Paraoxonase 1 (PON1) Q192R genotypes and their interaction with smoking strongly increase atherogenicity and the Framingham risk score

Paraoxonase 1 (PON1) Q192R genotypes and their interaction with smoking strongly increase atherogenicity and the Framingham risk score

ABSTRACT Objective Paraoxonase 1 (PON1) polymorphisms are associated with an increased susceptibility to cardiovascular disease. PON1 Q192R polymorphism (rs662) partially determine PON1 hydrolytic activity and protect against oxidation of LDL and HDL. This study aimed to delineate the association...

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Bibliographic Details
Main Authors: Andre de Souza-Nogueira, Alissana Ester Camargo, Felipe Assan Remondi, Monica Maria Bastos Paoliello, Rebecca J. Richter, Clement E. Furlong, Decio Sabbatini Barbosa, Michael Maes, Estefania Gastaldello Moreira
Format: Article
Language:English
Published: Brazilian Society of Endocrinology and Metabolism 2016-08-01
Series:Archives of Endocrinology and Metabolism
Subjects:
Atherogenic index
cardiovascular risk
Framingham score risk
lipid profile
paraoxonase 1
smoking
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000500426&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000500426&lng=en&tlng=en

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