJ |
| description | The novel mixed ligand complexes [Ru(bpy)2(pytrzSH)2](PF6)2 (complex A) and [Ru(phen)2(pytrzSH)2](PF6)2 (complex B) (bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline and pytrzSH = 5-(3-pyridyl)-4H-1,2,4-triazole-3-thiol) has been synthesized and characterized by elemental analysis, UV, FTIR, 1H NMR, 13C NMR and MALDI-TOF mass spectral techniques. The spectral data confirms the formation of octahedral complexes. The lipophilic nature of the complex is determined from the partition coefficient (log P) values and it is found to be 1.20 ± 0.004 for complex A and 1.86 ± 0.004 for complex B. The synthesised complexes show slight antimicrobial activities on S. aureus, P. aeruginosa, E. coli, A. niger and C. albicans. The α-glucosidase inhibitory activity of the synthesised complexes A and B against the positive control acarbose display IC50 value at 490.32 and 223.01 µg/mL. In vitro antiproliferative and cytotoxic effects of complexes A and B are analysed on SK-MEL-28 and non-tumoral L6 cell lines by microscopic and MTT assay methods. The IC50 for complexes A and B on SK-MEL-28 cancerous cell line are found to be 27.444 and 40.721 µg/mL and for non-tumoral L6 cells are 25.869 and 38.425 µg/mL respectively. The apoptotic study suggests that the synthesized complexes show late apoptotic effect on SK-MEL-28 cancerous cells and early apoptotic effect on non-tumoral L6 cells. Hence the obtained results suggest that the biological activities of the synthesised complexes depend on the nature of the ligands present in the complexes. |
| first_indexed | 2024-03-08T23:37:37Z |
| format | Article |
| id | doaj.art-4dbfb2dd8c9749ada469b1d003c3d1b2 |
| institution | Directory Open Access Journal |
| issn | 2667-0224 |
| language | English |
| last_indexed | 2024-03-08T23:37:37Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Chemical Physics Impact |
| spelling | doaj.art-4dbfb2dd8c9749ada469b1d003c3d1b22023-12-14T05:24:07ZengElsevierChemical Physics Impact2667-02242024-06-018100424Synthesis, characterization and biological evaluation of novel ruthenium(II)-polypyridine mixed ligand complexes bearing 1,2,4- triazole-thiol moietySanthiya S0Arul Mary S1Sheeba Daniel2Department of Science and Humanities, Narayanaguru College of Engineering, Manjalumoodu, Tamil Nadu, IndiaDepartment of Basic Engineering, Government Polytechnic College, Nagercoil, Tamil Nadu, IndiaDepartment of Chemistry, Holy Cross College (Autonomous), Nagercoil, Tamil Nadu, India; Corresponding author.The novel mixed ligand complexes [Ru(bpy)2(pytrzSH)2](PF6)2 (complex A) and [Ru(phen)2(pytrzSH)2](PF6)2 (complex B) (bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline and pytrzSH = 5-(3-pyridyl)-4H-1,2,4-triazole-3-thiol) has been synthesized and characterized by elemental analysis, UV, FTIR, 1H NMR, 13C NMR and MALDI-TOF mass spectral techniques. The spectral data confirms the formation of octahedral complexes. The lipophilic nature of the complex is determined from the partition coefficient (log P) values and it is found to be 1.20 ± 0.004 for complex A and 1.86 ± 0.004 for complex B. The synthesised complexes show slight antimicrobial activities on S. aureus, P. aeruginosa, E. coli, A. niger and C. albicans. The α-glucosidase inhibitory activity of the synthesised complexes A and B against the positive control acarbose display IC50 value at 490.32 and 223.01 µg/mL. In vitro antiproliferative and cytotoxic effects of complexes A and B are analysed on SK-MEL-28 and non-tumoral L6 cell lines by microscopic and MTT assay methods. The IC50 for complexes A and B on SK-MEL-28 cancerous cell line are found to be 27.444 and 40.721 µg/mL and for non-tumoral L6 cells are 25.869 and 38.425 µg/mL respectively. The apoptotic study suggests that the synthesized complexes show late apoptotic effect on SK-MEL-28 cancerous cells and early apoptotic effect on non-tumoral L6 cells. Hence the obtained results suggest that the biological activities of the synthesised complexes depend on the nature of the ligands present in the complexes.http://www.sciencedirect.com/science/article/pii/S2667022423002633Ru(II)-mixed ligand complexesAntimicrobial activityα-glucosidase inhibitory activitySK-MEL-28 cell lineApoptotic effect |
| spellingShingle | Santhiya S Arul Mary S Sheeba Daniel Synthesis, characterization and biological evaluation of novel ruthenium(II)-polypyridine mixed ligand complexes bearing 1,2,4- triazole-thiol moiety Chemical Physics Impact Ru(II)-mixed ligand complexes Antimicrobial activity α-glucosidase inhibitory activity SK-MEL-28 cell line Apoptotic effect |
| title | Synthesis, characterization and biological evaluation of novel ruthenium(II)-polypyridine mixed ligand complexes bearing 1,2,4- triazole-thiol moiety |
| title_full | Synthesis, characterization and biological evaluation of novel ruthenium(II)-polypyridine mixed ligand complexes bearing 1,2,4- triazole-thiol moiety |
| title_fullStr | Synthesis, characterization and biological evaluation of novel ruthenium(II)-polypyridine mixed ligand complexes bearing 1,2,4- triazole-thiol moiety |
| title_full_unstemmed | Synthesis, characterization and biological evaluation of novel ruthenium(II)-polypyridine mixed ligand complexes bearing 1,2,4- triazole-thiol moiety |
| title_short | Synthesis, characterization and biological evaluation of novel ruthenium(II)-polypyridine mixed ligand complexes bearing 1,2,4- triazole-thiol moiety |
| title_sort | synthesis characterization and biological evaluation of novel ruthenium ii polypyridine mixed ligand complexes bearing 1 2 4 triazole thiol moiety |
| topic | Ru(II)-mixed ligand complexes Antimicrobial activity α-glucosidase inhibitory activity SK-MEL-28 cell line Apoptotic effect |
| url | http://www.sciencedirect.com/science/article/pii/S2667022423002633 |
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