MicroRNA-122 in human cancers: from mechanistic to clinical perspectives
Abstract MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with mRNA-coding genes. MiRNAs play vital roles in many biological functions, and abnormal miRNA expression has been linked to various illnesses, incl...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-023-02868-z |
| _version_ | 1827982631014236160 |
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| author | Mahboobeh Faramin Lashkarian Nasrin Hashemipour Negin Niaraki Shahrad Soghala Ali Moradi Sareh Sarhangi Mahsa Hatami Fatemehsadat Aghaei-Zarch Mina Khosravifar Alireza Mohammadzadeh Sajad Najafi Jamal Majidpoor Poopak Farnia Seyed Mohsen Aghaei-Zarch |
| author_facet | Mahboobeh Faramin Lashkarian Nasrin Hashemipour Negin Niaraki Shahrad Soghala Ali Moradi Sareh Sarhangi Mahsa Hatami Fatemehsadat Aghaei-Zarch Mina Khosravifar Alireza Mohammadzadeh Sajad Najafi Jamal Majidpoor Poopak Farnia Seyed Mohsen Aghaei-Zarch |
| author_sort | Mahboobeh Faramin Lashkarian |
| collection | DOAJ |
| description | Abstract MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with mRNA-coding genes. MiRNAs play vital roles in many biological functions, and abnormal miRNA expression has been linked to various illnesses, including cancer. Among the miRNAs, miR-122, miR-206, miR-21, miR-210, miR-223, and miR-424 have been extensively studied in various cancers. Although research in miRNAs has grown considerably over the last decade, much is yet to be discovered, especially regarding their role in cancer therapies. Several kinds of cancer have been linked to dysregulation and abnormal expression of miR-122, indicating that miR-122 may serve as a diagnostic and/or prognostic biomarker for human cancer. Consequently, in this review literature, miR-122 has been analyzed in numerous cancer types to sort out the function of cancer cells miR-122 and enhance patient response to standard therapy. |
| first_indexed | 2024-04-09T22:36:59Z |
| format | Article |
| id | doaj.art-4dc51b7927864e3f8e8ada76e96a18ef |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-04-09T22:36:59Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-4dc51b7927864e3f8e8ada76e96a18ef2023-03-22T12:26:41ZengBMCCancer Cell International1475-28672023-02-0123112510.1186/s12935-023-02868-zMicroRNA-122 in human cancers: from mechanistic to clinical perspectivesMahboobeh Faramin Lashkarian0Nasrin Hashemipour1Negin Niaraki2Shahrad Soghala3Ali Moradi4Sareh Sarhangi5Mahsa Hatami6Fatemehsadat Aghaei-Zarch7Mina Khosravifar8Alireza Mohammadzadeh9Sajad Najafi10Jamal Majidpoor11Poopak Farnia12Seyed Mohsen Aghaei-Zarch13Department of Molecular Genetics, Central Tehran Branch, Islamic Azad UniversityDepartment of Biology, School of Science, Yazd UniversityDepartment of Cell and Molecular Biology, School of Life Sciences and Biotechnology, Shahid Beheshti UniversityDepartment of Biology, Science and Research Branch, Islamic Azad UniversitySchool of Advanced Sciences and Technology, Tehran Medical Sciences Branch, Islamic Azad UniversityDepartment of Genetics, School of Advanced Sciences and Technology, Tehran Medical Sciences Branch, Islamic Azad UniversityDepartment of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical SciencesSchool of Medicine, Kerman University of Medical SciencesInstitute of Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of PennsylvaniaDepartment of Microbiology, School of Medicine, Infectious Diseases Research Center, Gonabad University of Medical SciencesDepartment of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical SciencesDepartment of Anatomy, Faculty of Medicine, Infectious Disease Research Center, Gonabad University of Medical SciencesMycobacteriology Research Centre, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical SciencesDepartment of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical SciencesAbstract MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with mRNA-coding genes. MiRNAs play vital roles in many biological functions, and abnormal miRNA expression has been linked to various illnesses, including cancer. Among the miRNAs, miR-122, miR-206, miR-21, miR-210, miR-223, and miR-424 have been extensively studied in various cancers. Although research in miRNAs has grown considerably over the last decade, much is yet to be discovered, especially regarding their role in cancer therapies. Several kinds of cancer have been linked to dysregulation and abnormal expression of miR-122, indicating that miR-122 may serve as a diagnostic and/or prognostic biomarker for human cancer. Consequently, in this review literature, miR-122 has been analyzed in numerous cancer types to sort out the function of cancer cells miR-122 and enhance patient response to standard therapy.https://doi.org/10.1186/s12935-023-02868-zCancermiR-122PathogenesisTherapyPrognosis |
| spellingShingle | Mahboobeh Faramin Lashkarian Nasrin Hashemipour Negin Niaraki Shahrad Soghala Ali Moradi Sareh Sarhangi Mahsa Hatami Fatemehsadat Aghaei-Zarch Mina Khosravifar Alireza Mohammadzadeh Sajad Najafi Jamal Majidpoor Poopak Farnia Seyed Mohsen Aghaei-Zarch MicroRNA-122 in human cancers: from mechanistic to clinical perspectives Cancer Cell International Cancer miR-122 Pathogenesis Therapy Prognosis |
| title | MicroRNA-122 in human cancers: from mechanistic to clinical perspectives |
| title_full | MicroRNA-122 in human cancers: from mechanistic to clinical perspectives |
| title_fullStr | MicroRNA-122 in human cancers: from mechanistic to clinical perspectives |
| title_full_unstemmed | MicroRNA-122 in human cancers: from mechanistic to clinical perspectives |
| title_short | MicroRNA-122 in human cancers: from mechanistic to clinical perspectives |
| title_sort | microrna 122 in human cancers from mechanistic to clinical perspectives |
| topic | Cancer miR-122 Pathogenesis Therapy Prognosis |
| url | https://doi.org/10.1186/s12935-023-02868-z |
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