RSV Replication, Transmission, and Disease Are Influenced by the RSV G Protein
It is important to understand the features affecting virus replication, fitness, and transmissibility as they contribute to the outcome of infection and affect disease intervention approaches. Respiratory syncytial virus (RSV) is a major contributor to respiratory disease, particularly in the infant...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/11/2396 |
| _version_ | 1827645276053045248 |
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| author | Harrison C. Bergeron Ralph A. Tripp |
| author_facet | Harrison C. Bergeron Ralph A. Tripp |
| author_sort | Harrison C. Bergeron |
| collection | DOAJ |
| description | It is important to understand the features affecting virus replication, fitness, and transmissibility as they contribute to the outcome of infection and affect disease intervention approaches. Respiratory syncytial virus (RSV) is a major contributor to respiratory disease, particularly in the infant and elderly populations. Although first described over 60 years ago, there are no approved vaccines and there are limited specific antiviral treatments due in part to our incomplete understanding of the features affecting RSV replication, immunity, and disease. RSV studies have typically focused on using continuous cell lines and conventional RSV strains to establish vaccine development and various antiviral countermeasures. This review outlines how the RSV G protein influences viral features, including replication, transmission, and disease, and how understanding the role of the G protein can improve the understanding of preclinical studies. |
| first_indexed | 2024-03-09T18:34:05Z |
| format | Article |
| id | doaj.art-4dc475527eca44d696c3ea737db79648 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T18:34:05Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-4dc475527eca44d696c3ea737db796482023-11-24T07:16:32ZengMDPI AGViruses1999-49152022-10-011411239610.3390/v14112396RSV Replication, Transmission, and Disease Are Influenced by the RSV G ProteinHarrison C. Bergeron0Ralph A. Tripp1Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30605, USADepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30605, USAIt is important to understand the features affecting virus replication, fitness, and transmissibility as they contribute to the outcome of infection and affect disease intervention approaches. Respiratory syncytial virus (RSV) is a major contributor to respiratory disease, particularly in the infant and elderly populations. Although first described over 60 years ago, there are no approved vaccines and there are limited specific antiviral treatments due in part to our incomplete understanding of the features affecting RSV replication, immunity, and disease. RSV studies have typically focused on using continuous cell lines and conventional RSV strains to establish vaccine development and various antiviral countermeasures. This review outlines how the RSV G protein influences viral features, including replication, transmission, and disease, and how understanding the role of the G protein can improve the understanding of preclinical studies.https://www.mdpi.com/1999-4915/14/11/2396RSVreplicationfitnessG proteinimmunityvaccines |
| spellingShingle | Harrison C. Bergeron Ralph A. Tripp RSV Replication, Transmission, and Disease Are Influenced by the RSV G Protein Viruses RSV replication fitness G protein immunity vaccines |
| title | RSV Replication, Transmission, and Disease Are Influenced by the RSV G Protein |
| title_full | RSV Replication, Transmission, and Disease Are Influenced by the RSV G Protein |
| title_fullStr | RSV Replication, Transmission, and Disease Are Influenced by the RSV G Protein |
| title_full_unstemmed | RSV Replication, Transmission, and Disease Are Influenced by the RSV G Protein |
| title_short | RSV Replication, Transmission, and Disease Are Influenced by the RSV G Protein |
| title_sort | rsv replication transmission and disease are influenced by the rsv g protein |
| topic | RSV replication fitness G protein immunity vaccines |
| url | https://www.mdpi.com/1999-4915/14/11/2396 |
| work_keys_str_mv | AT harrisoncbergeron rsvreplicationtransmissionanddiseaseareinfluencedbythersvgprotein AT ralphatripp rsvreplicationtransmissionanddiseaseareinfluencedbythersvgprotein |