The Role of PET Imaging in the Differential Diagnosis between Radiation Necrosis and Recurrent Disease in Irradiated Adult-Type Diffuse Gliomas: A Systematic Review
Adult-type diffuse gliomas are treated with a multimodality treatment approach that includes radiotherapy both in the primary setting, and in the case of progressive or recurrent disease. Radiation necrosis represents a major complication of radiotherapy. Recurrent disease and treatment-related chan...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/2/364 |
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| author | Gaia Ninatti Cristiano Pini Fabrizia Gelardi Martina Sollini Arturo Chiti |
| author_facet | Gaia Ninatti Cristiano Pini Fabrizia Gelardi Martina Sollini Arturo Chiti |
| author_sort | Gaia Ninatti |
| collection | DOAJ |
| description | Adult-type diffuse gliomas are treated with a multimodality treatment approach that includes radiotherapy both in the primary setting, and in the case of progressive or recurrent disease. Radiation necrosis represents a major complication of radiotherapy. Recurrent disease and treatment-related changes are often indistinguishable using conventional imaging methods. The present systematic review aims at assessing the diagnostic role of PET imaging using different radiopharmaceuticals in differentiating radiation necrosis and disease relapse in irradiated adult-type diffuse gliomas. We conducted a comprehensive literature search using the PubMed/MEDLINE and EMBASE databases for original research studies of interest. In total, 436 articles were assessed for eligibility. Ten original papers, published between 2014 and 2022, were selected. Four articles focused on [<sup>18</sup>F]FDG, seven on amino acid tracers ([<sup>18</sup>F]FET <i>n</i> = 3 and [<sup>11</sup>C]MET <i>n</i> = 4), one on [<sup>11</sup>C]CHO, and one on [<sup>68</sup>Ga]Ga-PSMA. Visual assessment, semi-quantitative methods, and radiomics were applied for image analysis. Furthermore, 2/10 papers were comparative studies investigating different radiopharmaceuticals. The present review, the first one on the topic in light of the new 2021 CNS WHO classification, highlighted the usefulness of PET imaging in distinguishing radiation necrosis and tumour recurrence, but revealed high heterogeneity among studies. |
| first_indexed | 2024-03-09T13:18:20Z |
| format | Article |
| id | doaj.art-4dc8956f988741c09c14f7f8720b2d66 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T13:18:20Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4dc8956f988741c09c14f7f8720b2d662023-11-30T21:32:50ZengMDPI AGCancers2072-66942023-01-0115236410.3390/cancers15020364The Role of PET Imaging in the Differential Diagnosis between Radiation Necrosis and Recurrent Disease in Irradiated Adult-Type Diffuse Gliomas: A Systematic ReviewGaia Ninatti0Cristiano Pini1Fabrizia Gelardi2Martina Sollini3Arturo Chiti4Residency Program in Nuclear Medicine, School of Medicine and Surgery, University of Milano Bicocca, 20900 Monza, ItalyDepartment of Biomedical Sciences, Humanitas University, Via R. Levi Montalcini 4, 20090 Pieve Emanuele, ItalyDepartment of Biomedical Sciences, Humanitas University, Via R. Levi Montalcini 4, 20090 Pieve Emanuele, ItalyDepartment of Biomedical Sciences, Humanitas University, Via R. Levi Montalcini 4, 20090 Pieve Emanuele, ItalyDepartment of Biomedical Sciences, Humanitas University, Via R. Levi Montalcini 4, 20090 Pieve Emanuele, ItalyAdult-type diffuse gliomas are treated with a multimodality treatment approach that includes radiotherapy both in the primary setting, and in the case of progressive or recurrent disease. Radiation necrosis represents a major complication of radiotherapy. Recurrent disease and treatment-related changes are often indistinguishable using conventional imaging methods. The present systematic review aims at assessing the diagnostic role of PET imaging using different radiopharmaceuticals in differentiating radiation necrosis and disease relapse in irradiated adult-type diffuse gliomas. We conducted a comprehensive literature search using the PubMed/MEDLINE and EMBASE databases for original research studies of interest. In total, 436 articles were assessed for eligibility. Ten original papers, published between 2014 and 2022, were selected. Four articles focused on [<sup>18</sup>F]FDG, seven on amino acid tracers ([<sup>18</sup>F]FET <i>n</i> = 3 and [<sup>11</sup>C]MET <i>n</i> = 4), one on [<sup>11</sup>C]CHO, and one on [<sup>68</sup>Ga]Ga-PSMA. Visual assessment, semi-quantitative methods, and radiomics were applied for image analysis. Furthermore, 2/10 papers were comparative studies investigating different radiopharmaceuticals. The present review, the first one on the topic in light of the new 2021 CNS WHO classification, highlighted the usefulness of PET imaging in distinguishing radiation necrosis and tumour recurrence, but revealed high heterogeneity among studies.https://www.mdpi.com/2072-6694/15/2/364adult-type diffuse gliomasprimary brain tumoursPET |
| spellingShingle | Gaia Ninatti Cristiano Pini Fabrizia Gelardi Martina Sollini Arturo Chiti The Role of PET Imaging in the Differential Diagnosis between Radiation Necrosis and Recurrent Disease in Irradiated Adult-Type Diffuse Gliomas: A Systematic Review Cancers adult-type diffuse gliomas primary brain tumours PET |
| title | The Role of PET Imaging in the Differential Diagnosis between Radiation Necrosis and Recurrent Disease in Irradiated Adult-Type Diffuse Gliomas: A Systematic Review |
| title_full | The Role of PET Imaging in the Differential Diagnosis between Radiation Necrosis and Recurrent Disease in Irradiated Adult-Type Diffuse Gliomas: A Systematic Review |
| title_fullStr | The Role of PET Imaging in the Differential Diagnosis between Radiation Necrosis and Recurrent Disease in Irradiated Adult-Type Diffuse Gliomas: A Systematic Review |
| title_full_unstemmed | The Role of PET Imaging in the Differential Diagnosis between Radiation Necrosis and Recurrent Disease in Irradiated Adult-Type Diffuse Gliomas: A Systematic Review |
| title_short | The Role of PET Imaging in the Differential Diagnosis between Radiation Necrosis and Recurrent Disease in Irradiated Adult-Type Diffuse Gliomas: A Systematic Review |
| title_sort | role of pet imaging in the differential diagnosis between radiation necrosis and recurrent disease in irradiated adult type diffuse gliomas a systematic review |
| topic | adult-type diffuse gliomas primary brain tumours PET |
| url | https://www.mdpi.com/2072-6694/15/2/364 |
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