Manganese-driven CoQ deficiency
Across phylae, excess manganese disrupts energy metabolism by unclear mechanisms. Here, Diessl et al. report that failure of mitochondrial bioenergetics upon manganese overload is due to mismetallation of a diiron enzyme crucial for CoQ biosynthesis
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33641-x |
| _version_ | 1811238841980289024 |
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| author | Jutta Diessl Jens Berndtsson Filomena Broeskamp Lukas Habernig Verena Kohler Carmela Vazquez-Calvo Arpita Nandy Carlotta Peselj Sofia Drobysheva Ludovic Pelosi F.-Nora Vögtle Fabien Pierrel Martin Ott Sabrina Büttner |
| author_facet | Jutta Diessl Jens Berndtsson Filomena Broeskamp Lukas Habernig Verena Kohler Carmela Vazquez-Calvo Arpita Nandy Carlotta Peselj Sofia Drobysheva Ludovic Pelosi F.-Nora Vögtle Fabien Pierrel Martin Ott Sabrina Büttner |
| author_sort | Jutta Diessl |
| collection | DOAJ |
| description | Across phylae, excess manganese disrupts energy metabolism by unclear mechanisms. Here, Diessl et al. report that failure of mitochondrial bioenergetics upon manganese overload is due to mismetallation of a diiron enzyme crucial for CoQ biosynthesis |
| first_indexed | 2024-04-12T12:49:29Z |
| format | Article |
| id | doaj.art-4dc9625ee56c416c8681a2d756ae7db0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T12:49:29Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4dc9625ee56c416c8681a2d756ae7db02022-12-22T03:32:31ZengNature PortfolioNature Communications2041-17232022-10-0113111410.1038/s41467-022-33641-xManganese-driven CoQ deficiencyJutta Diessl0Jens Berndtsson1Filomena Broeskamp2Lukas Habernig3Verena Kohler4Carmela Vazquez-Calvo5Arpita Nandy6Carlotta Peselj7Sofia Drobysheva8Ludovic Pelosi9F.-Nora Vögtle10Fabien Pierrel11Martin Ott12Sabrina Büttner13Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityDepartment of Biochemistry and Biophysics, Stockholm UniversityDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityInstitute of Biochemistry and Molecular Biology, ZBMZ, University of FreiburgDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityUniv. Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMCInstitute of Biochemistry and Molecular Biology, ZBMZ, University of FreiburgUniv. Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMCDepartment of Biochemistry and Biophysics, Stockholm UniversityDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityAcross phylae, excess manganese disrupts energy metabolism by unclear mechanisms. Here, Diessl et al. report that failure of mitochondrial bioenergetics upon manganese overload is due to mismetallation of a diiron enzyme crucial for CoQ biosynthesishttps://doi.org/10.1038/s41467-022-33641-x |
| spellingShingle | Jutta Diessl Jens Berndtsson Filomena Broeskamp Lukas Habernig Verena Kohler Carmela Vazquez-Calvo Arpita Nandy Carlotta Peselj Sofia Drobysheva Ludovic Pelosi F.-Nora Vögtle Fabien Pierrel Martin Ott Sabrina Büttner Manganese-driven CoQ deficiency Nature Communications |
| title | Manganese-driven CoQ deficiency |
| title_full | Manganese-driven CoQ deficiency |
| title_fullStr | Manganese-driven CoQ deficiency |
| title_full_unstemmed | Manganese-driven CoQ deficiency |
| title_short | Manganese-driven CoQ deficiency |
| title_sort | manganese driven coq deficiency |
| url | https://doi.org/10.1038/s41467-022-33641-x |
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