Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy
Background: Dozens of paraneoplastic syndromes affect the visual system ranging from conjunctival pemphigoid to encephalopathy of the occipital cortex. The most profiled ocular syndromes are bilateral diffuse uveal melanocytic proliferation (BDUMP) and the autoimmune retinopathies. Purpose: To revie...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-12-01
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| Series: | Cancer Control |
| Online Access: | https://doi.org/10.1177/10732748221144458 |
| _version_ | 1797838700103598080 |
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| author | Thomas A. Weppelmann MD, PhD, MPH Sabrina Khalil MD Nabeel Zafrullah MD Sabah Amir MD, MBA Curtis E. Margo MD, MPH |
| author_facet | Thomas A. Weppelmann MD, PhD, MPH Sabrina Khalil MD Nabeel Zafrullah MD Sabah Amir MD, MBA Curtis E. Margo MD, MPH |
| author_sort | Thomas A. Weppelmann MD, PhD, MPH |
| collection | DOAJ |
| description | Background: Dozens of paraneoplastic syndromes affect the visual system ranging from conjunctival pemphigoid to encephalopathy of the occipital cortex. The most profiled ocular syndromes are bilateral diffuse uveal melanocytic proliferation (BDUMP) and the autoimmune retinopathies. Purpose: To review the critical features of these 2 entities then concentrate on advancements in treatment made within the last 10 years. Study Design: Literature review with structured data abstraction. Results: Major insights into pathogenesis have been wanting. Plasmapheresis appears to improve vision in a substantial proportion of patients with BDUMP. The number of clinical variables that influence visual outcome in paraneoplastic retinopathies combined with the variety of local and systemic treatment options makes interpretation of clinical effectiveness difficult. Conclusions: The rarity of these disorders makes randomized clinical trials unlikely. It may be time for a clinical professional organization to use a modified Delphi method to establish a consensus algorithm for the diagnosis and management of retinal paraneoplastic syndromes to augment clinical communications and clinical trials. |
| first_indexed | 2024-04-09T15:45:06Z |
| format | Article |
| id | doaj.art-4dcb6373b30d464ba0d35517bed8515b |
| institution | Directory Open Access Journal |
| issn | 1526-2359 |
| language | English |
| last_indexed | 2024-04-09T15:45:06Z |
| publishDate | 2022-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cancer Control |
| spelling | doaj.art-4dcb6373b30d464ba0d35517bed8515b2023-04-27T04:03:29ZengSAGE PublishingCancer Control1526-23592022-12-012910.1177/10732748221144458Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune RetinopathyThomas A. Weppelmann MD, PhD, MPHSabrina Khalil MDNabeel Zafrullah MDSabah Amir MD, MBACurtis E. Margo MD, MPHBackground: Dozens of paraneoplastic syndromes affect the visual system ranging from conjunctival pemphigoid to encephalopathy of the occipital cortex. The most profiled ocular syndromes are bilateral diffuse uveal melanocytic proliferation (BDUMP) and the autoimmune retinopathies. Purpose: To review the critical features of these 2 entities then concentrate on advancements in treatment made within the last 10 years. Study Design: Literature review with structured data abstraction. Results: Major insights into pathogenesis have been wanting. Plasmapheresis appears to improve vision in a substantial proportion of patients with BDUMP. The number of clinical variables that influence visual outcome in paraneoplastic retinopathies combined with the variety of local and systemic treatment options makes interpretation of clinical effectiveness difficult. Conclusions: The rarity of these disorders makes randomized clinical trials unlikely. It may be time for a clinical professional organization to use a modified Delphi method to establish a consensus algorithm for the diagnosis and management of retinal paraneoplastic syndromes to augment clinical communications and clinical trials.https://doi.org/10.1177/10732748221144458 |
| spellingShingle | Thomas A. Weppelmann MD, PhD, MPH Sabrina Khalil MD Nabeel Zafrullah MD Sabah Amir MD, MBA Curtis E. Margo MD, MPH Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy Cancer Control |
| title | Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy |
| title_full | Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy |
| title_fullStr | Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy |
| title_full_unstemmed | Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy |
| title_short | Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy |
| title_sort | ocular paraneoplastic syndromes a critical review of diffuse uveal melanocytic proliferation and autoimmune retinopathy |
| url | https://doi.org/10.1177/10732748221144458 |
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