Resveratrol improves lipid metabolism in diabetic nephropathy rats
Diabetic nephropathy (DN) is a major cause of chronic kidney disease characterized by insulin resistance and lipid deposition in tissues. To this end, we examined the effect of Resveratrol (RES) in streptozotocin (STZ) induced diabetic nephropathy. RES, in a dose dependent manner, decreased the insu...
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| Format: | Article |
| Language: | English |
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IMR Press
2020-06-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/25/10/10.2741/4885 |
| _version_ | 1828796601191104512 |
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| author | Yong-hong Zhao You-Jia Fan |
| author_facet | Yong-hong Zhao You-Jia Fan |
| author_sort | Yong-hong Zhao |
| collection | DOAJ |
| description | Diabetic nephropathy (DN) is a major cause of chronic kidney disease characterized by insulin resistance and lipid deposition in tissues. To this end, we examined the effect of Resveratrol (RES) in streptozotocin (STZ) induced diabetic nephropathy. RES, in a dose dependent manner, decreased the insulin resistance, and improved kidney function and lipid metabolism in STZ treated rats. RES treatment increased p-AMPKα/AMPKα and p-ULK1 S777/ULK1 and the autophagy related proteins (Beclin1, LC3 II/I) and its effects on TC and improvement in insulin resistence were quenched by the inhibitor of autophagy, 3-MA. Together, these results suggest that the effect of RES in treatment of DN may involve AMPKα/mTOR-mediated autophagy. |
| first_indexed | 2024-12-12T04:25:43Z |
| format | Article |
| id | doaj.art-4dcb7361c5134555a3b6c4974296e65a |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-12-12T04:25:43Z |
| publishDate | 2020-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-4dcb7361c5134555a3b6c4974296e65a2022-12-22T00:38:12ZengIMR PressFrontiers in Bioscience-Landmark2768-67012020-06-0125101913192410.2741/4885S2768-6701(20)00159-8Resveratrol improves lipid metabolism in diabetic nephropathy ratsYong-hong Zhao0You-Jia Fan1Department of Pharmacy, Jing’ an District Centre Hospital of Shanghai (Huashan Hospital Fudan University Jing’ An Branch), Shanghaii, 200040, ChinaDepartment of Anesthesiology, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai, 201821, ChinaDiabetic nephropathy (DN) is a major cause of chronic kidney disease characterized by insulin resistance and lipid deposition in tissues. To this end, we examined the effect of Resveratrol (RES) in streptozotocin (STZ) induced diabetic nephropathy. RES, in a dose dependent manner, decreased the insulin resistance, and improved kidney function and lipid metabolism in STZ treated rats. RES treatment increased p-AMPKα/AMPKα and p-ULK1 S777/ULK1 and the autophagy related proteins (Beclin1, LC3 II/I) and its effects on TC and improvement in insulin resistence were quenched by the inhibitor of autophagy, 3-MA. Together, these results suggest that the effect of RES in treatment of DN may involve AMPKα/mTOR-mediated autophagy.https://www.imrpress.com/journal/FBL/25/10/10.2741/4885resveratrollipid metabolisminsulin resistancediabetic nephropathyautophagy |
| spellingShingle | Yong-hong Zhao You-Jia Fan Resveratrol improves lipid metabolism in diabetic nephropathy rats Frontiers in Bioscience-Landmark resveratrol lipid metabolism insulin resistance diabetic nephropathy autophagy |
| title | Resveratrol improves lipid metabolism in diabetic nephropathy rats |
| title_full | Resveratrol improves lipid metabolism in diabetic nephropathy rats |
| title_fullStr | Resveratrol improves lipid metabolism in diabetic nephropathy rats |
| title_full_unstemmed | Resveratrol improves lipid metabolism in diabetic nephropathy rats |
| title_short | Resveratrol improves lipid metabolism in diabetic nephropathy rats |
| title_sort | resveratrol improves lipid metabolism in diabetic nephropathy rats |
| topic | resveratrol lipid metabolism insulin resistance diabetic nephropathy autophagy |
| url | https://www.imrpress.com/journal/FBL/25/10/10.2741/4885 |
| work_keys_str_mv | AT yonghongzhao resveratrolimproveslipidmetabolismindiabeticnephropathyrats AT youjiafan resveratrolimproveslipidmetabolismindiabeticnephropathyrats |