Koninginins X-Z, Three New Polyketides from <i>Trichoderma koningiopsis</i> SC-5

Koninginins X-Z, Three New Polyketides from <i>Trichoderma koningiopsis</i> SC-5

Koninginins X-Z (<b>1</b>–<b>3</b>), three novel polyketides, were isolated from the solid fermentation of the endophytic fungus <i>Trichoderma koningiopsis</i> SC-5. Their structures, including the absolute configurations, were comprehensively characterized by a...

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Bibliographic Details
Main Authors: Weiwei Peng, Jianbing Tan, Zihuan Sang, Yuantao Huang, Li Xu, Yuting Zheng, Siyu Qin, Haibo Tan, Zhenxing Zou
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Molecules
Subjects:
<i>Trichoderma koningiopsis</i>
endophytic fungi
secondary metabolites
polyketide
antifungal activity
Online Access:https://www.mdpi.com/1420-3049/28/23/7848
Description
Summary:Koninginins X-Z (<b>1</b>–<b>3</b>), three novel polyketides, were isolated from the solid fermentation of the endophytic fungus <i>Trichoderma koningiopsis</i> SC-5. Their structures, including the absolute configurations, were comprehensively characterized by a combination of NMR spectroscopic methods, HRESIMS, <sup>13</sup>C NMR, DFT GIAO <sup>13</sup>C NMR, and electronic circular dichroism calculations as well as single crystal X-ray diffraction. In addition, all the compounds were evaluated for antifungal activity against <i>Candida albicans</i>.
ISSN:1420-3049

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