Emotional and behavioral features associated with subclinical hypothyroidism in children and adolescents with Down syndrome
BackgroundSubclinical hypothyroidism (SH) is particularly frequent in individuals with Down syndrome (DS). Despite the amount of evidence suggesting SH is associated with psychopathological symptoms and sleep problems in general population, poor is known about the emotional and behavioral features a...
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1294908/full |
| _version_ | 1797322690373091328 |
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| author | Elisa Fucà Floriana Costanzo Paolo Galassi Laura Celestini Alberto Villani Diletta Valentini Stefano Vicari Stefano Vicari |
| author_facet | Elisa Fucà Floriana Costanzo Paolo Galassi Laura Celestini Alberto Villani Diletta Valentini Stefano Vicari Stefano Vicari |
| author_sort | Elisa Fucà |
| collection | DOAJ |
| description | BackgroundSubclinical hypothyroidism (SH) is particularly frequent in individuals with Down syndrome (DS). Despite the amount of evidence suggesting SH is associated with psychopathological symptoms and sleep problems in general population, poor is known about the emotional and behavioral features associated with SH in children with DS.ObjectiveThe first aim of the current study was to investigate differences in emotional and behavioral profiles between a group of children with DS exhibiting co-occurring SH and a group of age and BMI-matched children with DS without co-occurring SH. The second aim of the present study was to investigate differences in sleep disturbances between these groups.MethodsWe included in this retrospective study 98 participants with DS aged 3–18 years with the aim to explore differences in emotional/behavioral problems as well as in sleep difficulties between children with DS with or without co-occurring SH.ResultsParticipants with co-occurring SH exhibited significantly higher scores at several scales of the Conners’ Parent Rating Scales Long Version – Revised. However, they did not exhibit more sleep problems than control group.ConclusionThese results provide specific indications for psychological and neuropsychiatric evaluation of children with DS with suspected or diagnosed SH, highlighting the importance of a multidisciplinary approach in clinical care for children and adolescents with DS. |
| first_indexed | 2024-03-08T05:17:55Z |
| format | Article |
| id | doaj.art-4dc7704bac7c423680ebb64c71209750 |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-03-08T05:17:55Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-4dc7704bac7c423680ebb64c712097502024-02-06T14:48:32ZengFrontiers Media S.A.Frontiers in Psychology1664-10782024-02-011410.3389/fpsyg.2023.12949081294908Emotional and behavioral features associated with subclinical hypothyroidism in children and adolescents with Down syndromeElisa Fucà0Floriana Costanzo1Paolo Galassi2Laura Celestini3Alberto Villani4Diletta Valentini5Stefano Vicari6Stefano Vicari7Child and Adolescent Neuropsychiatry Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, ItalyChild and Adolescent Neuropsychiatry Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, ItalyChild and Adolescent Neuropsychiatry Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, ItalyPediatric Unit, Pediatric Emergency Department, Bambino Gesù Children's Hospital, IRCCS, Rome, ItalyPediatric Unit, Pediatric Emergency Department, Bambino Gesù Children's Hospital, IRCCS, Rome, ItalyPediatric Unit, Pediatric Emergency Department, Bambino Gesù Children's Hospital, IRCCS, Rome, ItalyChild and Adolescent Neuropsychiatry Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, ItalyDepartment of Life Science and Public Health, Catholic University of the Sacred Heart, Rome, ItalyBackgroundSubclinical hypothyroidism (SH) is particularly frequent in individuals with Down syndrome (DS). Despite the amount of evidence suggesting SH is associated with psychopathological symptoms and sleep problems in general population, poor is known about the emotional and behavioral features associated with SH in children with DS.ObjectiveThe first aim of the current study was to investigate differences in emotional and behavioral profiles between a group of children with DS exhibiting co-occurring SH and a group of age and BMI-matched children with DS without co-occurring SH. The second aim of the present study was to investigate differences in sleep disturbances between these groups.MethodsWe included in this retrospective study 98 participants with DS aged 3–18 years with the aim to explore differences in emotional/behavioral problems as well as in sleep difficulties between children with DS with or without co-occurring SH.ResultsParticipants with co-occurring SH exhibited significantly higher scores at several scales of the Conners’ Parent Rating Scales Long Version – Revised. However, they did not exhibit more sleep problems than control group.ConclusionThese results provide specific indications for psychological and neuropsychiatric evaluation of children with DS with suspected or diagnosed SH, highlighting the importance of a multidisciplinary approach in clinical care for children and adolescents with DS.https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1294908/fullthyroid dysfunctiontrisomy 21CBCLparasomniassleep–wake transition disorderspsychopathology |
| spellingShingle | Elisa Fucà Floriana Costanzo Paolo Galassi Laura Celestini Alberto Villani Diletta Valentini Stefano Vicari Stefano Vicari Emotional and behavioral features associated with subclinical hypothyroidism in children and adolescents with Down syndrome Frontiers in Psychology thyroid dysfunction trisomy 21 CBCL parasomnias sleep–wake transition disorders psychopathology |
| title | Emotional and behavioral features associated with subclinical hypothyroidism in children and adolescents with Down syndrome |
| title_full | Emotional and behavioral features associated with subclinical hypothyroidism in children and adolescents with Down syndrome |
| title_fullStr | Emotional and behavioral features associated with subclinical hypothyroidism in children and adolescents with Down syndrome |
| title_full_unstemmed | Emotional and behavioral features associated with subclinical hypothyroidism in children and adolescents with Down syndrome |
| title_short | Emotional and behavioral features associated with subclinical hypothyroidism in children and adolescents with Down syndrome |
| title_sort | emotional and behavioral features associated with subclinical hypothyroidism in children and adolescents with down syndrome |
| topic | thyroid dysfunction trisomy 21 CBCL parasomnias sleep–wake transition disorders psychopathology |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1294908/full |
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