Estrogen in Luteal Phase Support: Effects on IVF-ICSI Antagonist Protocol Pregnancy Results
Aim: This study aimed to investigate the effect of luteal phase support (LPS) with estradiol in addition to progesterone on pregnancy outcomes in patients who underwent ovulation induction with GnRH antagonist protocol in in vitro fertilization- intracytoplasmic sperm injection (IVF-ICSI). Materials...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Rabia Yılmaz
2022-11-01
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| Series: | Journal of Contemporary Medicine |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/2464352 |
| _version_ | 1797860748190285824 |
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| author | Hüseyin Görkemli Cemre Alan |
| author_facet | Hüseyin Görkemli Cemre Alan |
| author_sort | Hüseyin Görkemli |
| collection | DOAJ |
| description | Aim: This study aimed to investigate the effect of luteal phase support (LPS) with estradiol in addition to progesterone on pregnancy outcomes in patients who underwent ovulation induction with GnRH antagonist protocol in in vitro fertilization- intracytoplasmic sperm injection (IVF-ICSI).
Materials and Methods: This retrospective study was carried out at reproductive medicine center of Necmettin Erbakan University Meram Medical Faculty. The study enrolled 128 patients undergoing ICSI on an antagonist protocol for controlled ovarian hyperstimulation. Study group administered 7.8 mg transdermal estradiol (E2) daily in addition to progesterone for LPS (n=64). Control group administered only progesterone for LPS (n=64). All women received 200 mg progesterone 3x1 intravaginal daily and 50 mg progesterone intramuscular injection per two days for LPS. Blood samples were drawn 12 days after embryo transfer for β-hCG. If the result is negative, treatment was discontinued, if positive, estradiol was discontinued and progesterone support was continued until the 10th week of gestation. Pregnancy outcomes were the main endpoint.
Results: There was no difference between groups in terms of biochemical pregnancy, clinical pregnancy, abortus and ongoing pregnancy rates.
Conclusion: In our study, the use of estrogen for luteal phase support in GnRH antagonist protocol did not show any difference on pregnancy outcomes. |
| first_indexed | 2024-04-09T21:50:43Z |
| format | Article |
| id | doaj.art-4dc618bf9f6d49e5bf20b904337ec7b3 |
| institution | Directory Open Access Journal |
| issn | 2667-7180 |
| language | English |
| last_indexed | 2024-04-09T21:50:43Z |
| publishDate | 2022-11-01 |
| publisher | Rabia Yılmaz |
| record_format | Article |
| series | Journal of Contemporary Medicine |
| spelling | doaj.art-4dc618bf9f6d49e5bf20b904337ec7b32023-03-24T19:43:21ZengRabia YılmazJournal of Contemporary Medicine2667-71802022-11-0112697898310.16899/jcm.11254891809Estrogen in Luteal Phase Support: Effects on IVF-ICSI Antagonist Protocol Pregnancy ResultsHüseyin Görkemli0Cemre Alan1NECMETTIN ERBAKAN UNIVERSITY, MERAM SCHOOL OF MEDICINENECMETTIN ERBAKAN UNIVERSITY, MERAM SCHOOL OF MEDICINEAim: This study aimed to investigate the effect of luteal phase support (LPS) with estradiol in addition to progesterone on pregnancy outcomes in patients who underwent ovulation induction with GnRH antagonist protocol in in vitro fertilization- intracytoplasmic sperm injection (IVF-ICSI). Materials and Methods: This retrospective study was carried out at reproductive medicine center of Necmettin Erbakan University Meram Medical Faculty. The study enrolled 128 patients undergoing ICSI on an antagonist protocol for controlled ovarian hyperstimulation. Study group administered 7.8 mg transdermal estradiol (E2) daily in addition to progesterone for LPS (n=64). Control group administered only progesterone for LPS (n=64). All women received 200 mg progesterone 3x1 intravaginal daily and 50 mg progesterone intramuscular injection per two days for LPS. Blood samples were drawn 12 days after embryo transfer for β-hCG. If the result is negative, treatment was discontinued, if positive, estradiol was discontinued and progesterone support was continued until the 10th week of gestation. Pregnancy outcomes were the main endpoint. Results: There was no difference between groups in terms of biochemical pregnancy, clinical pregnancy, abortus and ongoing pregnancy rates. Conclusion: In our study, the use of estrogen for luteal phase support in GnRH antagonist protocol did not show any difference on pregnancy outcomes.https://dergipark.org.tr/tr/download/article-file/2464352luteal faz desteğiestradiolgnrh antagonisticsiluteal phase supportestradiolgnrh antagonisticsi |
| spellingShingle | Hüseyin Görkemli Cemre Alan Estrogen in Luteal Phase Support: Effects on IVF-ICSI Antagonist Protocol Pregnancy Results Journal of Contemporary Medicine luteal faz desteği estradiol gnrh antagonist icsi luteal phase support estradiol gnrh antagonist icsi |
| title | Estrogen in Luteal Phase Support: Effects on IVF-ICSI Antagonist Protocol Pregnancy Results |
| title_full | Estrogen in Luteal Phase Support: Effects on IVF-ICSI Antagonist Protocol Pregnancy Results |
| title_fullStr | Estrogen in Luteal Phase Support: Effects on IVF-ICSI Antagonist Protocol Pregnancy Results |
| title_full_unstemmed | Estrogen in Luteal Phase Support: Effects on IVF-ICSI Antagonist Protocol Pregnancy Results |
| title_short | Estrogen in Luteal Phase Support: Effects on IVF-ICSI Antagonist Protocol Pregnancy Results |
| title_sort | estrogen in luteal phase support effects on ivf icsi antagonist protocol pregnancy results |
| topic | luteal faz desteği estradiol gnrh antagonist icsi luteal phase support estradiol gnrh antagonist icsi |
| url | https://dergipark.org.tr/tr/download/article-file/2464352 |
| work_keys_str_mv | AT huseyingorkemli estrogeninlutealphasesupporteffectsonivficsiantagonistprotocolpregnancyresults AT cemrealan estrogeninlutealphasesupporteffectsonivficsiantagonistprotocolpregnancyresults |