Diagnostics and management techniques in respiratory disorders in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease characterized by relentless increase in weakness of limb and respiratory muscles. Whereas the etiology is still not clear, there have been a remarkable progress in understanding ALS pathogenesis and pathophysiology over the last ye...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Research Center of Neurology
2018-12-01
|
| Series: | Анналы клинической и экспериментальной неврологии |
| Subjects: | |
| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/554/444 |
| _version_ | 1828822537128116224 |
|---|---|
| author | Aleksey V. Vasil’yev Dariya D. Eliseyeva Maria V. Ivanova Ivan A. Kochergin Inessa V. Zakroyshchikova Lev V. Brylev Vasily A. Shtabnitskiy Maria N. Zakharova |
| author_facet | Aleksey V. Vasil’yev Dariya D. Eliseyeva Maria V. Ivanova Ivan A. Kochergin Inessa V. Zakroyshchikova Lev V. Brylev Vasily A. Shtabnitskiy Maria N. Zakharova |
| author_sort | Aleksey V. Vasil’yev |
| collection | DOAJ |
| description | Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease characterized by relentless increase in weakness of limb and respiratory muscles. Whereas the etiology is still not clear, there have been a remarkable progress in understanding ALS pathogenesis and pathophysiology over the last years. In 2017 the second drug that can alter ALS progression rate has been registered. Nevertheless, the prognosis remains very poor and the average life expectancy in ALS does not exceed 5 years. The most common causes of death in ALS are respiratory complications and respiratory failure. Consequently, monitoring of the respiratory system function in ALS patients by neurologists and pulmonologists is crucial for survival and prolongation of life in this condition. Currently the most available diagnostic tool for the assessment of the respiratory profile in ALS is spirometry. Other methods, such as measurement of sniff nasal pressure, overnight oximetry and polysomnography, are also important but, due to technical complexity, their use in routine practice is limited. The principal method of respiratory support used in ALS is noninvasive lung ventilation (NIV). It can increase the average life expectancy and improve the patients quality of life. Invasive lung ventilation with endotracheal tube is another technique that can increase life expectancy and improve quality of life. However, the number of patients accepting this type of mechanical ventilation is very low. Multidisciplinary approach involving different medical specialists including neurologists, pulmonologists and critical care physicians is the key to successive management of ALS patients with respiratory disorders. |
| first_indexed | 2024-12-12T13:15:33Z |
| format | Article |
| id | doaj.art-4dcdd1eb51ac4bb4b77034d8f4c5ae81 |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-12-12T13:15:33Z |
| publishDate | 2018-12-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-4dcdd1eb51ac4bb4b77034d8f4c5ae812022-12-22T00:23:25ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332018-12-01124768510.25692/ACEN.2018.4.11425Diagnostics and management techniques in respiratory disorders in amyotrophic lateral sclerosisAleksey V. Vasil’yev0Dariya D. Eliseyeva1Maria V. Ivanova2Ivan A. Kochergin3Inessa V. Zakroyshchikova4Lev V. Brylev5Vasily A. Shtabnitskiy6Maria N. Zakharova7Research Center of NeurologyResearch Center of NeurologyResearch Сenter of NeurologyResearch Center of NeurologyResearch Center of NeurologyMoscow Сity Сlinical Нospital named after V.M. BuyanovPirogov Russian National Research Medical UniversityResearch Center of NeurologyAmyotrophic lateral sclerosis (ALS) is a rapidly progressive disease characterized by relentless increase in weakness of limb and respiratory muscles. Whereas the etiology is still not clear, there have been a remarkable progress in understanding ALS pathogenesis and pathophysiology over the last years. In 2017 the second drug that can alter ALS progression rate has been registered. Nevertheless, the prognosis remains very poor and the average life expectancy in ALS does not exceed 5 years. The most common causes of death in ALS are respiratory complications and respiratory failure. Consequently, monitoring of the respiratory system function in ALS patients by neurologists and pulmonologists is crucial for survival and prolongation of life in this condition. Currently the most available diagnostic tool for the assessment of the respiratory profile in ALS is spirometry. Other methods, such as measurement of sniff nasal pressure, overnight oximetry and polysomnography, are also important but, due to technical complexity, their use in routine practice is limited. The principal method of respiratory support used in ALS is noninvasive lung ventilation (NIV). It can increase the average life expectancy and improve the patients quality of life. Invasive lung ventilation with endotracheal tube is another technique that can increase life expectancy and improve quality of life. However, the number of patients accepting this type of mechanical ventilation is very low. Multidisciplinary approach involving different medical specialists including neurologists, pulmonologists and critical care physicians is the key to successive management of ALS patients with respiratory disorders.https://annaly-nevrologii.com/journal/pathID/article/viewFile/554/444amyotrophic lateral sclerosisrespiratory disordersnoninvasive ventilationinvasive ventilation |
| spellingShingle | Aleksey V. Vasil’yev Dariya D. Eliseyeva Maria V. Ivanova Ivan A. Kochergin Inessa V. Zakroyshchikova Lev V. Brylev Vasily A. Shtabnitskiy Maria N. Zakharova Diagnostics and management techniques in respiratory disorders in amyotrophic lateral sclerosis Анналы клинической и экспериментальной неврологии amyotrophic lateral sclerosis respiratory disorders noninvasive ventilation invasive ventilation |
| title | Diagnostics and management techniques in respiratory disorders in amyotrophic lateral sclerosis |
| title_full | Diagnostics and management techniques in respiratory disorders in amyotrophic lateral sclerosis |
| title_fullStr | Diagnostics and management techniques in respiratory disorders in amyotrophic lateral sclerosis |
| title_full_unstemmed | Diagnostics and management techniques in respiratory disorders in amyotrophic lateral sclerosis |
| title_short | Diagnostics and management techniques in respiratory disorders in amyotrophic lateral sclerosis |
| title_sort | diagnostics and management techniques in respiratory disorders in amyotrophic lateral sclerosis |
| topic | amyotrophic lateral sclerosis respiratory disorders noninvasive ventilation invasive ventilation |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/554/444 |
| work_keys_str_mv | AT alekseyvvasilyev diagnosticsandmanagementtechniquesinrespiratorydisordersinamyotrophiclateralsclerosis AT dariyadeliseyeva diagnosticsandmanagementtechniquesinrespiratorydisordersinamyotrophiclateralsclerosis AT mariavivanova diagnosticsandmanagementtechniquesinrespiratorydisordersinamyotrophiclateralsclerosis AT ivanakochergin diagnosticsandmanagementtechniquesinrespiratorydisordersinamyotrophiclateralsclerosis AT inessavzakroyshchikova diagnosticsandmanagementtechniquesinrespiratorydisordersinamyotrophiclateralsclerosis AT levvbrylev diagnosticsandmanagementtechniquesinrespiratorydisordersinamyotrophiclateralsclerosis AT vasilyashtabnitskiy diagnosticsandmanagementtechniquesinrespiratorydisordersinamyotrophiclateralsclerosis AT marianzakharova diagnosticsandmanagementtechniquesinrespiratorydisordersinamyotrophiclateralsclerosis |