Manganese-driven CoQ deficiency
Across phylae, excess manganese disrupts energy metabolism by unclear mechanisms. Here, Diessl et al. report that failure of mitochondrial bioenergetics upon manganese overload is due to mismetallation of a diiron enzyme crucial for CoQ biosynthesis
Bibliographic Details
| Main Authors: |
Jutta Diessl,
Jens Berndtsson,
Filomena Broeskamp,
Lukas Habernig,
Verena Kohler,
Carmela Vazquez-Calvo,
Arpita Nandy,
Carlotta Peselj,
Sofia Drobysheva,
Ludovic Pelosi,
F.-Nora Vögtle,
Fabien Pierrel,
Martin Ott,
Sabrina Büttner |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-33641-x
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