Comparative evaluation of the efficacy and safety of intra-articular administration of hyaluronic acid and glucocorticoids in the complex therapy of osteoarthritis
Improving the treatment of knee (KN) osteoarthritis (OA) remains an urgent problem.Objective: to compare the efficacy and tolerability of intra-articular (i/a) administration of long-acting glucocorticoids (GCs) and Armaviscon®Forte and Armaviscon®Platinum hyaluronates in patients with knee OA.Mater...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IMA-PRESS LLC
2023-02-01
|
| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/1391 |
| _version_ | 1797876661243346944 |
|---|---|
| author | L. K. Peshekhonova T. E. Kotelnikova D. V. Peshekhonov G. A. Kalashnik |
| author_facet | L. K. Peshekhonova T. E. Kotelnikova D. V. Peshekhonov G. A. Kalashnik |
| author_sort | L. K. Peshekhonova |
| collection | DOAJ |
| description | Improving the treatment of knee (KN) osteoarthritis (OA) remains an urgent problem.Objective: to compare the efficacy and tolerability of intra-articular (i/a) administration of long-acting glucocorticoids (GCs) and Armaviscon®Forte and Armaviscon®Platinum hyaluronates in patients with knee OA.Material and methods. From November 2019 to April 2022, we examined and treated 60 patients (26 men and 34 women, mean age 41.32±3.71 years) suffering from primary KN OA. Study participants were randomly divided into three groups of 20 patients each. In the 1st group, a longacting GCs in combination with a local anesthetic was administered once i/a into the KN, in the 2nd – Armaviscon®Forte 2.3%, and in the 3rd – Armaviscon®Platinum 3%.Patients were examined at baseline, on the 14th and 60th day after a single injection of the drug. The intensity of pain was assessed on a visual analog scale (VAS), the Lequesne index, the KOOS, WOMAC, and EQ-5D questionnaires were used. When studying tolerability, the number of adverse reactions (ARs) was taken into account.Results. By the end of the observation period in the study groups, there was a decrease in the severity of pain and an increase in functionality with positive dynamics of the Lequesne and WOMAC indices. Both hyaluronic acid drugs had a positive effect on the functional state of the joints according to KOOS, improved the quality of life according to EQ-5D. The need for non-steroidal anti-inflammatory drugs in patients of the 2nd and 3rd groups decreased down to their complete cancellation. No adverse events requiring discontinuation of therapy have been reported. The advantage of i/a administration of hyaluronates in comparison with long-acting GCs was shown.Conclusion. In real clinical practice, in patients with symptomatic OA, i/a administration of hyaluronates allows obtaining more favorable results than the use of long-acting HA. |
| first_indexed | 2024-04-10T02:05:16Z |
| format | Article |
| id | doaj.art-4dc08f40539742ad93aec00dd7c51390 |
| institution | Directory Open Access Journal |
| issn | 1996-7012 2310-158X |
| language | Russian |
| last_indexed | 2024-04-10T02:05:16Z |
| publishDate | 2023-02-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj.art-4dc08f40539742ad93aec00dd7c513902023-03-13T08:39:30ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2023-02-0117110.14412/1996-7012-2023-1-70-772553Comparative evaluation of the efficacy and safety of intra-articular administration of hyaluronic acid and glucocorticoids in the complex therapy of osteoarthritisL. K. Peshekhonova0T. E. Kotelnikova1D. V. Peshekhonov2G. A. Kalashnik3ФГОБУ ВО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава России; ЧУЗ «Клиническая больница «РЖД – Медицина» города Воронеж»ФГОБУ ВО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава России; ЧУЗ «Клиническая больница «РЖД – Медицина» города Воронеж»ЧУЗ «Клиническая больница «РЖД – Медицина» города Воронеж»ЧУЗ «Клиническая больница «РЖД – Медицина» города Воронеж»Improving the treatment of knee (KN) osteoarthritis (OA) remains an urgent problem.Objective: to compare the efficacy and tolerability of intra-articular (i/a) administration of long-acting glucocorticoids (GCs) and Armaviscon®Forte and Armaviscon®Platinum hyaluronates in patients with knee