Prediction of Tumor Development and Urine-Based Liquid Biopsy for Molecule-Targeted Therapy of Gliomas
The timing of the acquisition of tumor-specific gene mutations and the systems by which these gene mutations are acquired during tumorigenesis were clarified. Advances in our understanding of tumorigenesis are being made every day, and therapies targeting fundamental genetic alterations have great p...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Genes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4425/14/6/1201 |
| _version_ | 1797594648481366016 |
|---|---|
| author | Michihiro Kurimoto Yumi Rockenbach Akira Kato Atsushi Natsume |
| author_facet | Michihiro Kurimoto Yumi Rockenbach Akira Kato Atsushi Natsume |
| author_sort | Michihiro Kurimoto |
| collection | DOAJ |
| description | The timing of the acquisition of tumor-specific gene mutations and the systems by which these gene mutations are acquired during tumorigenesis were clarified. Advances in our understanding of tumorigenesis are being made every day, and therapies targeting fundamental genetic alterations have great potential for cancer treatment. Moreover, our research team successfully estimated tumor progression using mathematical modeling and attempted early diagnosis of brain tumors. We developed a nanodevice that enables urinary genetic diagnosis in a simple and noninvasive manner. Mainly on the basis of our research and experience, this review article presents novel therapies being developed for central nervous system cancers and six molecules, which upon mutation cause tumorigenesis and tumor progression. Further understanding of the genetic characteristics of brain tumors will lead to the development of precise drugs and improve individual treatment outcomes. |
| first_indexed | 2024-03-11T02:25:17Z |
| format | Article |
| id | doaj.art-4dc6ed2908f94aacaae378334c1e82b4 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-11T02:25:17Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-4dc6ed2908f94aacaae378334c1e82b42023-11-18T10:34:12ZengMDPI AGGenes2073-44252023-05-01146120110.3390/genes14061201Prediction of Tumor Development and Urine-Based Liquid Biopsy for Molecule-Targeted Therapy of GliomasMichihiro Kurimoto0Yumi Rockenbach1Akira Kato2Atsushi Natsume3Department of Neurosurgery, Aichi Children’s Health and Medical Center, Obu 464-8710, JapanInstitute of Innovation for Future Society, Nagoya University, Nagoya 464-8601, JapanInstitute of Innovation for Future Society, Nagoya University, Nagoya 464-8601, JapanInstitute of Innovation for Future Society, Nagoya University, Nagoya 464-8601, JapanThe timing of the acquisition of tumor-specific gene mutations and the systems by which these gene mutations are acquired during tumorigenesis were clarified. Advances in our understanding of tumorigenesis are being made every day, and therapies targeting fundamental genetic alterations have great potential for cancer treatment. Moreover, our research team successfully estimated tumor progression using mathematical modeling and attempted early diagnosis of brain tumors. We developed a nanodevice that enables urinary genetic diagnosis in a simple and noninvasive manner. Mainly on the basis of our research and experience, this review article presents novel therapies being developed for central nervous system cancers and six molecules, which upon mutation cause tumorigenesis and tumor progression. Further understanding of the genetic characteristics of brain tumors will lead to the development of precise drugs and improve individual treatment outcomes.https://www.mdpi.com/2073-4425/14/6/1201brain tumorgliomagene mutationmathematical modelisocitrate dehydrogenasemicroRNA |
| spellingShingle | Michihiro Kurimoto Yumi Rockenbach Akira Kato Atsushi Natsume Prediction of Tumor Development and Urine-Based Liquid Biopsy for Molecule-Targeted Therapy of Gliomas Genes brain tumor glioma gene mutation mathematical model isocitrate dehydrogenase microRNA |
| title | Prediction of Tumor Development and Urine-Based Liquid Biopsy for Molecule-Targeted Therapy of Gliomas |
| title_full | Prediction of Tumor Development and Urine-Based Liquid Biopsy for Molecule-Targeted Therapy of Gliomas |
| title_fullStr | Prediction of Tumor Development and Urine-Based Liquid Biopsy for Molecule-Targeted Therapy of Gliomas |
| title_full_unstemmed | Prediction of Tumor Development and Urine-Based Liquid Biopsy for Molecule-Targeted Therapy of Gliomas |
| title_short | Prediction of Tumor Development and Urine-Based Liquid Biopsy for Molecule-Targeted Therapy of Gliomas |
| title_sort | prediction of tumor development and urine based liquid biopsy for molecule targeted therapy of gliomas |
| topic | brain tumor glioma gene mutation mathematical model isocitrate dehydrogenase microRNA |
| url | https://www.mdpi.com/2073-4425/14/6/1201 |
| work_keys_str_mv | AT michihirokurimoto predictionoftumordevelopmentandurinebasedliquidbiopsyformoleculetargetedtherapyofgliomas AT yumirockenbach predictionoftumordevelopmentandurinebasedliquidbiopsyformoleculetargetedtherapyofgliomas AT akirakato predictionoftumordevelopmentandurinebasedliquidbiopsyformoleculetargetedtherapyofgliomas AT atsushinatsume predictionoftumordevelopmentandurinebasedliquidbiopsyformoleculetargetedtherapyofgliomas |