Psychological impact of motor impairment in tow forms of congenital muscular dystrophy
Introduction Congenital muscular dystrophies (CMDs) represent a heterogeneous group of early-onset muscle disorders presenting primarily with hypotonia and delayed motor development. Several genes are known to be responsible for CMDs, including the LAMA2 gene, involved in merosin-deficient type 1A...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2023-03-01
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| Series: | European Psychiatry |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933823015390/type/journal_article |
| _version_ | 1797615985304272896 |
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| author | I. Boujelbene M. Chaabane M. Guirat D. Ben Touhemi N. Gharbi M. Yousr H. Kamoun I. Ben Ayed |
| author_facet | I. Boujelbene M. Chaabane M. Guirat D. Ben Touhemi N. Gharbi M. Yousr H. Kamoun I. Ben Ayed |
| author_sort | I. Boujelbene |
| collection | DOAJ |
| description |
Introduction
Congenital muscular dystrophies (CMDs) represent a heterogeneous group of early-onset muscle disorders presenting primarily with hypotonia and delayed motor development. Several genes are known to be responsible for CMDs, including the LAMA2 gene, involved in merosin-deficient type 1A (MDC1A), and the FKRP gene involved in muscular dystrophy-dystroglycanopathy type B5 (MDDGB5). These two forms of CMD are autosomal recessive and are each characterized by the presence of a mutation with a founder effect in South Tunisia. Cognitive development associated with the founder mutation in the LAMA2 gene (c.8007delT) is often conserved, whereas in the founder mutation of the FKRP gene (c.1364 C>A), motor impairment is associated with intellectual disability (ID).
Objectives
To compare the psychological impact of motor impairment in children presenting these two forms of CMD and their families.
Methods
The study consisted of a survey of parents of children with a confirmed diagnosis of MDC1A (5 from 3 unrelated families) or MDDGB5 (3 from 3 unrelated families). The correspondent founder mutation was already identified in the homozygous state by targeted sequencing. Participants’ parents completed the Parent Strengths and Difficulties Questionnaire (SDQ), a behavioral screening tool designed for children aged from 2 to 17 years. The SDQ assesses emotional symptoms, behavior problems, hyperactivity, and peer relationships; The SDQ Impact Supplement assesses the impact of all these children’s difficulties on their families.
Results
The average age of the children was 4.95±3.92 with two children who were not assessable by the SDQ (age< 2 years). Unlike children with MDC1A, ID has been reported in all children with MDDGB5. The mean SDQ total score for children with MDC1A was 11, whereas the mean score for children with MDDGB5 was 14.875, reflecting greater difficulty for children with MDDGB5. The family impact score was higher in families with children with MDDGB5 than in children with MDC1A (10,5 vs 7), which may be due to the burden of management of the ID associated with the motor impairment. The more pronounced difficulties associated with MDDGB5 are likely to be related to the associated ID. Whereas in MDC1A, the difficulties observed are related to the direct impact of the motor impairment. The presence of cognitive disorders associated with a motor deficit aggravates behavioral adaptation and makes the management of these children more difficult.