OA.Material and methods. From November 2019 to April 2022, we examined and treated 60 patients (26 men and 34 women, mean age 41.32±3.71 years) suffering from primary KN OA. Study participants were randomly divided into three groups of 20 patients each. In the 1st group, a longacting GCs in combination with a local anesthetic was administered once i/a into the KN, in the 2nd – Armaviscon®Forte 2.3%, and in the 3rd – Armaviscon®Platinum 3%.Patients were examined at baseline, on the 14th and 60th day after a single injection of the drug. The intensity of pain was assessed on a visual analog scale (VAS), the Lequesne index, the KOOS, WOMAC, and EQ-5D questionnaires were used. When studying tolerability, the number of adverse reactions (ARs) was taken into account.Results. By the end of the observation period in the study groups, there was a decrease in the severity of pain and an increase in functionality with positive dynamics of the Lequesne and WOMAC indices. Both hyaluronic acid drugs had a positive effect on the functional state of the joints according to KOOS, improved the quality of life according to EQ-5D. The need for non-steroidal anti-inflammatory drugs in patients of the 2nd and 3rd groups decreased down to their complete cancellation. No adverse events requiring discontinuation of therapy have been reported. The advantage of i/a administration of hyaluronates in comparison with long-acting GCs was shown.Conclusion. In real clinical practice, in patients with symptomatic OA, i/a administration of hyaluronates allows obtaining more favorable results than the use of long-acting HA.https://mrj.ima-press.net/mrj/article/view/1391остеоартритколенный суставгиалуроновая кислотаармависконглюкокортикоидынестероидные противовоспалительные препаратыэффективностьпереносимость |
| spellingShingle | L. K. Peshekhonova T. E. Kotelnikova D. V. Peshekhonov G. A. Kalashnik Comparative evaluation of the efficacy and safety of intra-articular administration of hyaluronic acid and glucocorticoids in the complex therapy of osteoarthritis Современная ревматология остеоартрит коленный сустав гиалуроновая кислота армавискон глюкокортикоиды нестероидные противовоспалительные препараты эффективность переносимость |
| title | Comparative evaluation of the efficacy and safety of intra-articular administration of hyaluronic acid and glucocorticoids in the complex therapy of osteoarthritis |
| title_full | Comparative evaluation of the efficacy and safety of intra-articular administration of hyaluronic acid and glucocorticoids in the complex therapy of osteoarthritis |
| title_fullStr | Comparative evaluation of the efficacy and safety of intra-articular administration of hyaluronic acid and glucocorticoids in the complex therapy of osteoarthritis |
| title_full_unstemmed | Comparative evaluation of the efficacy and safety of intra-articular administration of hyaluronic acid and glucocorticoids in the complex therapy of osteoarthritis |
| title_short | Comparative evaluation of the efficacy and safety of intra-articular administration of hyaluronic acid and glucocorticoids in the complex therapy of osteoarthritis |
| title_sort | comparative evaluation of the efficacy and safety of intra articular administration of hyaluronic acid and glucocorticoids in the complex therapy of osteoarthritis |
| topic | остеоартрит коленный сустав гиалуроновая кислота армавискон глюкокортикоиды нестероидные противовоспалительные препараты эффективность переносимость |
| url | https://mrj.ima-press.net/mrj/article/view/1391 |
| work_keys_str_mv | AT lkpeshekhonova comparativeevaluationoftheefficacyandsafetyofintraarticularadministrationofhyaluronicacidandglucocorticoidsinthecomplextherapyofosteoarthritis AT tekotelnikova comparativeevaluationoftheefficacyandsafetyofintraarticularadministrationofhyaluronicacidandglucocorticoidsinthecomplextherapyofosteoarthritis AT dvpeshekhonov comparativeevaluationoftheefficacyandsafetyofintraarticularadministrationofhyaluronicacidandglucocorticoidsinthecomplextherapyofosteoarthritis AT gakalashnik comparativeevaluationoftheefficacyandsafetyofintraarticularadministrationofhyaluronicacidandglucocorticoidsinthecomplextherapyofosteoarthritis |