Conclusions
In the absence of a comparable study in the literature, the present is conducting future studies on the behavioral profile of children with CMD to obtain a better understanding of their difficulties in everyday life and to develop interventions adapted to their families
Disclosure of Interest
None Declared |
| first_indexed | 2024-03-11T07:34:48Z |
| format | Article |
| id | doaj.art-4dc9552400a34c94880e2e6edf24e7f3 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:34:48Z |
| publishDate | 2023-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-4dc9552400a34c94880e2e6edf24e7f32023-11-17T05:10:15ZengCambridge University PressEuropean Psychiatry0924-93381778-35852023-03-0166S733S73310.1192/j.eurpsy.2023.1539Psychological impact of motor impairment in tow forms of congenital muscular dystrophyI. Boujelbene0M. Chaabane1M. Guirat2D. Ben Touhemi3N. Gharbi4M. Yousr5H. Kamoun6I. Ben Ayed7Department of Medical GeneticDepartment of Medical Genetic Department of Child Psychiatry, Hedi Chaker Hospital, Sfax, TunisiaDepartment of Medical GeneticDepartment of Child Psychiatry, Hedi Chaker Hospital, Sfax, TunisiaDepartment of Medical GeneticDepartment of Child Psychiatry, Hedi Chaker Hospital, Sfax, TunisiaDepartment of Medical GeneticDepartment of Medical Genetic Introduction Congenital muscular dystrophies (CMDs) represent a heterogeneous group of early-onset muscle disorders presenting primarily with hypotonia and delayed motor development. Several genes are known to be responsible for CMDs, including the LAMA2 gene, involved in merosin-deficient type 1A (MDC1A), and the FKRP gene involved in muscular dystrophy-dystroglycanopathy type B5 (MDDGB5). These two forms of CMD are autosomal recessive and are each characterized by the presence of a mutation with a founder effect in South Tunisia. Cognitive development associated with the founder mutation in the LAMA2 gene (c.8007delT) is often conserved, whereas in the founder mutation of the FKRP gene (c.1364 C>A), motor impairment is associated with intellectual disability (ID). Objectives To compare the psychological impact of motor impairment in children presenting these two forms of CMD and their families. Methods The study consisted of a survey of parents of children with a confirmed diagnosis of MDC1A (5 from 3 unrelated families) or MDDGB5 (3 from 3 unrelated families). The correspondent founder mutation was already identified in the homozygous state by targeted sequencing. Participants’ parents completed the Parent Strengths and Difficulties Questionnaire (SDQ), a behavioral screening tool designed for children aged from 2 to 17 years. The SDQ assesses emotional symptoms, behavior problems, hyperactivity, and peer relationships; The SDQ Impact Supplement assesses the impact of all these children’s difficulties on their families. Results The average age of the children was 4.95±3.92 with two children who were not assessable by the SDQ (age< 2 years). Unlike children with MDC1A, ID has been reported in all children with MDDGB5. The mean SDQ total score for children with MDC1A was 11, whereas the mean score for children with MDDGB5 was 14.875, reflecting greater difficulty for children with MDDGB5. The family impact score was higher in families with children with MDDGB5 than in children with MDC1A (10,5 vs 7), which may be due to the burden of management of the ID associated with the motor impairment. The more pronounced difficulties associated with MDDGB5 are likely to be related to the associated ID. Whereas in MDC1A, the difficulties observed are related to the direct impact of the motor impairment. The presence of cognitive disorders associated with a motor deficit aggravates behavioral adaptation and makes the management of these children more difficult. Conclusions In the absence of a comparable study in the literature, the present is conducting future studies on the behavioral profile of children with CMD to obtain a better understanding of their difficulties in everyday life and to develop interventions adapted to their families Disclosure of Interest None Declaredhttps://www.cambridge.org/core/product/identifier/S0924933823015390/type/journal_article |
| spellingShingle | I. Boujelbene M. Chaabane M. Guirat D. Ben Touhemi N. Gharbi M. Yousr H. Kamoun I. Ben Ayed Psychological impact of motor impairment in tow forms of congenital muscular dystrophy European Psychiatry |
| title | Psychological impact of motor impairment in tow forms of congenital muscular dystrophy |
| title_full | Psychological impact of motor impairment in tow forms of congenital muscular dystrophy |
| title_fullStr | Psychological impact of motor impairment in tow forms of congenital muscular dystrophy |
| title_full_unstemmed | Psychological impact of motor impairment in tow forms of congenital muscular dystrophy |
| title_short | Psychological impact of motor impairment in tow forms of congenital muscular dystrophy |
| title_sort | psychological impact of motor impairment in tow forms of congenital muscular dystrophy |
| url | https://www.cambridge.org/core/product/identifier/S0924933823015390/type/journal_article |
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